Upright, Low-dose, High-resolution, 3D Breast CT
立式、低剂量、高分辨率、3D 乳腺 CT
基本信息
- 批准号:10627825
- 负责人:
- 金额:$ 62.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAccelerationAddressAdjuvant ChemotherapyArizonaBenchmarkingBenignBiomedical EngineeringBreastBreast Cancer DetectionBreast MicrocalcificationBreast-Conserving SurgeryCategoriesChest wall structureClinicalClinical TrialsCollaborationsDataDedicationsDevelopmentDiagnosisDiagnosticDiagnostic ImagingDiagnostic SensitivityDigital Breast TomosynthesisDigital MammographyDiscriminationDiseaseDoseEarly DiagnosisElectronicsEligibility DeterminationEmerging TechnologiesEnhancing LesionEvaluationFeasibility StudiesFutureGenerationsGeometryGoalsImageInformation SystemsLesionLow Dose RadiationMalignant - descriptorMammographyMeasurementModalityModelingMonitorMultimodal ImagingNeoadjuvant TherapyNoiseOperative Surgical ProceduresPatientsPerformancePhasePhysicsPopulationPositioning AttributePublicationsRadiation Dose UnitRadiology SpecialtyReaderReceiver Operating CharacteristicsRegional AnatomyReportingResearchResearch Project GrantsResolutionRisk EstimateRoentgen RaysSamplingScanningScreening procedureShapesState-of-the-Art ReviewsSubgroupSystemTechniquesTechnologyThree-Dimensional ImagingTissuesTranslatingTranslational ResearchUniversitiesValidationVisualizationWomanX-Ray Computed TomographyX-Ray Medical Imagingbreast cancer diagnosisbreast densitybreast imagingcalcificationcancer imagingclinical decision-makingclinical practiceclinical translationcohortdesigndiagnosis evaluationdiagnostic accuracyhigh dimensionalityimaging detectorimaging systemimprovedinnovationmalignant breast neoplasmnext generationpredicting responseprospectiveprototypequantitative imagingquantumreconstructionrecruitresponsescreeningsimulationstudy characteristicstomographytooltreatment planningtreatment responsetumor
项目摘要
ABSTRACT
Dedicated breast CT can eliminate tissue superposition that contributes to false-positives and false-
negatives, and alleviates the need for physical compression of the breast. It provides for 3D images at
near-isotropic spatial resolution that allows for viewing the breast in any orientation without the need for
repeat acquisitions. It is an emerging technology, with only about five teams conducting research,
worldwide. In order to develop, evaluate, accelerate its clinical translation, and to facilitate the widespread
clinical adaptation of this technology, we are collaborating with GE Global Research to develop an upright
patient positioning geometry with advanced technological capabilities designed to eventually allow for
breast cancer screening, in addition to diagnostic imaging. The technological advanced proposed include
an x-ray imaging detector with reduced system (electronic) noise, data readout rates improved by a factor of
at least 2, and improved spatial sampling (pixel pitch) by a factor of 2 or more; a short-scan acquisition
trajectory with angular range not exceeding 270-degrees that will improve patient positioning; and, the use
of model-based iterative reconstruction techniques. All these technological advances are focused on
improving posterior coverage, reducing the radiation dose to the breast so that it is similar to a standard 2-
view mammography exam, and improving the visualization of microcalcifications; all with an aim of making it
suitable for breast cancer screening in the future. Importantly, the upright geometry allows for rapid clinical
adaptation as it allows for easy replacement of mammography and digital breast tomosynthesis systems,
even in small mammography rooms, and addresses the patient discomfort observed with the prone breast
CT. The research is broadly organized in two phases. In the first phase, all design factors and operational
parameters will be verified through physics-based numerical simulations and empirical studies using the
bench-top prototype system. In the second phase, we will conduct a clinical feasibility study that will recruit
subjects from two cohorts: BIRADS 4/5, and screening population, to determine if the advanced
technological approach using the upright, low-dose, high-resolution dedicated breast CT system improves
the diagnostic accuracy compared to digital breast tomosynthesis. To our knowledge, this will be first study
to directly compare digital breast tomosynthesis with dedicated breast CT. Thus, the proposed research will
develop an innovative design concept for unprecedented impact in breast cancer imaging that will enable
breast imaging without physical compression and at radiation dose similar to mammography. To our
knowledge a compression-free breast CT system incorporating the aforementioned features does not exist.
