Tissue Pathology Shared Resource

组织病理学共享资源

• 批准号: 10413075
• 负责人: Kar-Ming Fung
• 金额: $ 13.99万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413075
• 关键词: Biomedical Research; Cancer Center; Cancer Center Support Grant; Clinical; Consultations; Cultured Cells; Diagnosis; Doctor of Philosophy; Equipment; Experimental Designs; Fees; Floor; Funding; Goals; Histology; House Staffs; Image Analysis; Immunohistochemistry; In Situ Hybridization; Infrastructure; Institution; Liquid substance; Malignant Female Reproductive System Neoplasm; NCI Center for Cancer Research; Neoplasm Circulating Cells; Pathologist; Pathology; Peer Review; Productivity; Research; Research Personnel; Resource Sharing; Resources; Scanning; Science; Services; Slide; Specimen; Stains; Technical Expertise; Technology; Time; Tissue imaging; Tissues; base; data repository; experience; member; pre-clinical; programs; tissue processing; translational cancer research; tumor

TISSUE PATHOLOGY SHARED RESOURCE – ABSTRACT The Tissue Pathology Shared Resource (TP SR) is a Stephenson Cancer Center (SCC)-managed facility that provides SCC members and other investigators with high-quality histology, immunohistochemistry (IHC) and in situ hybridization (ISH) services, supported by whole slide scanning and image analysis. The TP SR also provides technical consultation on experimental design and interpretation of results. Established in 2012, the TP SR is directed by Kar-Ming Fung, MD, PhD, a board-certified pathologist with over 28 years of experience in diagnosis and tissue-based research. The services and expertise provided by the TP SR are critical to meet the scientific needs and objectives of the SCC. Members in all three of the SCC's research programs use this Shared Resource, with particularly heavy use by members of the Preclinical Translational Cancer Research (PTCR) and Gynecologic Cancers (GC) programs. Since inception, the TP SR has supported numerous NCI and other peer-reviewed funded research for members of these programs (see TP SR Research Strategy section for a full discussion). TP SR equipment and staff are housed in SCC-designated space in the OUHSC's Biomedical Research Center (BRC), providing the 27 BRC-based SCC members with immediate access to this important infrastructure. An additional five SCC members are located in the adjacent Biomedical Sciences Building (BMSB), which has a dedicated internal walkway to BRC. The main tissue processing and imaging activities occupy a total of 655 sf. of SCC-designated space on BRC Floor 4. In 2016, 21 (43%) of the total number of TP SR users (49) were SCC members with peer-reviewed support. The facility also served nine SCC members without peer-reviewed support. SCC members constituted 61% of the total users of the facility, highlighting the high utilization and impact that the facility has on advancing research at the SCC. As is illustrated in the Research Strategy section, SCC member fees for TP SR services are less than or similar to those of surrounding institutions.

组织病理学共享资源-摘要 组织病理学共享资源（TP SR）是斯蒂芬森癌症中心（SCC）管理的机构， 为SCC成员和其他研究人员提供高质量的组织学，免疫组织化学（IHC）和免疫组织化学（ELISA）。 原位杂交（ISH）服务，由全载玻片扫描和图像分析支持。TP SR还 提供有关实验设计和结果解释的技术咨询。成立于2012年， TP SR由具有超过28年经验的委员会认证病理学家Kar-Ming Fung，MD，PhD指导 在诊断和基于组织的研究中。TP SR提供的服务和专业知识对于满足 SCC的科学需求和目标。SCC所有三个研究项目的成员都使用这个 共享资源，临床前转化癌症研究的成员特别大量使用 （PTCR）和妇科癌症（GC）计划。自成立以来，TP SR已经支持了许多NCI 和其他同行评审资助的研究，为这些计划的成员（见TP SR研究战略 一个完整的讨论）。 TP SR设备和工作人员被安置在OUHSC生物医学研究中心的SCC指定空间内 中心（BRC），为27个BRC SCC成员提供立即访问这一重要的 基础设施演进另外五名SCC成员位于相邻的生物医学科学大楼 （BMSB），它有一个专门的内部走道BRC。主要的组织处理和成像活动 共占地655平方英尺。位于BRC四楼的SCC指定空间。 2016年，TP SR用户总数（49）中有21（43%）是SCC成员，并得到了同行评审的支持。 该设施还在没有同行审查支持的情况下为9个SCC成员提供服务。SCC成员占61%， 该设施的用户总数，强调该设施的高利用率和对促进 研究在SCC。如研究策略部分所示，SCC成员对TP SR服务的收费 低于或类似于周围的机构。