Postdoctoral Training Program in Genomic Medicine

项目总结/摘要 这是一个新的基因组医学博士后培训计划（T32）的申请。我们提出了两 研究生职位，以支持从事医学遗传学研究的医生科学家。 医学遗传学家太少，无法满足日益增长的服务需求。因此，许多医疗 遗传学测试、诊断、咨询和管理发生在我们的领域之外，而是在实践中进行的。 由几乎没有接受过专门培训的医生组成。因此，我们的目标是双重的：首先，指导未来的医疗 遗传学家开始了学术医学的职业生涯，因此发展了医学遗传学。 劳动力;第二，为从事其他领域的医生-科学家提供医学遗传学培训 在医学遗传学相关的研究，这将提高这些专家的临床知识基础， 可能最有可能在他们的实践中使用基因检测或治疗。本提案的具体目标 包括：1）受保护的指导研究经验与成熟的研究人员进行研究， 医学遗传学在华盛顿大学医学院，2）义务教育计划， 实验室管理、科学严谨性、统计学、计量学、负责任的研究行为，以及 生物医学信息学3）根据学员的调查领域个性化的具体课程，4） 持续反馈给学员、导师和项目领导，以及5）学员的发展， 残疾人、弱势背景和代表性不足的少数群体。学员可以从四个选项中选择 代表患者护理需求增长特别快的重点领域：癌症、罕见和未确诊 疾病，基因-环境相互作用和神经退行性变。项目主任帕特里夏·迪克森将 与联合主任Jorge Di保拉密切合作，选择和监督基因组学未来领导者的培训 药该计划的主要优势包括积极的医学和实验室遗传学培训计划，在 拥有临床细胞遗传学实验室、生化实验室和测序能力， 进行基因组研究的中心和团体，包括未诊断疾病网络临床和模型 微生物筛查中心网站，麦克唐纳基因组研究所，癌症图谱网络，爱迪生 基因组科学与系统生物学家庭中心等。华盛顿大学提供了一个 优秀的指导环境和遗传学研究的基础设施，重点是 合作和生产医生科学家的极好记录。该提案将利用 遗传学研究，临床和研究培训的财富，以及在我们校园蓬勃发展的导师， 培训那些将创新诊断，治疗和数据驱动的实践带到诊所的科学家。

PROJECT SUMMARY/ABSTRACT This is an application for a new Postdoctoral Training Program in Genomic Medicine (T32). We propose two postgraduate positions per year to support physician-scientists who are engaging in medical genetics research. There are too few medical geneticists to meet the growing need for our services. As a result, much of medical genetics testing, diagnosis, counseling, and management occurs outside of our field and is instead practiced by physicians who receive little specific training. Our goals are therefore twofold: first, to mentor future medical geneticists who are embarking on a career in academic medicine and therefore grow the medical genetics workforce; and secondly, to provide medical genetics training to physician-scientists in other fields who engage in medical genetics-related research, which will enhance the clinical knowledge-base of those specialists who may be most likely to use genetic testing or treatments in their practices. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators performing research in medical genetics within the Washington University School of Medicine, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship, responsible conduct of research, and biomedical informatics 3) individualized specific coursework based on the trainees’ areas of investigation, 4) continuous feedback to the trainees, mentors and program leadership, and 5) the development of trainees with disabilities, disadvantaged backgrounds, and underrepresented minorities. Trainees may choose from four focus areas, which represent patient care needs with particularly rapid growth: Cancer, Rare and Undiagnosed Diseases, Gene-Environment Interaction, and Neurodegeneration. The program director, Patricia Dickson, will work closely with co-director Jorge Di Paola to select and oversee training of future leaders in genomic medicine. Major strengths of this program include active medical and laboratory genetics training programs, in- house clinical cytogenetics laboratory, biochemical laboratory, and sequencing capability, a large number of centers and groups performing genomic studies, including Undiagnosed Diseases Network clinical and model organism screening center sites, the McDonnell Genome Institute, the Cancer Atlas Network, the Edison Family Center for Genome Sciences & Systems Biology, and others. Washington University provides an outstanding mentorship environment and infrastructure for genetics research, with an emphasis on collaboration and a superb track record of producing physician-scientists. This proposal will take advantage of the wealth of genetics research, clinical and research training, and mentorship that is thriving on our campus to train those scientists who will bring innovative diagnostics, therapeutics, and data-driven practice to the clinic.