Postdoctoral Training Program in Genomic Medicine

基因组学技术已经足够先进，可以测量细胞中的DNA序列变异和RNA表达。 临床样本。然而，将基因组测量整合到医疗保健中的速度超过了培训 许多医生和科学家没有能力利用这些信息来改善病人的健康。 因此，培养下一代基因组医学的医生和科学家领导者势在必行。我们 我建议更新我们的基因组医学博士后培养计划，重点是转化医学 Jason摩尔，爱德华玫瑰信息学教授，主任 宾夕法尼亚大学生物医学信息学研究所和凯瑟琳内桑森，珍珠巴瑟教授BRCA相关 艾布拉姆森癌症中心副主任。我们为基因组学培训提供基础 医学，适用于医学博士和博士培训的研究员，认识到每个人都可以进入该计划， 不同的技能和经验。必须为所有研究员提供一个强有力的背景框架， 他们可以在基因组医学领域开发令人兴奋的相关项目。学员参加为期两年的 计划，包括教学课程，临床和实验室轮换，互动学习经验， 研究训练。我们需要一个平衡的课程组合，涵盖基因组学的最新进展， 侧重于基因组学在疾病过程中的作用，定量科学，包括生物医学信息学 和生物统计学，科学写作和ELSI问题。39名培训员是根据他们在以下方面的专门知识挑选的： 基因组医学和来自多个部门，这是进一步扩大与临床经验丰富的 提供基因组医学。学员在一个研究项目中由一个平衡的 团队（例如临床医生和基础科学家）在基因组医学方面经验丰富。学员参加临床 旋转设计，让他们的经验，从大规模并行序列的产生， 从数据到数据分析，再到向患者报告结果。学员还参加互动活动， 包括期刊俱乐部、研究进展报告、临床遗传学查房和务虚会。的 结合课程作业，体验式临床轮换，参与互动活动，并指导 研究经验准备我们的医生和科学家在基因组医学的职业生涯。过去 五年来，14人被接受（申请人的42%）进入基因组医学计划-八个 医生，6名科学家，来自宾夕法尼亚大学医学院（9名）和CHOP的10个不同部门和部门 （五）。我们的学员中有9人（64%）是妇女，3人（21%）来自代表性不足的国家 人口。我们有幸吸引了一批非常强大和多样化的学员， 希望能够继续这样做。我们要求继续支持每年有三名受训人员进入， 宾夕法尼亚大学的基因组医学T32博士后培训计划。

Genomics technology is sufficiently advanced to measure DNA sequence variation and RNA expression in clinical samples. However, the integration of genomic measurements into healthcare is outpacing the training of physicians and scientists, and many are ill-equipped to use this information to improve the health of patients. Thus, it is imperative to train the next generation of physician and scientist leaders in Genomic Medicine. We propose to renewal our post-doctoral training program in Genomic Medicine focuses on translational medicine and informatics and is led by Drs. Jason Moore, Edward Rose Professor of Informatics, and Director of the Penn Institute for Biomedical Informatics, and Katherine Nathanson, Pearl Basser Professor of BRCA-Related Research, and Deputy Director, Abramson Cancer Center. We provide a foundation for training in Genomic Medicine, applicable to both MD and PhD trained fellows, recognizing that each may enter the program with different skill sets and experiences. It essential to provide all fellows with a strong background framework so that they can develop exciting and relevant projects in Genomic Medicine. Trainees enroll in a two-year program, including didactic courses, clinical and laboratories rotations, interactive learning experiences and research training. We require a balanced portfolio of courses, which cover the latest advances in genomics, focused on the role of genomics in disease processes, quantitative sciences, including biomedical informatics and biostatistics, scientific writing and ELSI issues. The 39 trainers were selected based on their expertise in Genomic Medicine and come from multiple departments, which is further enlarged with clinicians experienced in the provision of Genomic Medicine. The trainees are dually mentored in a research project by a balanced team (e.g. clinician and basic scientist) experienced in Genomic Medicine. Trainees participate in clinical rotations designed to give them experiences that range from the generation of massively parallel sequence data to data analysis to reporting back the results to patients. Trainees also participate in interactive activities, including a journal club, research in progress presentations, clinical genetics rounds and retreats. The combination of coursework, experiential clinical rotations, participation in interactive activities, and mentored research experience prepares our physicians and scientists for careers in Genomic Medicine. Over the past five years, 14 individuals were accepted (42% of applicants) into the Genomic Medicine program - eight physicians, six scientists, from 10 different departments and divisions at Penn Medicine (nine) and CHOP (five). Nine (64%) of our trainees were women and three (21%) reported coming from underrepresented populations. We have been privileged to attract an exceptionally strong and diverse set of trainees and anticipate continuing to be able to do so. We request continued support for the entry of three trainees a year in the Genomic Medicine T32 post-doctoral training program at the University of Pennsylvania.