UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
基本信息
- 批准号:9544216
- 负责人:
- 金额:$ 128.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-15 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAirBackBiologicalBiological TestingBiomedical ResearchCancer CenterCharacteristicsChronic DiseaseChurchCollaborationsCommunicationCommunitiesComplementCountryDNA DamageDNA RepairDataDecision MakingDiseaseEnvironmentEnvironmental HealthExcisionExposure toFacultyFinancial compensationFive-Year PlansFoundationsFundingFutureGenerationsGoalsHazardous SubstancesHealthHome environmentHumanImmobilizationImmuneIndigenousIndividualInterventionKnowledgeLaboratory StudyLearningLinkMetal exposureMetalsMiningModelingMonitorMovementNative AmericansNavajoNew MexicoOutcomePathway interactionsPoliciesPopulationPositioning AttributePreventionPropertyPublicationsPueblo RaceResearchResearch PersonnelResearch Project GrantsResourcesRiskRisk ReductionScienceScientistSiteSuperfundSystemTestingToxic effectToxicologyTrainingTranslatingTranslational ResearchTranslationsUncertaintyUniversitiesUraniumWaterWorkbasecohortcommunity livingcostcost effectivedesignenvironmental toxicologyevidence basegraduate studenthazardimmune functionimprovedindigenous communityliteracymembermetal poisoningnext generationnovelphysical propertyprogramsremediationresponsesuperfund sitesynergismtherapy designtoxicanttribal communitytribal landswasting
项目摘要
OVERALL – SUMMARY
The UNM Metal Exposure and Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund
Research Program (SRP) and Training Center will focus on risk reduction for Native Americans exposed to
hazardous metals mixtures from abandoned uranium mine waste. This will be the ONLY SRP Center focused
on risks to Native American communities. Specifically, UNM METALS will focus on site-specific
physical/mineralogic/biogeochemical properties of the waste that alter immune function and DNA repair in tribal
populations. The biomedical research proposed in UNM METALS focuses on major uncertainties in these
exposure:outcome relationships, while environmental projects complement this research by exploiting
characteristics that impact mobility and toxicity to develop and test novel cost-effective metals immobilization
and removal strategies to reduce risks in ways compatible with tribal culture, and design risk
avoidance/warning systems. Recognizing that complete remediation of these sites under CERCLA remains
decades away, METALS will use multi-directional community engagement and research translation cores to
develop and implement trans-generational approaches to risk communication and risk avoidance that integrate
indigenous learning models (e.g. tribal ecological knowledge) and Western science. The METALS Center will
integrate training of junior faculty and graduate students with multi-directional training of community members
and research staff so that local knowledge of mining impacts and health problems inform air and water
monitoring needs to support the environmental and biomedical research projects and build a foundation of
transdisciplinary, partnered research for the next generation. METALS will utilize committed pilot funding from
the UNM Cancer Center, the HSC Research Office, and our Environmental Health Signature Program to build
transdisicplinary partnerships that expand our team to respond to additional health outcomes of community
concern. The Center will expand ongoing, developed partnerships with three Native American communities
living in close proximity to unique waste sites. The first is Laguna Pueblo living with the abandoned > 8000
acre openpit Jackpile Mine listed on the Superfund National Priorities List, and two Navajo communities living
in proximity to two separate sites being addressed through CERCLA assessment as part of the USEPA
Congressionally mandated Five-Year Plan to Address Uranium Contamination on the Navajo Nation: Red
Water Pond Road adjacent to the North East Church Rock Mine; and Tachee-Blue Gap community living next
to the Claim 28 waste site. In summary, we will work closely with communities, tribal and federal agencies to
develop informed Superfund prioritization based on site-specific factors identified through our research, and
develop solutions that build on site properties to immobilize and remove metals, reduce risk in ways that are
holistic, predictable and sustainable, and test biological interventions to reduce toxicity.
