UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地的金属暴露和毒性评估 (METALS) 超级基金研究计划
基本信息
- 批准号:10353201
- 负责人:
- 金额:$ 183.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-15 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeAgricultureArsenicArtsAutoantibodiesBeliefBiologicalBiological AvailabilityBiological MonitoringBioreactorsBioremediationsCellsChronicChronic DiseaseClinicalClinical TrialsCollaborationsCommunitiesCongressesDNA RepairDataDevelopmentDoseEconomicsEnsureEnvironmentEquilibriumExposure toFamilyFundingHealthHomeHypertensionImmuneImmune System DiseasesImmunityIndigenousInflammationInflammatoryIngestionInhalationInterventionLanguageLeadLeftLinkLungMetabolic BiotransformationMetal exposureMetalsMiningModelingMovementNative-BornNavajoNew MexicoNuclear WeaponOralOxidative StressParticulatePathway interactionsPhasePlantsPoliciesPolicy MakerPopulationPrevalenceProcessProductionPropertyPueblo RaceReference ValuesResearchResearch PersonnelResourcesRestRiskRisk ReductionRoleRouteSafetyScienceSignal Recognition ParticleSiteSuperfundSymbiosisTestingThinkingTimeTissuesToxic effectTranslationsTransmission Electron MicroscopyUniversitiesUraniumVanadiumWarWeatherWorkZincbasecommunity partnershipcost effectivecytokinedesigndisorder riskexposure routefederal policygeochemistryimmune functionimprovedmetal complexmetal poisoningmultidisciplinarymultimodalitynanoparticlenovelnovel strategiesparticlephysical propertyplant fungiprogramsremediationresponsesoundtherapy designtoxic metaltranslational approachtribal landsuptakevulnerable communitywastingweapons
项目摘要
OVERALL Summary METALS
The UNM Metal Exposure and Toxicity Assessment on tribal Lands of the Southwest SRP Center
(METALS) focuses on >500 abandoned uranium mines (AUMs) on Navajo Nation, and the Jackpile Mine on
Laguna Pueblo, a legacy of the Cold War now being assessed under CERCLA. They represent >4500 AUMs
in the 15 Western US that are home to >1/2 of our Indigenous population. During the inaugural phase of
METALS, our team worked in close partnership with our Indigenous partners to determine that since mining
began in the 1940s, weathering of metal mixtures in the millions of tons of waste has produced nanoparticles
of varying mineralogy. While these nanoparticles have implications for both mobility and toxicity of the waste,
they are not considered in prioritization or clean-up due to significant data gaps. Our health studies have
shown that exposures to these metal mixtures increase the prevalence of hypertension, multiple chronic
diseases, and immune dysfunction, and autoantibody production. While ~25% of the population shows no
evidence of exposures, biomonitoring confirms an equivalent %age show exposure to clusters of up to 12
metals at significantly higher concentrations than the rest of the US population. Our community-partnered
approach and strong team integration inclusive of community partners has allowed our design of clinical
interventions that are scientifically sound and respectful of culture, in which we have high rates of participation
and compliance. Phase 2 of METALS will build on our strong community partnerships to drive our research by
their needs, and use single atom, state of the science, transmission electron microscopy to both answer
community questions on agricultural safety as impacted by particulate redistribution, and understand the
processes of resuspension, environmental mobility, and plant uptake at a mechanistic scale to inform risk
reduction. Our confirmation of multiple routes of exposures, and evidence of metals-induced inflammation and
oxidative stress lead us to examine contributions of ingestion and inhalation within community exposures.
These studies will explore the potential for high-dose exposures to immune regulatory cells in lung and gut to
alter systemic immune function, informing design of more targeted intervention. Our recognition of the role of
plant/fungi symbiosis in transformation of environmental metal mixtures has led to our collaboration with the
national Sevilleta Long Term Ecological Research program in New Mexico in development and testing of
fungal bioreactors based in the balance of native fungal communities and their interactions with geochemical
variables as a remediation strategy. These remediation approaches provide a novel strategy to overcome the
ineffectiveness of bacterial bioreactors in our oxic environment and produce sustainable, cost-effective
solutions to protect key resources of cultural importance. Our team will build on our strong partnerships to
build common dialogue with communities, researchers, clinicians, tribal and federal policy makers, informed by
our solution-oriented team science to inform risk reduction at community, clinical and policy levels.