摘要
专用乳腺CT可以消除导致假阳性和假阳性的组织重叠,
消极的,并强调了对乳房的物理压迫的需要。它提供3D图像,
近各向同性的空间分辨率,允许在任何方向上观察乳房,
重复收购。这是一项新兴技术,只有大约五个团队进行研究,
国际吧为了开发,评估,加速其临床翻译,并促进其广泛传播,
为了适应这项技术的临床应用,我们正在与GE全球研究院合作,
具有先进技术能力的患者定位几何结构,
乳腺癌筛查,除了诊断成像。提出的技术进步包括
X射线成像探测器具有降低的系统(电子)噪声,数据读出速率提高了一个因子,
至少为2,空间采样(像素间距)改进为2倍或更多;短扫描采集
角度范围不超过270度的轨迹,将改善患者定位;以及,使用
基于模型的迭代重建技术。所有这些技术进步都集中在
改善后部覆盖,减少对乳房的辐射剂量,使其类似于标准的2-
查看乳房X光检查,并改善微钙化的可视化;所有这些都旨在使其
适合将来进行乳腺癌筛查。重要的是,直立的几何形状允许快速的临床应用。
适应性,因为它允许轻松更换乳房X射线摄影和数字乳腺断层合成系统,
即使在小的乳房X线照相室中也是如此,并且解决了患者在俯卧乳房时观察到的不适
CT.研究大致分为两个阶段。在第一阶段,所有设计因素和操作
参数将通过基于物理的数值模拟和经验研究进行验证,
台式原型系统。在第二阶段,我们将进行临床可行性研究,
来自两个队列的受试者:BIRADS 4/5和筛选人群,以确定晚期
使用直立式、低剂量、高分辨率专用乳腺CT系统的技术方法提高了
与数字乳腺断层合成摄影相比的诊断准确性。据我们所知,这将是第一次研究
直接比较数字乳腺断层合成摄影与专用乳腺CT。因此,拟议的研究将
开发一种创新的设计理念,对乳腺癌成像产生前所未有的影响,
乳房成像,无物理压迫,辐射剂量与乳房X线摄影相似。对我们
根据现有知识,不存在包含上述特征的无压缩乳房CT系统。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Optical conductivity of triple point fermions.
- DOI:10.1088/1361-648x/abd739
- 发表时间:2021-01-12
- 期刊:
- 影响因子:0
- 作者:Habibi A;Farajollahpour T;Jafari SA
- 通讯作者:Jafari SA
Cone-beam breast CT using an offset detector: effect of detector offset and image reconstruction algorithm.
- DOI:10.1088/1361-6560/ac5fe1
- 发表时间:2022-04-07
- 期刊:
- 影响因子:3.5
- 作者:Tseng, Hsin Wu;Karellas, Andrew;Vedantham, Srinivasan
- 通讯作者:Vedantham, Srinivasan
An attenuation field network for dedicated cone beam breast CT with short scan and offset detector geometry.
- DOI:10.1038/s41598-023-51077-1
- 发表时间:2024-01-03
- 期刊:
- 影响因子:4.6
- 作者:
- 通讯作者:
Breast dosimetry in alternative X-ray-based imaging modalities used in current clinical practices.
当前临床实践中使用的基于 X 射线的替代成像模式的乳房剂量测定。
- DOI:10.1016/j.ejrad.2022.110509
- 发表时间:2022-10
- 期刊:
- 影响因子:3.3
- 作者:Di Maria, S.;Vedantham, S.;Vaz, P.
- 通讯作者:Vaz, P.
Breast Cancer Screening: Opportunities and Challenges with Fully 3D Tomographic X-Ray Imaging.
乳腺癌筛查:全 3D 断层 X 射线成像的机遇和挑战。
- DOI:
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Vedantham,Srinivasan;Karellas,Andrew
- 通讯作者:Karellas,Andrew
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SRINIVASAN VEDANTHAM其他文献
SRINIVASAN VEDANTHAM的其他文献
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{{ truncateString('SRINIVASAN VEDANTHAM', 18)}}的其他基金
Upright, Low-dose, High-resolution, 3D Breast CT
立式、低剂量、高分辨率、3D 乳腺 CT
- 批准号:
10407991 - 财政年份:2019
- 资助金额:
$ 62.99万 - 项目类别:
Reducing mastectomy rates in invasive lobular carcinoma by high-resolution 3D breast CT
通过高分辨率 3D 乳腺 CT 降低浸润性小叶癌的乳房切除率
- 批准号:
9455075 - 财政年份:2017
- 资助金额:
$ 62.99万 - 项目类别:
Reducing mastectomy rates in invasive lobular carcinoma by high-resolution 3D breast CT
通过高分辨率 3D 乳腺 CT 降低浸润性小叶癌的乳房切除率
- 批准号:
8882960 - 财政年份:2015
- 资助金额:
$ 62.99万 - 项目类别:
Quantitative breast cancer risk index from routine 3-D imaging
常规 3D 成像定量乳腺癌风险指数
- 批准号:
8697025 - 财政年份:2013
- 资助金额:
$ 62.99万 - 项目类别:
Quantitative breast cancer risk index from routine 3-D imaging
常规 3D 成像定量乳腺癌风险指数
- 批准号:
8489847 - 财政年份:2013
- 资助金额:
$ 62.99万 - 项目类别:
Design and Optimization of Dedicated Computed Tomography of the Breast
乳腺专用计算机断层扫描的设计与优化
- 批准号:
8073116 - 财政年份:2009
- 资助金额:
$ 62.99万 - 项目类别:
Design and Optimization of Dedicated Computed Tomography of the Breast
乳腺专用计算机断层扫描的设计与优化
- 批准号:
7731139 - 财政年份:2009
- 资助金额:
$ 62.99万 - 项目类别:
Design and Optimization of Dedicated Computed Tomography of the Breast
乳腺专用计算机断层扫描的设计与优化
- 批准号:
7907802 - 财政年份:2009
- 资助金额:
$ 62.99万 - 项目类别:
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