UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program

新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划

• 批准号: 9930893
• 负责人: Johnnye L Lewis
• 金额: $ 1.05万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9930893
• 关键词: Address; Affect; Back; Biological; Biological Testing; Biomedical Research; Cancer Center; Characteristics; Chronic Disease; Church; Collaborations; Communication; Communities; Complement; Country; DNA Damage; DNA Repair; Data; Decision Making; Disease; Environment; Environmental Health; Excision; Exposure to; Faculty; Financial compensation; Five-Year Plans; Foundations; Funding; Future; Generations; Goals; Hazardous Substances; Health; Home environment; Human; Immobilization; Immune; Indigenous; Individual; Intervention; Knowledge; Laboratory Study; Learning; Link; Metal exposure; Metals; Mining; Modeling; Movement; Native Americans; Navajo; New Mexico; Outcome; Pathway interactions; Policies; Population; Positioning Attribute; Prevention; Property; Publications; Pueblo Race; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Reduction; Science; Scientist; Site; Superfund; System; Testing; Toxic effect; Toxicology; Training; Translating; Translational Research; Translations; Uncertainty; Universities; Uranium; Water; Work; air monitoring; base; cohort; community living; cost; cost effective; design; environmental toxicology; evidence base; graduate student; hazard; immune function; improved; indigenous community; literacy; member; metal poisoning; next generation; novel; physical property; programs; remediation; response; superfund site; synergism; therapy design; toxicant; tribal community; tribal lands; wasting; water testing

OVERALL – SUMMARY The UNM Metal Exposure and Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program (SRP) and Training Center will focus on risk reduction for Native Americans exposed to hazardous metals mixtures from abandoned uranium mine waste. This will be the ONLY SRP Center focused on risks to Native American communities. Specifically, UNM METALS will focus on site-specific physical/mineralogic/biogeochemical properties of the waste that alter immune function and DNA repair in tribal populations. The biomedical research proposed in UNM METALS focuses on major uncertainties in these exposure:outcome relationships, while environmental projects complement this research by exploiting characteristics that impact mobility and toxicity to develop and test novel cost-effective metals immobilization and removal strategies to reduce risks in ways compatible with tribal culture, and design risk avoidance/warning systems. Recognizing that complete remediation of these sites under CERCLA remains decades away, METALS will use multi-directional community engagement and research translation cores to develop and implement trans-generational approaches to risk communication and risk avoidance that integrate indigenous learning models (e.g. tribal ecological knowledge) and Western science. The METALS Center will integrate training of junior faculty and graduate students with multi-directional training of community members and research staff so that local knowledge of mining impacts and health problems inform air and water monitoring needs to support the environmental and biomedical research projects and build a foundation of transdisciplinary, partnered research for the next generation. METALS will utilize committed pilot funding from the UNM Cancer Center, the HSC Research Office, and our Environmental Health Signature Program to build transdisicplinary partnerships that expand our team to respond to additional health outcomes of community concern. The Center will expand ongoing, developed partnerships with three Native American communities living in close proximity to unique waste sites. The first is Laguna Pueblo living with the abandoned > 8000 acre openpit Jackpile Mine listed on the Superfund National Priorities List, and two Navajo communities living in proximity to two separate sites being addressed through CERCLA assessment as part of the USEPA Congressionally mandated Five-Year Plan to Address Uranium Contamination on the Navajo Nation: Red Water Pond Road adjacent to the North East Church Rock Mine; and Tachee-Blue Gap community living next to the Claim 28 waste site. In summary, we will work closely with communities, tribal and federal agencies to develop informed Superfund prioritization based on site-specific factors identified through our research, and develop solutions that build on site properties to immobilize and remove metals, reduce risk in ways that are holistic, predictable and sustainable, and test biological interventions to reduce toxicity.

总体 - 摘要 西南超级基金的部落土地上的金属暴露和毒性评估 研究计划（SRP）和培训中心将集中于接触的美洲原住民的风险降低 废弃的铀矿物废物的危险金属混合物。这将是唯一专注的SRP中心 面向美洲原住民社区的风险。具体而言，UNM金属将专注于特定地点 在部落中改变免疫功能和DNA修复的废物的物理/矿物学/生物地球化学特性 人群。 UNM金属提出的生物医学研究重点是这些主要不确定性 暴露：结果关系，而环境项目通过利用来完成这项研究 影响流动性和毒性开发和测试新颖具有成本效益的金属固定的特征 并消除以与部落文化兼容的方式降低风险的策略，并设计风险 回避/警告系统。认识到在Cercla下的这些地点的完全补救仍然存在 几十年来，金属将使用多向社区参与和研究翻译核心 开发和实施跨代方法，以进行风险交流和避免风险的避免 土著学习模型（例如部落生态知识）和西方科学。金属中心将 通过对社区成员进行多个方向培训的初级教师和研究生的综合培训 和研究人员，以便当地有关采矿影响和健康问题的知识使空气和水有所帮助 监测需要支持环境和生物医学研究项目，并建立 跨学科的下一代研究。金属将利用从 UNM癌症中心，HSC研究办公室和我们的环境健康签名计划 跨性伙伴关系扩大我们的团队以应对社区的其他健康成果 忧虑。该中心将扩大与三个美国原住民社区的持续发展，发展的伙伴关系 靠近独特的废物站点。首先是Laguna Pueblo与废弃> 8000一起生活 在超级基金国家优先事项列表中列出的英亩开放式大奖矿山和两个纳瓦霍社区居住 靠近两个单独的站点通过CERCLA评估作为USEPA的一部分 国会授权的五年计划应对纳瓦霍国家的铀污染：红色 水池路毗邻东北教堂岩石矿；和开心的蓝色差距社区接下来 索赔28废物网站。总而言之，我们将与社区，部落和联邦机构紧密合作 根据我们的研究确定的特定地点因素，开发了知情的超级基金优先级 开发建立在现场属性上以固定和去除金属的解决方案，以方式降低风险 整体，可预测和可持续性，并测试生物学干预措施以降低毒性。