UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program

新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划

• 批准号: 9544216
• 负责人: Johnnye L Lewis
• 金额: $ 128.77万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9544216
• 关键词: Address; Affect; Air; Back; Biological; Biological Testing; Biomedical Research; Cancer Center; Characteristics; Chronic Disease; Church; Collaborations; Communication; Communities; Complement; Country; DNA Damage; DNA Repair; Data; Decision Making; Disease; Environment; Environmental Health; Excision; Exposure to; Faculty; Financial compensation; Five-Year Plans; Foundations; Funding; Future; Generations; Goals; Hazardous Substances; Health; Home environment; Human; Immobilization; Immune; Indigenous; Individual; Intervention; Knowledge; Laboratory Study; Learning; Link; Metal exposure; Metals; Mining; Modeling; Monitor; Movement; Native Americans; Navajo; New Mexico; Outcome; Pathway interactions; Policies; Population; Positioning Attribute; Prevention; Property; Publications; Pueblo Race; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Reduction; Science; Scientist; Site; Superfund; System; Testing; Toxic effect; Toxicology; Training; Translating; Translational Research; Translations; Uncertainty; Universities; Uranium; Water; Work; base; cohort; community living; cost; cost effective; design; environmental toxicology; evidence base; graduate student; hazard; immune function; improved; indigenous community; literacy; member; metal poisoning; next generation; novel; physical property; programs; remediation; response; superfund site; synergism; therapy design; toxicant; tribal community; tribal lands; wasting

OVERALL – SUMMARY The UNM Metal Exposure and Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program (SRP) and Training Center will focus on risk reduction for Native Americans exposed to hazardous metals mixtures from abandoned uranium mine waste. This will be the ONLY SRP Center focused on risks to Native American communities. Specifically, UNM METALS will focus on site-specific physical/mineralogic/biogeochemical properties of the waste that alter immune function and DNA repair in tribal populations. The biomedical research proposed in UNM METALS focuses on major uncertainties in these exposure:outcome relationships, while environmental projects complement this research by exploiting characteristics that impact mobility and toxicity to develop and test novel cost-effective metals immobilization and removal strategies to reduce risks in ways compatible with tribal culture, and design risk avoidance/warning systems. Recognizing that complete remediation of these sites under CERCLA remains decades away, METALS will use multi-directional community engagement and research translation cores to develop and implement trans-generational approaches to risk communication and risk avoidance that integrate indigenous learning models (e.g. tribal ecological knowledge) and Western science. The METALS Center will integrate training of junior faculty and graduate students with multi-directional training of community members and research staff so that local knowledge of mining impacts and health problems inform air and water monitoring needs to support the environmental and biomedical research projects and build a foundation of transdisciplinary, partnered research for the next generation. METALS will utilize committed pilot funding from the UNM Cancer Center, the HSC Research Office, and our Environmental Health Signature Program to build transdisicplinary partnerships that expand our team to respond to additional health outcomes of community concern. The Center will expand ongoing, developed partnerships with three Native American communities living in close proximity to unique waste sites. The first is Laguna Pueblo living with the abandoned > 8000 acre openpit Jackpile Mine listed on the Superfund National Priorities List, and two Navajo communities living in proximity to two separate sites being addressed through CERCLA assessment as part of the USEPA Congressionally mandated Five-Year Plan to Address Uranium Contamination on the Navajo Nation: Red Water Pond Road adjacent to the North East Church Rock Mine; and Tachee-Blue Gap community living next to the Claim 28 waste site. In summary, we will work closely with communities, tribal and federal agencies to develop informed Superfund prioritization based on site-specific factors identified through our research, and develop solutions that build on site properties to immobilize and remove metals, reduce risk in ways that are holistic, predictable and sustainable, and test biological interventions to reduce toxicity.

总体-摘要 西南部部落土地的UNM金属暴露和毒性评估（金属）超级基金 研究计划（SRP）和培训中心将侧重于降低风险的美洲原住民暴露于 废弃铀矿废料中的有害金属混合物。这将是唯一的SRP中心集中 对美洲原住民社区的风险。具体而言，UNM金属将专注于特定场地 废物的物理/矿物学/地球化学性质改变了部落中的免疫功能和DNA修复， 人口。UNM METALS提出的生物医学研究重点关注这些方面的主要不确定性。 暴露：结果关系，而环境项目通过利用 影响流动性和毒性的特性，以开发和测试新的具有成本效益的金属固定化 和搬迁战略，以减少风险的方式与部落文化兼容，并设计风险 避免/警告系统。认识到根据《综合性环境反应、赔偿和责任法案》对这些场地进行彻底补救仍然是必要的， 几十年后，METALS将利用多方向的社区参与和研究翻译核心， 制定和实施跨代风险沟通和风险规避方法， 土著学习模式（如部落生态知识）和西方科学。金属中心将 初级教师和研究生的综合培训与社区成员的多方位培训 和研究人员，使当地的采矿影响和健康问题的知识，通知空气和水 监测需要支持环境和生物医学研究项目，并建立 跨学科的合作研究。金属将利用承诺的试点资金， UNM癌症中心，HSC研究办公室和我们的环境健康签名计划， 跨学科合作伙伴关系，扩大我们的团队，以应对社区的额外健康成果 关心该中心将扩大与三个美洲原住民社区的持续发展的伙伴关系 生活在独特的垃圾场附近。第一个是拉古纳普韦布洛生活与废弃> 8000 英亩的露天顶桩矿被列入超级基金国家优先事项清单，两个纳瓦霍社区生活在 作为美国环保局的一部分， 国会授权的五年计划，以解决纳瓦霍民族的铀污染：红色 水塘路毗邻东北教堂岩矿;和Tachee-Blue Gap社区生活在旁边 第28章垃圾场总之，我们将与社区、部落和联邦机构密切合作， 根据我们的研究确定的特定地点因素，制定知情的超级基金优先顺序， 开发基于现场特性的解决方案，以消除和去除金属， 全面、可预测和可持续，并测试生物干预措施以减少毒性。