The National Center for Microscopy and Imaging Research, a Community-wide Scientific Resource

项目摘要和摘要 加州大学圣地亚哥分校的国家显微镜和成像研究中心(NCMIR)是一个重要而独特的 NIGMS支持生物医学技术开发研究资源(BTRR)。NCMIR即将完成第31次 以及持续运作的最后一年，因此没有资格根据新的指导方针续期 管理P41计划。有了这项建议，我们要求稳定支持，以帮助缓解过渡 以独立的可持续性为中心，并允许有序地完成资源的现有池 支持生物医学研究项目。NCMIR的使命是促进专门技术的协调使用 分子探针、新的样品制备方法、前沿显微镜和成像技术， 和可扩展的计算工具，帮助调查人员穿越难以导航的空间和时间尺度， 提供对多尺度结构/功能关系的新见解，并提供对 许多健康、疾病和衰老话题背后的大分子机制。在转型过程中 资源到自给自足的社区范围的科学资源，我们提供了我们的运营和 管理资源如何支持正在进行的研究用户、准备开发的维护计划 技术用于广泛传播，并修改其社区参与交流的方法 提供技术、服务和资源。我们还制定了一个“过渡计划”，以调整现有的成本- 恢复进程并建立新的机制，以稳定对资源运作的支持， 我们加州大学旧金山分校内部利益相关者的承诺为我们提供了支持 迭戈和更伟大的拉荷亚·梅萨。最后，我们制定了《评估计划》，对资源进行量化和评估 绩效和对社区的影响，提出短期内部指标，以优化资源 利用率和持续改进，以及长期目标指标，以衡量对 科学界。

PROJECT SUMMARY AND ABSTRACT The National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego is a vital and unique NIGMS supported biomedical technology development research resource (BTRR). NCMIR is completing its 31st and final funded year of continuous operation and is thereby ineligible for renewal under new guidelines governing the P41 program. With this proposal, we request stabilizing support to help ease the transition of the Center to independent sustainability and to allow for the ordered completion of the resource’s existing pool of supported biomedical research projects. NCMIR’s mission is to advance the coordinated use of specialized molecular probes, novel specimen preparation methods, leading-edge microscopy and imaging technologies, and scalable computational tools to help investigators traverse difficult to navigate spatial and temporal scales, deliver new insight into multiscale structure/function relationships, and provide a fundamental understanding of the macromolecular mechanisms underlying many topics in health, disease, and aging. In transitioning the resource to a self-sustaining community-wide scientific resource, we provide details of our ‘Operation and Maintenance Plan’ to govern how the resource supports ongoing research users, prepares developed technologies for broad dissemination, and modifies its approach to community engagement to communicate offered technologies, services, and resources. We further establish a ‘Transition Plan’ to scale existing cost- recovery processes and put into place new mechanisms to stabilize support for the operation of the resource, buttressed by commitments from stakeholders within our home institution at the University of California, San Diego and the greater La Jolla mesa. Last, we establish an ‘Evaluation Plan’ to quantify and assess resource performance and impact on the community, putting forth both Short-term Internal Metrics, to optimize resource utilization and make ongoing improvements, and Long-term Objective Metrics, to gauge overall impact on the scientific community.