Optical measures of cerebral arterial function as predictors of brain and cognitive aging

脑动脉功能的光学测量作为大脑和认知衰老的预测因子

• 批准号: 10394936
• 负责人: Monica Fabiani
• 金额: $ 69.2万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394936
• 关键词: 5 year old; Age; Age-Years; Age-associated memory impairment; Alzheimer' s Disease; Aorta; Arteriogram; Arteriosclerosis; Blood Vessels; Blood flow; Body mass index; Brain; Brain region; Cerebral Arteriosclerosis; Cerebral small vessel disease; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrum; Chronic stress; Clinical; Cognitive; Cognitive aging; Data; Dementia; Development; Diastolic blood pressure; Early Diagnosis; Early Intervention; Elasticity; Elderly; Event; Evolution; Female; Framingham Heart Study; Head and neck structure; Health; Hypertension; Image; Impaired cognition; Individual; Intervention; Investigation; Lead; Link; Location; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Modeling; Neurologic; Optics; Outcome; Pathology; Pattern; Peripheral; Physiologic pulse; Play; Prediabetes syndrome; Prevention; Relaxation; Research; Resolution; Risk; Risk Factors; Role; Sampling; Shapes; Signal Transduction; Smoking; Stenosis; Surface; System; Time; Transcranial Doppler Ultrasonography; Ultrasonography; Variant; Vascular Dementia; age related; aging brain; arm; arterial stiffness; base; blood lipid; cardiorespiratory fitness; cerebral atrophy; cerebrovascular; cerebrovascular health; clinical application; cognitive function; design; diffuse optical tomography; economic cost; femoral artery; follow-up; high body mass index; imaging approach; indexing; innovation; lifestyle factors; male; middle age; mild cognitive impairment; normal aging; novel; physical inactivity; prevent; prospective; societal costs; therapy design; tool; white matter

Cerebrovascular health (and in particular arterial stiffening, or arteriosclerosis) is a significant contributor to age-related decline, and exerts a central role in a number of pathologies, including Alzheimer's disease (AD) and vascular dementia. Arteriosclerosis is progressive and considered to be irreversible. Therefore its early detection is of critical importance. As extensively demonstrated by the Framingham Heart Study and other longitudinal research, life style factors, and in particular physical inactivity, play a central role in the development of arteriosclerosis. Cerebral arteriosclerosis is currently assessed either indirectly with peripheral measures or more directly in the neck and head (with carotid or trans- cranial Doppler sonography, TCD), which provide useful clinical information but at just a few measurement points. Our lab has recently developed a new imaging approach, based on the study of the arterial pulse measured with diffuse optical tomography (pulse-DOT), which allows for the mapping of arterial status across the entire cortical mantle, with high reliability and replicability. We have shown that in normally aging older adults, low values of PReFx (pulse relaxation function, a measure of pulse shape indicative of arterial elasticity) are correlated with older age, lower cardiorespiratory fitness (CRF), and overall greater age-related brain atrophy and white matter signal abnormalities (WMSA). Crucially, we have also shown that local/regional variations in arterial stiffness from one brain region to another correlate with volumetric variations in the same regions. These regional effects provide a stronger functional link between arterial health and early structural signs of brain aging than those derived from global measures of arterial elasticity, pointing at the importance of arterial function in the chain of events that may lead, over time, to cognitive and brain volumetric losses. In the proposed research, based on a mixed cross-sectional/longitudinal (30 month) design involving 200 individuals between 50 and 70 years of age, we aim to: (1) Demonstrate that pulse-DOT will relate to cerebrovascular risk cross- sectionally and also prospectively over a 30-month period. Individuals classified by degree of presence of sub-clinical risk factors relating to low CRF are expected to show a graded relationship with the PReFx index of arterial stiffness, as well as with indices of cerebrovascular reactivity (CVR). Decreasing PReFx pulse-DOT values over follow-up are then expected to predict a worsening of risk. (2) Demonstrate that regional changes (over 30 months) in cerebral arterial function are associated with regional changes in brain structural (i.e., indicating signs of brain atrophy and WMSA) and blood flow parameters in the same regions (measured with magnetic resonance imaging, MRI). (3) Identify the relationship between cognitive function, regional vascular stiffening and CVR at baseline and over the follow-up period. We anticipate a concordance of regional deficits in vascular stiffening and vascular reactivity that will relate to specific deficits in cognitive processing. These findings should provide information not only on global effects of variations in cerebral arterial stiffness on brain and cognitive aging trajectories, but also on the regional profiles of arterial stiffness. In the long term this approach may provide a tool for studying cerebrovascular effects in basic and clinical applications, and for guiding individually tailored early interventions, designed to prevent age-related cognitive decline, MCI and AD.

脑血管健康（特别是动脉硬化或动脉硬化）是与年龄相关的一个重要因素

项目成果

A wireless, skin-interfaced biosensor for cerebral hemodynamic monitoring in pediatric care.

• DOI: 10.1073/pnas.2019786117
• 发表时间: 2020-12-15
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Rwei AY;Lu W;Wu C;Human K;Suen E;Franklin D;Fabiani M;Gratton G;Xie Z;Deng Y;Kwak SS;Li L;Gu C;Liu A;Rand CM;Stewart TM;Huang Y;Weese-Mayer DE;Rogers JA
• 通讯作者: Rogers JA

Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.

• DOI: 10.1111/psyp.13796
• 发表时间: 2021-07
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Zimmerman B;Rypma B;Gratton G;Fabiani M
• 通讯作者: Fabiani M

Proof-of-concept evidence for trimodal simultaneous investigation of human brain function.

• DOI: 10.1002/hbm.25541
• 发表时间: 2021-09
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Moore M;Maclin EL;Iordan AD;Katsumi Y;Larsen RJ;Bagshaw AP;Mayhew S;Shafer AT;Sutton BP;Fabiani M;Gratton G;Dolcos F
• 通讯作者: Dolcos F

A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.

• DOI: 10.1016/bs.plm.2022.08.001
• 发表时间: 2022
• 期刊: The psychology of learning and motivation

Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults.

• DOI: 10.1038/s41598-020-76160-9
• 发表时间: 2020-11-24
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Gratton G;Weaver SR;Burley CV;Low KA;Maclin EL;Johns PW;Pham QS;Lucas SJE;Fabiani M;Rendeiro C
• 通讯作者: Rendeiro C