Postdoctoral Training Program in Genomic Medicine

项目摘要/摘要 这是一个新的基因医学博士后培训计划(T32)的申请书。我们建议两个 每年提供研究生职位，以支持从事医学遗传学研究的内科科学家。 医学遗传学家太少，无法满足对我们服务日益增长的需求。因此，大部分医疗保健 遗传学测试、诊断、咨询和管理在我们的领域之外进行，而是在实践中进行 由几乎没有接受过专门培训的医生进行。因此，我们的目标有两个：第一，指导未来的医疗 遗传学家，他们开始从事学术医学事业，因此发展了医学遗传学 第二，为从事其他领域的医学科学家提供医学遗传学培训 在与医学遗传学相关的研究中，这将增强以下专家的临床知识基础 可能最有可能在他们的实践中使用基因测试或治疗。这项建议的具体目的 包括：1)由知名研究人员在以下领域进行研究的受保护的指导研究经验 华盛顿大学医学院的医学遗传学，2)必修教育项目 实验室管理、科学严谨性、统计学、专业精神、负责任的研究行为，以及 生物医学信息学3)根据学员的研究领域进行个性化的具体课程作业，4) 持续向学员、导师和项目领导提供反馈，以及5)学员的发展 残疾人、弱势背景和代表性不足的少数群体。学员可从四个选项中选择 重点领域，代表患者护理需求增长特别快的领域：癌症，罕见和未确诊 疾病、基因-环境相互作用和神经退行性变。节目总监帕特里夏·迪克森将 与联合主任豪尔赫·迪·保拉密切合作，挑选和监督基因组学未来领导者的培训 医药。该计划的主要优势包括积极的医学和实验室遗传学培训计划，在- 豪斯临床细胞遗传学实验室、生化实验室、测序能力强、数量众多 进行基因组研究的中心和小组，包括未诊断疾病网络临床和模型 生物筛选中心、麦克唐纳基因组研究所、癌症图谱网络、爱迪生 基因组科学和系统生物学家庭中心，以及其他。华盛顿大学提供了一个 优秀的遗传学研究导师环境和基础设施，重点是 合作和培养内科科学家的卓越记录。这项建议将利用 遗传学研究、临床和研究培训的财富，以及在我们校园蓬勃发展的导师关系 培训那些将把创新的诊断、治疗和数据驱动实践带到临床的科学家。

PROJECT SUMMARY/ABSTRACT This is an application for a new Postdoctoral Training Program in Genomic Medicine (T32). We propose two postgraduate positions per year to support physician-scientists who are engaging in medical genetics research. There are too few medical geneticists to meet the growing need for our services. As a result, much of medical genetics testing, diagnosis, counseling, and management occurs outside of our field and is instead practiced by physicians who receive little specific training. Our goals are therefore twofold: first, to mentor future medical geneticists who are embarking on a career in academic medicine and therefore grow the medical genetics workforce; and secondly, to provide medical genetics training to physician-scientists in other fields who engage in medical genetics-related research, which will enhance the clinical knowledge-base of those specialists who may be most likely to use genetic testing or treatments in their practices. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators performing research in medical genetics within the Washington University School of Medicine, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship, responsible conduct of research, and biomedical informatics 3) individualized specific coursework based on the trainees’ areas of investigation, 4) continuous feedback to the trainees, mentors and program leadership, and 5) the development of trainees with disabilities, disadvantaged backgrounds, and underrepresented minorities. Trainees may choose from four focus areas, which represent patient care needs with particularly rapid growth: Cancer, Rare and Undiagnosed Diseases, Gene-Environment Interaction, and Neurodegeneration. The program director, Patricia Dickson, will work closely with co-director Jorge Di Paola to select and oversee training of future leaders in genomic medicine. Major strengths of this program include active medical and laboratory genetics training programs, in- house clinical cytogenetics laboratory, biochemical laboratory, and sequencing capability, a large number of centers and groups performing genomic studies, including Undiagnosed Diseases Network clinical and model organism screening center sites, the McDonnell Genome Institute, the Cancer Atlas Network, the Edison Family Center for Genome Sciences & Systems Biology, and others. Washington University provides an outstanding mentorship environment and infrastructure for genetics research, with an emphasis on collaboration and a superb track record of producing physician-scientists. This proposal will take advantage of the wealth of genetics research, clinical and research training, and mentorship that is thriving on our campus to train those scientists who will bring innovative diagnostics, therapeutics, and data-driven practice to the clinic.