Soft Silicone Electrode Nets: implantable technology for visceral organ neural interfacing and functional evaluation

软硅胶电极网:用于内脏器官神经接口和功能评估的植入技术

基本信息

  • 批准号:
    10402064
  • 负责人:
  • 金额:
    $ 6.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-15 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

Abstract Visceral organs present unique challenges to studying functional physiology and neural control. Visceral organs are often surrounded by a nerve plexus that provides distributed innervation along the organ surface and contain autonomic ganglia that can modulate function locally. Given this complexity, creating functional maps of visceral organ innervation is challenging. Another challenge is measuring organ state itself. This is significantly exacerbated by the fact that many of these organs are soft, elastic, and undergo large volume changes. In this proposal, we will develop soft silicone electrode nets compatible with these unique challenges and that can envelop visceral organs and deploy high-resolution electrodes to arbitrary positions on the organ surface. This approach is based on a 3D printed silicone electrode technology. These electrode nets will be augmented with strain gauge sensors and electrical impedance tomography electrodes to monitor physiological organ state. Ultimately, this new class of devices will 1) be intrinsically soft and elastic to allow conformation with visceral organs that undergo large volume changes, 2) integrate organ state sensors based on strain gauges and electrical impedance tomography, 3) prevent delamination issues typically associated with other thin film electrode manufacturing processes, and 4) allow rapid customization to cost-effectively transition to any organ system in animals or humans. This technology is based on materials that have a history of use in biomedical implants and are therefore potentially suitable for conducting neural mapping and electrophysiological studies of human organs in vivo. We will evaluate device performance using the bladder and urethra as a model due to the challenging interface requirements (e.g. large volume changes) and potential clinical relevance. Overactive bladder and urinary incontinence affects millions of people worldwide, is associated with costs upwards of $60 billion each year in the United States, and leads to significant decreases in quality of life. Electrode nets will be tested in acute cat experiments where we will determine the electrode-tissue mechanical stability, evaluate embedded sensor performance, and develop functional neural maps of the surface of the bladder and urethra. We will also validate device performance in a series of chronic animal experiments where device performance will be monitored for up to four months post-implant. An important feature of this enabling technology and associated manufacturing process is that these devices will be able to be quickly and cost-effectively redesigned to study other visceral organ systems including the stomach, intestines, and colon across a range of animal models as well as humans.
摘要 内脏器官对研究功能生理学和神经控制提出了独特的挑战。内脏器官 通常被神经丛包围,该神经丛沿着器官表面提供分布的神经支配, 自主神经节可以局部调节功能。鉴于这种复杂性,创建内脏功能图 器官神经支配是一个挑战另一个挑战是测量器官状态本身。这明显 由于这些器官中的许多是柔软的、有弹性的并且经历大的体积变化的事实而加剧。 在本提案中,我们将开发与这些独特挑战兼容的软硅胶电极网, 可以包裹内脏器官,并将高分辨率电极部署到器官表面的任意位置。 这种方法基于3D打印的硅胶电极技术。这些电极网将被扩大 利用应变仪传感器和电阻抗断层扫描电极来监测生理器官状态。 最终,这类新的装置将1)本质上是柔软和弹性的,以允许与内脏的顺应性。 经历大体积变化的器官,2)集成基于应变仪的器官状态传感器, 电阻抗断层成像,3)防止通常与其它薄膜相关的分层问题 电极制造过程,以及4)允许快速定制,以成本有效地过渡到任何器官 动物或人类的系统。这项技术是基于在生物医学领域有使用历史的材料。 植入物,因此可能适用于进行神经映射和电生理学研究, 人体内器官 由于接口具有挑战性,我们将使用膀胱和尿道作为模型来评价器械性能 要求(例如,大体积变化)和潜在临床相关性。膀胱过度活动症和尿路 尿失禁影响着全世界数百万人,每年与超过600亿美元的成本相关, 美国,并导致生活质量显着下降。将在急性猫中测试电极网 我们将确定电极-组织机械稳定性,评估嵌入式传感器 性能,并开发膀胱和尿道表面的功能神经地图。我们还将验证 在一系列慢性动物实验中,器械性能将被监测, 植入后4个月内。这种使能技术和相关制造的一个重要特征是 这一过程的关键是,这些设备将能够快速、经济地重新设计,以研究其他内脏器官。 器官系统,包括胃、肠和结肠,在一系列动物模型以及人类中。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Robert A Gaunt其他文献

Robert A Gaunt的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Robert A Gaunt', 18)}}的其他基金