总体-摘要
西南部部落土地的UNM金属暴露和毒性评估(金属)超级基金
研究计划(SRP)和培训中心将侧重于降低风险的美洲原住民暴露于
废弃铀矿废料中的有害金属混合物。这将是唯一的SRP中心集中
对美洲原住民社区的风险。具体而言,UNM金属将专注于特定场地
废物的物理/矿物学/地球化学性质改变了部落中的免疫功能和DNA修复,
人口。UNM METALS提出的生物医学研究重点关注这些方面的主要不确定性。
暴露:结果关系,而环境项目通过利用
影响流动性和毒性的特性,以开发和测试新的具有成本效益的金属固定化
和搬迁战略,以减少风险的方式与部落文化兼容,并设计风险
避免/警告系统。认识到根据《综合性环境反应、赔偿和责任法案》对这些场地进行彻底补救仍然是必要的,
几十年后,METALS将利用多方向的社区参与和研究翻译核心,
制定和实施跨代风险沟通和风险规避方法,
土著学习模式(如部落生态知识)和西方科学。金属中心将
初级教师和研究生的综合培训与社区成员的多方位培训
和研究人员,使当地的采矿影响和健康问题的知识,通知空气和水
监测需要支持环境和生物医学研究项目,并建立
跨学科的合作研究。金属将利用承诺的试点资金,
UNM癌症中心,HSC研究办公室和我们的环境健康签名计划,
跨学科合作伙伴关系,扩大我们的团队,以应对社区的额外健康成果
关心该中心将扩大与三个美洲原住民社区的持续发展的伙伴关系
生活在独特的垃圾场附近。第一个是拉古纳普韦布洛生活与废弃> 8000
英亩的露天顶桩矿被列入超级基金国家优先事项清单,两个纳瓦霍社区生活在
作为美国环保局的一部分,
国会授权的五年计划,以解决纳瓦霍民族的铀污染:红色
水塘路毗邻东北教堂岩矿;和Tachee-Blue Gap社区生活在旁边
第28章垃圾场总之,我们将与社区、部落和联邦机构密切合作,
根据我们的研究确定的特定地点因素,制定知情的超级基金优先顺序,
开发基于现场特性的解决方案,以消除和去除金属,
全面、可预测和可持续,并测试生物干预措施以减少毒性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Johnnye L Lewis其他文献
Use of Ages & Stages Questionnaire ™ (ASQ) in a Navajo Population: Comparison With The U.S. Normative Dataset.
年龄和阶段问卷™ (ASQ) 在纳瓦霍人群中的使用:与美国规范数据集的比较。
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Sara S Nozadi;Li Li;Jantina Clifford;Ruofei Du;K. Murphy;Lu Chen;Paula Seanez;C. Burnette;D. MacKenzie;Johnnye L Lewis - 通讯作者:
Johnnye L Lewis
A Transdisciplinary Approach for Studying Uranium Mobility, Exposure, and Human Health Impacts on Tribal Lands in the Southwest United States
研究铀流动性、暴露和人类健康对美国西南部部落土地影响的跨学科方法
- DOI:
10.1007/978-3-030-53893-4_6 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Joseph H. Hoover;A. Bolt;S. Burchiel;J. Cerrato;Erica J. Dashner;E. Erdei;J. Estrella;E. Hayek;L. Hudson;L. Luo;D. Mackenzie;S. Medina;Jodi R. Schilz;C. A. Velasco;K. Zychowski;Johnnye L Lewis - 通讯作者:
Johnnye L Lewis
Inhalation of Uranium Oxide Aerosols: CNS Deposition, Neurotoxicity, and Role in Gulf War Illness
吸入氧化铀气溶胶:中枢神经系统沉积、神经毒性以及在海湾战争疾病中的作用
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
Johnnye L Lewis;G. Bench;F. Hahn - 通讯作者:
F. Hahn
Johnnye L Lewis的其他文献
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{{ truncateString('Johnnye L Lewis', 18)}}的其他基金
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9903340 - 财政年份:2017
- 资助金额:
$ 128.77万 - 项目类别:
Promoting Diversity in the UNM METALS SRC through Risk-Reduction Research on Tribal Lands
通过部落土地风险降低研究促进 UNM METALS SRC 的多样性
- 批准号:
10395130 - 财政年份:2017
- 资助金额:
$ 128.77万 - 项目类别:
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9930893 - 财政年份:2017
- 资助金额:
$ 128.77万 - 项目类别:
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地的金属暴露和毒性评估 (METALS) 超级基金研究计划
- 批准号:
10353201 - 财政年份:2017
- 资助金额:
$ 128.77万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10191069 - 财政年份:2016
- 资助金额:
$ 128.77万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10205869 - 财政年份:2016
- 资助金额:
$ 128.77万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10415881 - 财政年份:2016
- 资助金额:
$ 128.77万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10745236 - 财政年份:2016
- 资助金额:
$ 128.77万 - 项目类别:
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