Advancing Multi-Color EM via Direct Detector-enabled 4D-STEM
通过支持直接检测器的 4D-STEM 推进多色 EM
基本信息
- 批准号:10795540
- 负责人:
- 金额:$ 22.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAccelerationAdvanced DevelopmentAwardBenchmarkingCellsChemistryColorComplexComputer softwareData SetDetectionDevelopmentDevicesElectron MicroscopyElectronsElementsEnergy-Filtering Transmission Electron MicroscopyEquipmentFeasibility StudiesFundingIndustryLabelMethodologyMethodsMolecularNoiseOutcomeParentsPerformanceRequest for ApplicationsResearch Project GrantsResolutionSignal TransductionSpecific qualifier valueSpecimenSpeedStructureTechnologyTissuesTransmission Electron MicroscopyValidationWorkcomputerized data processingcontrast imagingdetectornew technologynoveltransmission process
项目摘要
PROJECT SUMMARY / ABSTRACT
This competitive supplement application requests funds to procure a high speed direct electron counting detector
for analytical Energy Filtered TEM (EFTEM). This detector will allow us to accelerate the validation and
performance benchmarking of new multi-label, elemental probes under development to scale the impact and
accessibility of multicolor electron microscopy (ColorEM). This work will be conducted in the context of an active
research project that is advancing the development of a novel method for ColorEM, employing new technologies
for ultra-high-speed 4D-STEM (5 R01GM138780-03). This funded project is performing the feasibility studies
and surmounting the technical challenges to: 1) make multi-labelled EM specimens with elemental probe
combinations optimized for ColorSTEM (and extensible to all methods for ColorEM); 2) troubleshoot the first use
of potentially transformative new technologies for STEM detection and associated capabilities for atomic-number
(Z) contrast imaging; and, 3) work out the methodology for processing/analysis of very large primary data sets
so as to accelerate elemental differentiation/signal interpretation and allow for display of ColorSTEM results. The
ultra-fast direct electron detector requested, will allow us to accelerate and sharpen our ability to record,
compare, and optimize the performance elemental probe combinations (for both signal-to-noise and differential
contrast) as well as provide for a more sensitive and accurate validation of the quantitative performance of our
data processing routines, which work hand-in-hand with the labeling chemistry to allow us to reliably and
accurately discern the signal recorded from one selectively labeled structure from the specific signal of another.
The equipment item requested is an Apollo (Direct Electron, LP), low-noise, high-speed electron-counting, direct
detection device (DDD) for transmission electron microscopy, which possesses an industry-leading signal-to-
noise and throughput specification that will allow us to more rapidly and accurately validate the performance of
new elemental probes, thus accelerating the completion of Aims 1 and 3 of the parent award.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mark H Ellisman其他文献
Mark H Ellisman的其他文献
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{{ truncateString('Mark H Ellisman', 18)}}的其他基金
200keV, Energy Filtered, Intermediate-High Voltage Transmission Electron Microscope(IVEM)"
200keV、能量过滤、中高压透射电子显微镜(IVEM)"
- 批准号:
10642585 - 财政年份:2023
- 资助金额:
$ 22.4万 - 项目类别:
Scalable electron tomography for connectomics
用于连接组学的可扩展电子断层扫描
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10410742 - 财政年份:2022
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$ 22.4万 - 项目类别:
Reversing Microglial Inflammarafts and Mitochondrial Dysfunction in Alzheimer's Disease
逆转阿尔茨海默病中的小胶质细胞炎症和线粒体功能障碍
- 批准号:
10607455 - 财政年份:2022
- 资助金额:
$ 22.4万 - 项目类别:
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource
国家显微镜和成像研究中心:大脑技术集成和传播资源
- 批准号:
10334513 - 财政年份:2021
- 资助金额:
$ 22.4万 - 项目类别:
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource
国家显微镜和成像研究中心:大脑技术集成和传播资源
- 批准号:
10544010 - 财政年份:2021
- 资助金额:
$ 22.4万 - 项目类别:
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource
国家显微镜和成像研究中心:大脑技术集成和传播资源
- 批准号:
10116087 - 财政年份:2021
- 资助金额:
$ 22.4万 - 项目类别:
The National Center for Microscopy and Imaging Research, a Community-wide Scientific Resource
国家显微镜和成像研究中心,社区范围的科学资源
- 批准号:
10399337 - 财政年份:2020
- 资助金额:
$ 22.4万 - 项目类别:
Advancing Multi-Color EM via Direct Detector-enabled 4D-STEM
通过支持直接检测器的 4D-STEM 推进多色 EM
- 批准号:
10031737 - 财政年份:2020
- 资助金额:
$ 22.4万 - 项目类别:
The National Center for Microscopy and Imaging Research, a Community-wide Scientific Resource
国家显微镜和成像研究中心,社区范围的科学资源
- 批准号:
10212509 - 财政年份:2020
- 资助金额:
$ 22.4万 - 项目类别:
The National Center for Microscopy and Imaging Research, a Community-wide Scientific Resource
国家显微镜和成像研究中心,社区范围的科学资源
- 批准号:
10400847 - 财政年份:2020
- 资助金额:
$ 22.4万 - 项目类别:
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