Cancer Biology Training Program

项目摘要 我们要求为我们的T32再提供五年的资金，以支持基础广泛的、跨部门的前期和后期工作。 在圣安东尼奥的德克萨斯大学健康科学中心接受癌症生物学博士后培训 （UTHSA），一个指定的西班牙裔服务机构。在下一个供资期（第11-15年），我们要求3 博士生预科班和3个博士后班。我们的癌症生物学培训计划是唯一的NCI资助的T32在 UTHSA。我们提供密集和严格的培训，在癌症研究和发现的指导下， 经验丰富的导师和专业发展的机会，高度积极的研究生， 博士后研究员，特别是那些来自生物医学研究中代表性不足（UR）的群体。 自2011年8月首次授予T32以来，所有实习生职位（每个职位1名博士后和3名博士后） 奖学金年度）已满员，受训人员的工作效率很高。迄今为止，7名博士生和15名 博士后被任命为T32学员，其中41%（2名前博士和7名博士后）是URs。的 培训方案将继续由同一名主任和联合主任指导，并由一名新的联合主任加强。 董事，并由经验丰富的执行委员会监督。培训师资力量多样，有19名全 9个系的教授、5名副教授和7名助理教授担任共同导师。所有 培训教师在研究生院和我们的NCI指定的梅斯癌症中心享有完全的教师特权 （MCC）。我们的培训教师与众多合作出版物高度互动，拥有强大的资金支持， 研究投资组合（当年每位导师的平均直接成本> 87万美元），经验丰富， 成功地指导博士前和博士后学员。许多新的培训方案具体活动 利用不断增长的基础，转化和临床癌症研究机会（特别是在MCC）， 生物信息学、药物开发和尖端共享资源。年度务虚会和双月会 学员午餐会将让学员展示他们的研究进展，并与该计划互动 联合主任、培训教师、外部咨询委员会和其他受训人员，包括那些 完成训练。该课程还包括科学交流培训和一个坚实的基础， 负责任的研究行为以及严谨性和可重复性。学员将根据其 学术成就及对癌症研究的贡献，任期两年。有 对该培训计划的实质性机构承诺，例如为计划主任提供工资支持，以及 与MCC对第四名博士前实习生的支持相匹配。我们的癌症生物学培训计划寻求 这一延续将继续为下一代独立调查人员的多样性做出贡献 努力实现NCI的目标，改善癌症预防，检测，诊断，治疗， 生存。

Project Summary We request a further five years of funding for our T32 to support broad-based, interdepartmental pre- and postdoctoral training in cancer biology at the University of Texas Health Science Center at San Antonio (UTHSA), a designated Hispanic-Serving Institution. In this next funding period (years 11-15), we request 3 predoctoral slots and 3 postdoctoral slots. Our Cancer Biology Training Program is the only NCI-funded T32 at UTHSA. We provide intensive and rigorous training in cancer research and discovery under the tutelage of seasoned preceptors and professional development opportunities to highly motivated graduate students and postdoctoral research fellows, especially those from groups underrepresented (UR) in biomedical research. Since this T32 was first awarded in August 2011, all trainee positions (1 predoctoral and 3 postdoctoral in each award year) have been filled, and trainees have been highly productive. To date, 7 predoctoral students and 15 postdoctoral fellows have been appointed as T32 trainees, and 41% (2 predocs and 7 postdocs) are URs. The Training Program will continue to be directed by the same Director and Co-Director, enhanced by a new Co- Director, and overseen by a seasoned Executive Committee. The training faculty is diverse, with 19 full professors and 5 associate professors, and 7 assistant professors as Co-Mentors, from 9 departments. All training faculty have full faculty privileges in the Graduate School and our NCI-designated Mays Cancer Center (MCC). Our training faculty are highly interactive with numerous collaborative publications, have strong funded research portfolios (average direct costs >$870K per mentor in the current year), and are experienced and successful in mentoring predoctoral and postdoctoral trainees. Many new Training Program-specific activities leverage growing basic, translational and clinical cancer research opportunities (especially at the MCC) in bioinformatics, drug development, and cutting-edge shared resources. Annual Retreats and bi-monthly Trainees’ Luncheons will allow trainees to showcase their research advances and interact with the Program Co-Directors, the training faculty, the External Advisory Board, and other trainees, including those who have completed training. The curriculum also includes training in scientific communication and a strong base in responsible conduct of research as well as rigor and reproducibility. Trainees will be selected for their academic accomplishments and their dedication to cancer research and will be appointed for 2 years. There is substantial institutional commitment to this Training Program, e.g. salary support for the Program Director, and matching support from the MCC for a fourth predoctoral trainee. Our Cancer Biology Training Program seeks this continuation to continue its contribution to diversity in the next generation of independent investigators working to accomplish NCI’s goal of improving cancer prevention, detection, diagnosis, treatment, and survivorship.