Simulations of spinal cord recruitment to optimize bioelectronic interventions for lower urinary tract control
模拟脊髓募集以优化下尿路控制的生物电子干预措施
  • 批准号:
    10207979
  • 财政年份:
    2020
  • 资助金额:
    $ 6.56万
  • 项目类别:
Simulations of spinal cord recruitment to optimize bioelectronic interventions for lower urinary tract control
模拟脊髓募集以优化下尿路控制的生物电子干预措施
  • 批准号:
    10469840
  • 财政年份:
    2020
  • 资助金额:
    $ 6.56万
  • 项目类别:
Coordinated Microstimulation of Sacral Afferent Pathways to Control Continence and Micturition Reflexes
协调骶神经传入通路的微刺激来控制失禁和排尿反射
  • 批准号:
    9903468
  • 财政年份:
    2017
  • 资助金额:
    $ 6.56万
  • 项目类别:
Soft Silicone Electrode Nets: implantable technology for visceral organ neural interfacing and functional evaluation
软硅胶电极网:用于内脏器官神经接口和功能评估的植入技术
  • 批准号:
    10246110
  • 财政年份:
    2017
  • 资助金额:
    $ 6.56万
  • 项目类别:
Soft Silicone Electrode Nets: implantable technology for visceral organ neural interfacing and functional evaluation
软硅胶电极网:用于内脏器官神经接口和功能评估的植入技术
  • 批准号:
    9513136
  • 财政年份:
    2017
  • 资助金额:
    $ 6.56万
  • 项目类别:
Coordinated Microstimulation of Sacral Afferent Pathways to Control Continence and Micturition Reflexes
协调骶神经传入通路的微刺激来控制失禁和排尿反射
  • 批准号:
    9309546
  • 财政年份:
    2017
  • 资助金额:
    $ 6.56万
  • 项目类别:
Soft Silicone Electrode Nets: implantable technology for visceral organ neural interfacing and functional evaluation
软硅胶电极网:用于内脏器官神经接口和功能评估的植入技术
  • 批准号:
    10003455
  • 财政年份:
    2017
  • 资助金额:
    $ 6.56万
  • 项目类别:

相似海外基金

Launching Recycled Flame Retardant Silicone Rubber Manufactured Products into the Aerospace Sector
将再生阻燃硅橡胶制品引入航空航天领域
  • 批准号:
    10076170
  • 财政年份:
    2023
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Grant for R&D
Long-term and Mediated NO-Release Silicone Polymers for Blood Interface Devices
用于血液接口装置的长期介导不释放有机硅聚合物
  • 批准号:
    10654071
  • 财政年份:
    2023
  • 资助金额:
    $ 6.56万
  • 项目类别:
Studieis on the structure formation of asymmetric porous silicone membrane used for recovery of organic solvent from waste liquid
用于废液有机溶剂回收的不对称多孔有机硅膜的结构形成研究
  • 批准号:
    22K05285
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of Smart Silicone Rubber Insulating Materials for HVDC Transmission Systems
高压直流输电系统智能硅橡胶绝缘材料的开发
  • 批准号:
    RGPIN-2018-04409
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Discovery Grants Program - Individual
Monitoring the effects of temperature, electrical and chemical stress on silicone polymers
监测温度、电应力和化学应力对有机硅聚合物的影响
  • 批准号:
    571104-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Alliance Grants
Depolymerization of Silicone to cyclic origo-siloxane by metal complex catalysts
金属配合物催化剂将有机硅解聚为环状硅氧烷
  • 批准号:
    22K19050
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Two-component Robotic Extrusion Additive Manufacturing of Concrete Structures: Silicone-solution Phases and Fiber Distributions for Functionally Graded Materials
混凝土结构的双组分机器人挤压增材制造:功能梯度材料的有机硅溶液相和纤维分布
  • 批准号:
    2217985
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Standard Grant
Revitalizing Used Automotive Rubber: Silicone Rubber Composites
废旧汽车橡胶的复兴:硅橡胶复合材料
  • 批准号:
    570987-2022
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Idea to Innovation
3D Printed Biomaterial with Amino Acid Based Zwitterionic Silicone Coating via ß-Hydroxyalkyl Esters Accelerated Aza-Michael Reaction
通过 α-羟烷基酯加速 Aza-Michael 反应,具有基于氨基酸的两性离子有机硅涂层的 3D 打印生物材料
  • 批准号:
    568999-2022
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Nanoporous silicone monoliths for anisotropic spectroscopic optical scattering media
用于各向异性光谱光学散射介质的纳米多孔有机硅整体料
  • 批准号:
    22K04969
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了