Postdoctoral Training Program in Genomic Medicine
基因组医学博士后培养项目
基本信息
- 批准号:10411353
- 负责人:
- 金额:$ 55.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-21 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Genomics technology is sufficiently advanced to measure DNA sequence variation and RNA expression in
clinical samples. However, the integration of genomic measurements into healthcare is outpacing the training
of physicians and scientists, and many are ill-equipped to use this information to improve the health of patients.
Thus, it is imperative to train the next generation of physician and scientist leaders in Genomic Medicine. We
propose to renewal our post-doctoral training program in Genomic Medicine focuses on translational medicine
and informatics and is led by Drs. Jason Moore, Edward Rose Professor of Informatics, and Director of the
Penn Institute for Biomedical Informatics, and Katherine Nathanson, Pearl Basser Professor of BRCA-Related
Research, and Deputy Director, Abramson Cancer Center. We provide a foundation for training in Genomic
Medicine, applicable to both MD and PhD trained fellows, recognizing that each may enter the program with
different skill sets and experiences. It essential to provide all fellows with a strong background framework so
that they can develop exciting and relevant projects in Genomic Medicine. Trainees enroll in a two-year
program, including didactic courses, clinical and laboratories rotations, interactive learning experiences and
research training. We require a balanced portfolio of courses, which cover the latest advances in genomics,
focused on the role of genomics in disease processes, quantitative sciences, including biomedical informatics
and biostatistics, scientific writing and ELSI issues. The 39 trainers were selected based on their expertise in
Genomic Medicine and come from multiple departments, which is further enlarged with clinicians experienced
in the provision of Genomic Medicine. The trainees are dually mentored in a research project by a balanced
team (e.g. clinician and basic scientist) experienced in Genomic Medicine. Trainees participate in clinical
rotations designed to give them experiences that range from the generation of massively parallel sequence
data to data analysis to reporting back the results to patients. Trainees also participate in interactive activities,
including a journal club, research in progress presentations, clinical genetics rounds and retreats. The
combination of coursework, experiential clinical rotations, participation in interactive activities, and mentored
research experience prepares our physicians and scientists for careers in Genomic Medicine. Over the past
five years, 14 individuals were accepted (42% of applicants) into the Genomic Medicine program - eight
physicians, six scientists, from 10 different departments and divisions at Penn Medicine (nine) and CHOP
(five). Nine (64%) of our trainees were women and three (21%) reported coming from underrepresented
populations. We have been privileged to attract an exceptionally strong and diverse set of trainees and
anticipate continuing to be able to do so. We request continued support for the entry of three trainees a year in
the Genomic Medicine T32 post-doctoral training program at the University of Pennsylvania.
基因组学技术已经足够先进,可以测量DNA序列变异和RNA表达
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Katherine L. Nathanson其他文献
Germline POT1 variants can predispose to myeloid and lymphoid neoplasms
生殖系 POT1 变异可易患髓系和淋巴系肿瘤
- DOI:
10.1038/s41375-021-01335-w - 发表时间:
2021-06-30 - 期刊:
- 影响因子:13.400
- 作者:
Tristan L. Lim;David B. Lieberman;Adam R. Davis;Alison W. Loren;Ryan Hausler;Ashkan Bigdeli;Yimei Li;Jacquelyn Powers;Anna Raper;Regeneron Genetics Center;Shannon A. Carty;Katherine L. Nathanson;Adam Bagg;Elizabeth O. Hexner;Kara N. Maxwell;Jennifer J. D. Morrissette;Daria V. Babushok - 通讯作者:
Daria V. Babushok
An evaluation of <em>BRCA1</em> and <em>BRCA2</em> founder mutations penetrance estimates for breast cancer among Ashkenazi Jewish women
- DOI:
10.1097/01.gim.0000151156.14983.08 - 发表时间:
2005-01-01 - 期刊:
- 影响因子:
- 作者:
Monica R. McClain;Katherine L. Nathanson;Glenn E. Palomaki;James E. Haddow - 通讯作者:
James E. Haddow
