Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
基本信息
- 批准号:10205869
- 负责人:
- 金额:$ 32.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAfrican AmericanBirthCOVID-19COVID-19 pandemicCaregiver BurdenCaregiversChildChild HealthChild RearingCitiesCohort StudiesCollectionCommunitiesConsentDataData CollectionData SetDevelopmentDisastersDiscriminationEnsureEnvironmentFamilyFrequenciesFutureGovernmentHome environmentIndigenousInfrastructureInternetInterventionKnowledgeLifeMeasuresMetabolic syndromeMetal exposureMethodsMinorityNative AmericansNative-BornNatural experimentNavajoNeeds AssessmentOutcomeParticipantPopulationPreparationPrevalenceProtocols documentationReproducibilityResearchRiskSchoolsServicesSiteSouth DakotaStressSystemTestingTimeTrainingTraumaVisitVulnerable Populationscohortcoronavirus diseasedata exchangedata portalexperienceimmunoregulationinfection rateinsightmembermortalityneurodevelopmentnon-Nativepandemic diseaseracismresponsescreeningsocial exclusionstressorsuccesstoxicant
项目摘要
Project Summary
Available knowledge about how stress in the home environment influences child neurodevelopment points to
the importance of capturing time-sensitive data on major stressors, such as the COVID-19 pandemic, across
the many populations represented in ECHO. The collective ECHO data offers insight into an unfortunate
natural experiment on how such a major stress affects ECHO children and families. Understanding this will
allow for better preparation to meet the needs of affected children as they re-enter school and community life,
while helping to mitigate the impacts of similar stressors in future disasters affecting children. Minority and
marginalized populations are representative of US population prevalence in ECHO, but the total number of any
group within the 55,000 ECHO children may still be relatively small. For example, most Native American ECHO
participants are in 2 cohorts, and represent fewer than 1500 of the 55,000 children in ECHO. It is conceivable
that time-sensitive measures such as responses to ECHO will be captured in very few, or none, of the ECHO
participants within marginalized populations most affected.
This ECHO NOSI application examines the relative pandemic-induced stress across multiple cohorts differing
with respect to marginalization, COVID-19 population prevalence, and experience with historical
trauma/systemic racism. At present, this comparison includes the Navajo Birth Cohort Study/ECHO
(NBCS/ECHO) cohort, the PASS ECHO cohorts (Indigenous and non-Indigenous populations in South
Dakota), and the Atlanta ECHO cohort of urban Black participants. We propose three aims to address our
overall hypothesis that pandemic-induced stress will be greatest in populations experiencing the greatest rates
of infection and mortality, but exacerbated by historical trauma in Indigenous and Black populations. Aim 1 will
ensure availability of time-sensitive data to test this hypothesis in the future; Aim 2 will expand the
opportunities for remote and lay staff collection of neurodevelopmental data to ensure availability for testing the
hypothesis, and Aim 3 will test and develop a reliable system for transfer of NBCS data to the DAC NBCS
portal at greater frequency than is currently possible with infrastructure limits.
This is the first study exploring the impact of increased stress across communities already affected by historical
trauma and facing a disaster like COVID-19 to address whether collective stress affects long-term child
neurodevelopment through changes in parenting and the home environment, and will ensure minority cohorts
are represented in the time-sensitive datasets in sufficient numbers to evaluate and compare impacts to
develop mitigation interventions, rather than simply by population proportional representation.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Johnnye L Lewis其他文献
Use of Ages & Stages Questionnaire ™ (ASQ) in a Navajo Population: Comparison With The U.S. Normative Dataset.
年龄和阶段问卷™ (ASQ) 在纳瓦霍人群中的使用:与美国规范数据集的比较。
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Sara S Nozadi;Li Li;Jantina Clifford;Ruofei Du;K. Murphy;Lu Chen;Paula Seanez;C. Burnette;D. MacKenzie;Johnnye L Lewis - 通讯作者:
Johnnye L Lewis
A Transdisciplinary Approach for Studying Uranium Mobility, Exposure, and Human Health Impacts on Tribal Lands in the Southwest United States
研究铀流动性、暴露和人类健康对美国西南部部落土地影响的跨学科方法
- DOI:
10.1007/978-3-030-53893-4_6 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Joseph H. Hoover;A. Bolt;S. Burchiel;J. Cerrato;Erica J. Dashner;E. Erdei;J. Estrella;E. Hayek;L. Hudson;L. Luo;D. Mackenzie;S. Medina;Jodi R. Schilz;C. A. Velasco;K. Zychowski;Johnnye L Lewis - 通讯作者:
Johnnye L Lewis
Inhalation of Uranium Oxide Aerosols: CNS Deposition, Neurotoxicity, and Role in Gulf War Illness
吸入氧化铀气溶胶:中枢神经系统沉积、神经毒性以及在海湾战争疾病中的作用
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
Johnnye L Lewis;G. Bench;F. Hahn - 通讯作者:
F. Hahn
Johnnye L Lewis的其他文献
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{{ truncateString('Johnnye L Lewis', 18)}}的其他基金
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9903340 - 财政年份:2017
- 资助金额:
$ 32.09万 - 项目类别:
Promoting Diversity in the UNM METALS SRC through Risk-Reduction Research on Tribal Lands
通过部落土地风险降低研究促进 UNM METALS SRC 的多样性
- 批准号:
10395130 - 财政年份:2017
- 资助金额:
$ 32.09万 - 项目类别:
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9544216 - 财政年份:2017
- 资助金额:
$ 32.09万 - 项目类别:
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9930893 - 财政年份:2017
- 资助金额:
$ 32.09万 - 项目类别:
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地的金属暴露和毒性评估 (METALS) 超级基金研究计划
- 批准号:
10353201 - 财政年份:2017
- 资助金额:
$ 32.09万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10191069 - 财政年份:2016
- 资助金额:
$ 32.09万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10415881 - 财政年份:2016
- 资助金额:
$ 32.09万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10745236 - 财政年份:2016
- 资助金额:
$ 32.09万 - 项目类别:
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