Upright, Low-dose, High-resolution, 3D Breast CT

立式、低剂量、高分辨率、3D 乳腺 CT

• 批准号: 10407991
• 负责人: SRINIVASAN VEDANTHAM
• 金额: $ 70.42万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407991
• 关键词: 3-Dimensional; Address; Anatomy; Arizona; Benchmarking; Benign; Biomedical Engineering; Breast; Breast Cancer Detection; Breast Microcalcification; Breast-Conserving Surgery; Categories; Chest wall structure; Clinical; Clinical Trials; Data; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Sensitivity; Digital Breast Tomosynthesis; Digital Mammography; Discrimination; Disease; Dose; Early Diagnosis; Eligibility Determination; Emerging Technologies; Enhancing Lesion; Evaluation; Feasibility Studies; Future; Generations; Geometry; Goals; Image; Information Systems; Lesion; Low Dose Radiation; Malignant - descriptor; Mammography; Measurement; Modality; Modeling; Monitor; Multimodal Imaging; Neoadjuvant Therapy; Noise; Operative Surgical Procedures; Patients; Performance; Phase; Physics; Population; Positioning Attribute; Radiation Dose Unit; Radiology Specialty; Reader; Receiver Operating Characteristics; Reporting; Research; Research Project Grants; Resolution; Risk; Roentgen Rays; Sampling; Scanning; Screening procedure; Shapes; State-of-the-Art Reviews; Subgroup; System; Techniques; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Tissues; Translating; Translational Research; Universities; Validation; Visualization; Woman; X-Ray Computed Tomography; X-Ray Medical Imaging; base; breast cancer diagnosis; breast density; breast imaging; calcification; cancer imaging; chemotherapy; clinical decision-making; clinical practice; clinical translation; cohort; design; diagnosis evaluation; diagnostic accuracy; imaging detector; imaging system; improved; innovation; malignant breast neoplasm; next generation; predicting response; prospective; prototype; quantitative imaging; quantum; reconstruction; recruit; response; screening; simulation; study characteristics; tomography; tool; treatment planning; tumor

ABSTRACT Dedicated breast CT can eliminate tissue superposition that contributes to false-positives and false- negatives, and alleviates the need for physical compression of the breast. It provides for 3D images at near-isotropic spatial resolution that allows for viewing the breast in any orientation without the need for repeat acquisitions. It is an emerging technology, with only about five teams conducting research, worldwide. In order to develop, evaluate, accelerate its clinical translation, and to facilitate the widespread clinical adaptation of this technology, we are collaborating with GE Global Research to develop an upright patient positioning geometry with advanced technological capabilities designed to eventually allow for breast cancer screening, in addition to diagnostic imaging. The technological advanced proposed include an x-ray imaging detector with reduced system (electronic) noise, data readout rates improved by a factor of at least 2, and improved spatial sampling (pixel pitch) by a factor of 2 or more; a short-scan acquisition trajectory with angular range not exceeding 270-degrees that will improve patient positioning; and, the use of model-based iterative reconstruction techniques. All these technological advances are focused on improving posterior coverage, reducing the radiation dose to the breast so that it is similar to a standard 2- view mammography exam, and improving the visualization of microcalcifications; all with an aim of making it suitable for breast cancer screening in the future. Importantly, the upright geometry allows for rapid clinical adaptation as it allows for easy replacement of mammography and digital breast tomosynthesis systems, even in small mammography rooms, and addresses the patient discomfort observed with the prone breast CT. The research is broadly organized in two phases. In the first phase, all design factors and operational parameters will be verified through physics-based numerical simulations and empirical studies using the bench-top prototype system. In the second phase, we will conduct a clinical feasibility study that will recruit subjects from two cohorts: BIRADS 4/5, and screening population, to determine if the advanced technological approach using the upright, low-dose, high-resolution dedicated breast CT system improves the diagnostic accuracy compared to digital breast tomosynthesis. To our knowledge, this will be first study to directly compare digital breast tomosynthesis with dedicated breast CT. Thus, the proposed research will develop an innovative design concept for unprecedented impact in breast cancer imaging that will enable breast imaging without physical compression and at radiation dose similar to mammography. To our knowledge a compression-free breast CT system incorporating the aforementioned features does not exist.

摘要 专用的乳腺CT可以消除导致假阳性和假阳性的组织重叠。 负作用，并减轻对乳房的物理压迫的需要。它在以下位置提供3D图像 近乎各向同性的空间分辨率，允许以任何方向查看乳房，而不需要 重复收购。这是一项新兴技术，只有大约五个团队进行研究， 全世界。为了开发、评估、加速其临床移植，促进其广泛应用 临床适应这项技术，我们正在与GE Global Research合作开发一种直立式 患者定位几何体具有先进的技术功能，旨在最终实现 除了诊断成像，还有乳腺癌筛查。建议的技术进步包括 一种具有降低的系统(电子)噪声的X射线成像探测器，数据读出速率提高了1倍 至少2，并将空间采样(像素间距)提高2倍或更多；短扫描采集 角度范围不超过270度的轨迹将改善患者的定位；以及使用 基于模型的迭代重建技术。所有这些技术进步都集中在 改善后方覆盖，减少对乳房的辐射剂量，使其类似于标准的2- 查看乳房X光检查，改善微钙化的可视化；所有这些都是为了实现这一目标 适用于未来的乳腺癌筛查。重要的是，直立的几何形状允许快速临床 适应，因为它允许容易地替换乳房X光照相和数字乳房断层合成系统， 甚至在小的乳房X光照相室，并解决了患者观察到的俯卧乳房不适 CT.这项研究大致分为两个阶段。在第一阶段，所有设计因素和运营 参数将通过基于物理的数值模拟和经验研究进行验证，使用 台式原型系统。在第二阶段，我们将进行临床可行性研究，将招募 来自两个队列的受试者：BIRADS 4/5和筛查人群，以确定晚期 使用直立、低剂量、高分辨率专用乳腺CT系统的技术方法得到改进 与数字乳房断层成像相比，诊断准确率更高。据我们所知，这将是第一次研究 目的：直接比较数字化乳腺断层扫描和专用乳腺CT。因此，拟议的研究将 开发创新的设计概念，在乳腺癌成像领域产生前所未有的影响，从而实现 无需物理压缩且辐射剂量与乳房X光照相类似的乳房成像。致我们的 知识不存在包含上述特征的无压缩乳腺CT系统。