Molecular Genetics of Pheochromocytoma/Paraganglioma
嗜铬细胞瘤/副神经节瘤的分子遗传学
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Heather Wachtel;Katherine L. Nathanson - 通讯作者:
Katherine L. Nathanson
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification
对超过 40 万名女性的分析为 BRCA1 和 BRCA2 变异分类提供了病例对照证据
- DOI:
10.1038/s41467-025-59979-6 - 发表时间:
2025-05-25 - 期刊:
- 影响因子:15.700
- 作者:
Maria Zanti;Denise G. O’Mahony;Michael T. Parsons;Leila Dorling;Joe Dennis;Nicholas J. Boddicker;Wenan Chen;Chunling Hu;Marc Naven;Kristia Yiangou;Thomas U. Ahearn;Christine B. Ambrosone;Irene L. Andrulis;Antonis C. Antoniou;Paul L. Auer;Caroline Baynes;Clara Bodelon;Natalia V. Bogdanova;Stig E. Bojesen;Manjeet K. Bolla;Kristen D. Brantley;Nicola J. Camp;Archie Campbell;Jose E. Castelao;Melissa H. Cessna;Jenny Chang-Claude;Fei Chen;Georgia Chenevix-Trench;Don M. Conroy;Kamila Czene;Arcangela De Nicolo;Susan M. Domchek;Thilo Dörk;Alison M. Dunning;A. Heather Eliassen;D. Gareth Evans;Peter A. Fasching;Jonine D. Figueroa;Henrik Flyger;Manuela Gago-Dominguez;Montserrat García-Closas;Gord Glendon;Anna González-Neira;Felix Grassmann;Andreas Hadjisavvas;Christopher A. Haiman;Ute Hamann;Steven N. Hart;Mikael B. A. Hartman;Weang-Kee Ho;James M. Hodge;Reiner Hoppe;Sacha J. Howell;Anna Jakubowska;Elza K. Khusnutdinova;Yon-Dschun Ko;Peter Kraft;Vessela N. Kristensen;James V. Lacey;Jingmei Li;Geok Hoon Lim;Sara Lindström;Artitaya Lophatananon;Craig Luccarini;Arto Mannermaa;Maria Elena Martinez;Dimitrios Mavroudis;Roger L. Milne;Kenneth Muir;Katherine L. Nathanson;Rocio Nuñez-Torres;Nadia Obi;Janet E. Olson;Julie R. Palmer;Mihalis I. Panayiotidis;Alpa V. Patel;Paul D. P. Pharoah;Eric C. Polley;Muhammad U. Rashid;Kathryn J. Ruddy;Emmanouil Saloustros;Elinor J. Sawyer;Marjanka K. Schmidt;Melissa C. Southey;Veronique Kiak-Mien Tan;Soo Hwang Teo;Lauren R. Teras;Diana Torres;Amy Trentham-Dietz;Thérèse Truong;Celine M. Vachon;Qin Wang;Jeffrey N. Weitzel;Siddhartha Yadav;Song Yao;Gary R. Zirpoli;Melissa S. Cline;Peter Devilee;Sean V. Tavtigian;David E. Goldgar;Fergus J. Couch;Douglas F. Easton;Amanda B. Spurdle;Kyriaki Michailidou - 通讯作者:
Kyriaki Michailidou
TSLP and IL-7R Variants Are Associated with Persistent Atopic Dermatitis
- DOI:
10.1016/j.jid.2020.05.119 - 发表时间:
2021-02-01 - 期刊:
- 影响因子:
- 作者:
Ronald Berna;Nandita Mitra;Carolyn Lou;Joy Wan;Ole Hoffstad;Bradley Wubbenhorst;Katherine L. Nathanson;David J. Margolis - 通讯作者:
David J. Margolis
Katherine L. Nathanson的其他文献
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{{ truncateString('Katherine L. Nathanson', 18)}}的其他基金
Using Behavioral Economics and Implementation Science to Advance the Use of Genomic Medicine Utilizing an EHR Infrastructure across a Diverse Health System
利用行为经济学和实施科学来推进基因组医学的使用 在多元化的卫生系统中利用 EHR 基础设施
- 批准号:
10518787 - 财政年份:2022
- 资助金额:
$ 55.22万 - 项目类别:
Using Behavioral Economics and Implementation Science to Advance the Use of Genomic Medicine Utilizing an EHR Infrastructure across a Diverse Health System
利用行为经济学和实施科学来推进基因组医学的使用 在多元化的卫生系统中利用 EHR 基础设施
- 批准号:
10701807 - 财政年份:2022
- 资助金额:
$ 55.22万 - 项目类别:
Core C: Immune bioinformatics and biostatistics
核心C:免疫生物信息学和生物统计学
- 批准号:
10005188 - 财政年份:2017
- 资助金额:
$ 55.22万 - 项目类别:
Postdoctoral Training Program in Genomic Medicine
基因组医学博士后培养项目
- 批准号:
10668462 - 财政年份:2017
- 资助金额:
$ 55.22万 - 项目类别:
Core C: Immune bioinformatics and biostatistics
核心C:免疫生物信息学和生物统计学
- 批准号:
10360422 - 财政年份:2017
- 资助金额:
$ 55.22万 - 项目类别:
Investigating the association between the somatic and inherited genetics of pheoc
研究 pheoc 的体细胞和遗传遗传学之间的关联
- 批准号:
8692202 - 财政年份:2014
- 资助金额:
$ 55.22万 - 项目类别:
Inherited genetic variation and predisposition to testicular germ cell tumor
遗传性遗传变异和睾丸生殖细胞肿瘤的易感性
- 批准号:
7930069 - 财政年份:2009
- 资助金额:
$ 55.22万 - 项目类别:
Somatic genetic predictors of response to therapy in metastatic melanoma
转移性黑色素瘤治疗反应的体细胞遗传预测因子
- 批准号:
7496600 - 财政年份:2007
- 资助金额:
$ 55.22万 - 项目类别:
Inherited genetic variation and predisposition to testicular germ cell tumor
遗传性遗传变异和睾丸生殖细胞肿瘤的易感性
- 批准号:
7488876 - 财政年份:2007
- 资助金额:
$ 55.22万 - 项目类别:
Inherited genetic variation and predisposition to testicular germ cell tumor
遗传性遗传变异和睾丸生殖细胞肿瘤的易感性
- 批准号:
7319423 - 财政年份:2007
- 资助金额:
$ 55.22万 - 项目类别:
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