Upright, Low-dose, High-resolution, 3D Breast CT

立式、低剂量、高分辨率、3D 乳腺 CT

• 批准号: 10407991
• 负责人: SRINIVASAN VEDANTHAM
• 金额: $ 70.42万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407991
• 关键词: 3-Dimensional; Address; Anatomy; Arizona; Benchmarking; Benign; Biomedical Engineering; Breast; Breast Cancer Detection; Breast Microcalcification; Breast-Conserving Surgery; Categories; Chest wall structure; Clinical; Clinical Trials; Data; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Sensitivity; Digital Breast Tomosynthesis; Digital Mammography; Discrimination; Disease; Dose; Early Diagnosis; Eligibility Determination; Emerging Technologies; Enhancing Lesion; Evaluation; Feasibility Studies; Future; Generations; Geometry; Goals; Image; Information Systems; Lesion; Low Dose Radiation; Malignant - descriptor; Mammography; Measurement; Modality; Modeling; Monitor; Multimodal Imaging; Neoadjuvant Therapy; Noise; Operative Surgical Procedures; Patients; Performance; Phase; Physics; Population; Positioning Attribute; Radiation Dose Unit; Radiology Specialty; Reader; Receiver Operating Characteristics; Reporting; Research; Research Project Grants; Resolution; Risk; Roentgen Rays; Sampling; Scanning; Screening procedure; Shapes; State-of-the-Art Reviews; Subgroup; System; Techniques; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Tissues; Translating; Translational Research; Universities; Validation; Visualization; Woman; X-Ray Computed Tomography; X-Ray Medical Imaging; base; breast cancer diagnosis; breast density; breast imaging; calcification; cancer imaging; chemotherapy; clinical decision-making; clinical practice; clinical translation; cohort; design; diagnosis evaluation; diagnostic accuracy; imaging detector; imaging system; improved; innovation; malignant breast neoplasm; next generation; predicting response; prospective; prototype; quantitative imaging; quantum; reconstruction; recruit; response; screening; simulation; study characteristics; tomography; tool; treatment planning; tumor

ABSTRACT Dedicated breast CT can eliminate tissue superposition that contributes to false-positives and false- negatives, and alleviates the need for physical compression of the breast. It provides for 3D images at near-isotropic spatial resolution that allows for viewing the breast in any orientation without the need for repeat acquisitions. It is an emerging technology, with only about five teams conducting research, worldwide. In order to develop, evaluate, accelerate its clinical translation, and to facilitate the widespread clinical adaptation of this technology, we are collaborating with GE Global Research to develop an upright patient positioning geometry with advanced technological capabilities designed to eventually allow for breast cancer screening, in addition to diagnostic imaging. The technological advanced proposed include an x-ray imaging detector with reduced system (electronic) noise, data readout rates improved by a factor of at least 2, and improved spatial sampling (pixel pitch) by a factor of 2 or more; a short-scan acquisition trajectory with angular range not exceeding 270-degrees that will improve patient positioning; and, the use of model-based iterative reconstruction techniques. All these technological advances are focused on improving posterior coverage, reducing the radiation dose to the breast so that it is similar to a standard 2- view mammography exam, and improving the visualization of microcalcifications; all with an aim of making it suitable for breast cancer screening in the future. Importantly, the upright geometry allows for rapid clinical adaptation as it allows for easy replacement of mammography and digital breast tomosynthesis systems, even in small mammography rooms, and addresses the patient discomfort observed with the prone breast CT. The research is broadly organized in two phases. In the first phase, all design factors and operational parameters will be verified through physics-based numerical simulations and empirical studies using the bench-top prototype system. In the second phase, we will conduct a clinical feasibility study that will recruit subjects from two cohorts: BIRADS 4/5, and screening population, to determine if the advanced technological approach using the upright, low-dose, high-resolution dedicated breast CT system improves the diagnostic accuracy compared to digital breast tomosynthesis. To our knowledge, this will be first study to directly compare digital breast tomosynthesis with dedicated breast CT. Thus, the proposed research will develop an innovative design concept for unprecedented impact in breast cancer imaging that will enable breast imaging without physical compression and at radiation dose similar to mammography. To our knowledge a compression-free breast CT system incorporating the aforementioned features does not exist.

摘要