UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program

新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划

• 批准号: 9930893
• 负责人: Johnnye L Lewis
• 金额: $ 1.05万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9930893
• 关键词: Address; Affect; Back; Biological; Biological Testing; Biomedical Research; Cancer Center; Characteristics; Chronic Disease; Church; Collaborations; Communication; Communities; Complement; Country; DNA Damage; DNA Repair; Data; Decision Making; Disease; Environment; Environmental Health; Excision; Exposure to; Faculty; Financial compensation; Five-Year Plans; Foundations; Funding; Future; Generations; Goals; Hazardous Substances; Health; Home environment; Human; Immobilization; Immune; Indigenous; Individual; Intervention; Knowledge; Laboratory Study; Learning; Link; Metal exposure; Metals; Mining; Modeling; Movement; Native Americans; Navajo; New Mexico; Outcome; Pathway interactions; Policies; Population; Positioning Attribute; Prevention; Property; Publications; Pueblo Race; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Reduction; Science; Scientist; Site; Superfund; System; Testing; Toxic effect; Toxicology; Training; Translating; Translational Research; Translations; Uncertainty; Universities; Uranium; Water; Work; air monitoring; base; cohort; community living; cost; cost effective; design; environmental toxicology; evidence base; graduate student; hazard; immune function; improved; indigenous community; literacy; member; metal poisoning; next generation; novel; physical property; programs; remediation; response; superfund site; synergism; therapy design; toxicant; tribal community; tribal lands; wasting; water testing

OVERALL – SUMMARY The UNM Metal Exposure and Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program (SRP) and Training Center will focus on risk reduction for Native Americans exposed to hazardous metals mixtures from abandoned uranium mine waste. This will be the ONLY SRP Center focused on risks to Native American communities. Specifically, UNM METALS will focus on site-specific physical/mineralogic/biogeochemical properties of the waste that alter immune function and DNA repair in tribal populations. The biomedical research proposed in UNM METALS focuses on major uncertainties in these exposure:outcome relationships, while environmental projects complement this research by exploiting characteristics that impact mobility and toxicity to develop and test novel cost-effective metals immobilization and removal strategies to reduce risks in ways compatible with tribal culture, and design risk avoidance/warning systems. Recognizing that complete remediation of these sites under CERCLA remains decades away, METALS will use multi-directional community engagement and research translation cores to develop and implement trans-generational approaches to risk communication and risk avoidance that integrate indigenous learning models (e.g. tribal ecological knowledge) and Western science. The METALS Center will integrate training of junior faculty and graduate students with multi-directional training of community members and research staff so that local knowledge of mining impacts and health problems inform air and water monitoring needs to support the environmental and biomedical research projects and build a foundation of transdisciplinary, partnered research for the next generation. METALS will utilize committed pilot funding from the UNM Cancer Center, the HSC Research Office, and our Environmental Health Signature Program to build transdisicplinary partnerships that expand our team to respond to additional health outcomes of community concern. The Center will expand ongoing, developed partnerships with three Native American communities living in close proximity to unique waste sites. The first is Laguna Pueblo living with the abandoned > 8000 acre openpit Jackpile Mine listed on the Superfund National Priorities List, and two Navajo communities living in proximity to two separate sites being addressed through CERCLA assessment as part of the USEPA Congressionally mandated Five-Year Plan to Address Uranium Contamination on the Navajo Nation: Red Water Pond Road adjacent to the North East Church Rock Mine; and Tachee-Blue Gap community living next to the Claim 28 waste site. In summary, we will work closely with communities, tribal and federal agencies to develop informed Superfund prioritization based on site-specific factors identified through our research, and develop solutions that build on site properties to immobilize and remove metals, reduce risk in ways that are holistic, predictable and sustainable, and test biological interventions to reduce toxicity.

总体--摘要 UNM对西南(金属)超级基金部落土地的金属暴露和毒性评估 研究计划(SRP)和培训中心将专注于降低暴露于 废弃铀矿废料中的危险金属混合物。这将是唯一一个专注于SRP中心的 关于美洲原住民社区的风险。具体地说，联合国金属理事会将侧重于具体地点。 改变部落免疫功能和DNA修复的废物的物理/矿物学/生物地球化学特性 人口。在《UNM Metals》杂志上提出的生物医学研究集中在这些方面的主要不确定性。 暴露：结果关系，而环境项目通过利用 影响流动性和毒性的特性，以开发和测试新的高性价比金属固定化 和移除策略，以与部落文化兼容的方式降低风险，并设计风险 避让/警告系统。认识到根据CERCLA对这些遗址的完全补救工作仍然存在 几十年后，Metals将使用多方向的社区参与和研究翻译核心来 制定和实施跨代的风险沟通和风险规避方法，将 土著学习模式(例如部落生态知识)和西方科学。金属中心将 将初级教师和研究生培训与社区成员多方位培训相结合 和研究人员，以便当地关于采矿影响和健康问题的知识向空气和水提供信息 监测需要支持环境和生物医学研究项目，并为 面向下一代的跨学科、合作研究。Metals将利用承诺的试点资金 新墨西哥州癌症中心、HSC研究办公室和我们的环境健康签名计划将建立 跨学科伙伴关系，扩大我们的团队，以应对社区更多的健康后果 担忧。该中心将扩大与三个美洲原住民社区正在进行的、发展中的伙伴关系 住在离独特的废墟很近的地方。第一个是拉古纳·普韦布洛，与被遗弃的8000人一起生活 被列入超级基金国家优先事项名单的英亩露天矿，以及两个纳瓦霍社区 靠近作为美国环保局一部分通过CERCLA评估解决的两个独立地点 国会授权的解决纳瓦霍民族铀污染问题的五年计划：红色 与东北教堂石矿毗邻的水塘路；以及旁边居住的Tachee-Blue Gap社区 到索赔28号废品场。总之，我们将与社区、部落和联邦机构密切合作，以 根据我们的研究确定的特定地点因素，制定知情的超级基金优先顺序，以及 开发基于现场属性的解决方案，以固定和移除金属，以下列方式降低风险 全面、可预测和可持续的，并测试减少毒性的生物干预措施。