金属概述
西南SRP中心部落土地的UNM金属暴露和毒性评估
(金属)专注于纳瓦霍民族的>500个废弃铀矿(AUM),以及
拉古纳普韦布洛,冷战的遗产,现在正在评估根据综合性环境反应、赔偿和责任法案。他们代表>4500 AUM
在美国西部的15个地区,超过1/2的土著人口居住在那里。在成立阶段,
金属,我们的团队与我们的土著合作伙伴密切合作,以确定自采矿以来
从20世纪40年代开始,数百万吨废物中的金属混合物风化产生了纳米颗粒
不同的矿物。虽然这些纳米颗粒对废物的流动性和毒性都有影响,
由于数据差距很大,在确定优先次序或进行清理时没有考虑这些问题。我们的健康研究
暴露于这些金属混合物会增加高血压、多种慢性
疾病、免疫功能障碍和自身抗体产生。虽然约25%的人口显示没有
暴露证据,生物监测证实,
金属的浓度明显高于美国其他地区的人口。我们的社区合作伙伴
方法和强大的团队整合,包括社区合作伙伴,使我们的临床设计
科学合理和尊重文化的干预措施,我们参与率很高
和遵守。第二阶段的金属将建立在我们强大的社区合作伙伴关系,以推动我们的研究,
他们的需要,并使用单原子,国家的科学,透射电子显微镜,以两者的答案
社区对农业安全的问题,因为颗粒物再分布的影响,并了解
再悬浮、环境流动性和植物吸收的过程,以告知风险
还原我们确认了多种暴露途径,以及金属诱导炎症的证据,
氧化应激导致我们研究摄入和吸入在社区暴露中的作用。
这些研究将探索高剂量暴露于肺和肠道中的免疫调节细胞,
改变全身免疫功能,为设计更有针对性的干预措施提供信息。我们认识到,
植物/真菌共生在环境金属混合物的转化导致了我们的合作,
国家塞维利亚长期生态研究计划在新墨西哥州的发展和测试,
基于天然真菌群落平衡及其与地球化学的相互作用的真菌生物反应器
变量作为补救策略。这些补救方法提供了一种新的策略,以克服
细菌生物反应器在我们的氧化环境中的无效性,并产生可持续的,具有成本效益的
保护具有重要文化意义的关键资源。我们的团队将建立在我们强大的合作伙伴关系,
与社区、研究人员、临床医生、部落和联邦政策制定者建立共同对话,
我们以解决方案为导向的团队科学,为社区,临床和政策层面的风险降低提供信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Johnnye L Lewis其他文献
Use of Ages & Stages Questionnaire ™ (ASQ) in a Navajo Population: Comparison With The U.S. Normative Dataset.
年龄和阶段问卷™ (ASQ) 在纳瓦霍人群中的使用:与美国规范数据集的比较。
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Sara S Nozadi;Li Li;Jantina Clifford;Ruofei Du;K. Murphy;Lu Chen;Paula Seanez;C. Burnette;D. MacKenzie;Johnnye L Lewis - 通讯作者:
Johnnye L Lewis
A Transdisciplinary Approach for Studying Uranium Mobility, Exposure, and Human Health Impacts on Tribal Lands in the Southwest United States
研究铀流动性、暴露和人类健康对美国西南部部落土地影响的跨学科方法
- DOI:
10.1007/978-3-030-53893-4_6 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Joseph H. Hoover;A. Bolt;S. Burchiel;J. Cerrato;Erica J. Dashner;E. Erdei;J. Estrella;E. Hayek;L. Hudson;L. Luo;D. Mackenzie;S. Medina;Jodi R. Schilz;C. A. Velasco;K. Zychowski;Johnnye L Lewis - 通讯作者:
Johnnye L Lewis
Inhalation of Uranium Oxide Aerosols: CNS Deposition, Neurotoxicity, and Role in Gulf War Illness
吸入氧化铀气溶胶:中枢神经系统沉积、神经毒性以及在海湾战争疾病中的作用
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
Johnnye L Lewis;G. Bench;F. Hahn - 通讯作者:
F. Hahn
Johnnye L Lewis的其他文献
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{{ truncateString('Johnnye L Lewis', 18)}}的其他基金
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9903340 - 财政年份:2017
- 资助金额:
$ 183.9万 - 项目类别:
Promoting Diversity in the UNM METALS SRC through Risk-Reduction Research on Tribal Lands
通过部落土地风险降低研究促进 UNM METALS SRC 的多样性
- 批准号:
10395130 - 财政年份:2017
- 资助金额:
$ 183.9万 - 项目类别:
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9544216 - 财政年份:2017
- 资助金额:
$ 183.9万 - 项目类别:
UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
新墨西哥大学西南部部落土地金属暴露毒性评估 (METALS) 超级基金研究计划
- 批准号:
9930893 - 财政年份:2017
- 资助金额:
$ 183.9万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10191069 - 财政年份:2016
- 资助金额:
$ 183.9万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10205869 - 财政年份:2016
- 资助金额:
$ 183.9万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10415881 - 财政年份:2016
- 资助金额:
$ 183.9万 - 项目类别:
Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
了解环境对美国原住民儿童健康轨迹的风险梯度:毒物、免疫调节、代谢综合征、
- 批准号:
10745236 - 财政年份:2016
- 资助金额:
$ 183.9万 - 项目类别:
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