Alzheimer’s Disease and Related Dementias (ADRD) Prevention and Research among Middle Age Latinas residing in an Underserved Agricultural Community

获得资助的赠款或项目的摘要或摘要。 家长奖助金项目旨在了解社会和环境的独特和综合影响 影响ADRDS风险的因素及相关机制。我们建议利用来自 萨利纳斯母亲和儿童健康评估中心(CHAMACOS)对大约550项研究 即将步入中年的拉丁裔女性(平均年龄=47岁)。研究社会和社会之间的联系 针对拉美裔的逆境、农药暴露和ADRDS风险，我们的具体目标是： 1.量化早年和中年社会逆境与认知表现之间的关系 在中年拉美裔女性中的比例以及这些联系的解释程度 心脏代谢和炎症机制。从生命历程的角度来看，我们 假设早年和中年的逆境都会导致认知能力下降 结果，但经历了这两种情况的女性在中年将处于最不利的认知状态。我们也 预计心脏代谢风险因素和炎症将部分调节任何观察到的 联想。 2.评估农业农药暴露与认知表现之间的关系 评估社会逆境和接触杀虫剂是否会产生较差的认知能力 中年拉美裔女性的结局。我们假设，通过两种方法评估的农药暴露 区域水平的指标和个体生物标记物，将对中年认知结果产生不利影响。知情者 通过暴露-应激-疾病框架，我们进一步假设农药暴露和社会 逆境结合起来会产生更差的认知结果。 3.评估生活经历、社会逆境、农药暴露与大脑的关系 中年拉丁裔女性中的生物标志物。我们将测量大脑的总体积和区域体积以及白质 通过磁共振成像(MRI)对200名女性子组进行物质高强度检查。处于探索性阶段 分析，我们还将评估社会逆境和/或农药暴露是否会改变关联 大脑结构、病理和认知表现之间的关系。

Summary or abstract of the funded grant or project. The parent grant project aims to understand the unique and combined impacts of social and environmental factors on ADRDs risk and relevant mechanisms. We propose to leverage a well-established cohort from The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study of approximately 550 Latina women who are entering mid-life (mean = 47 years old). To study the associations between social adversity, pesticide exposures, and ADRDs risk among Latinos, our Specific Aims are: 1. To quantify associations between early and mid-life social adversity and cognitive performance among mid-life Latina women and the extent to which these associations are explained by cardiometabolic and inflammatory mechanisms. Informed by the life course perspective, we hypothesize that early and mid-life adversity will each independently contribute to poorer cognitive outcomes, but that women who experience both will be most cognitive disadvantaged in mid-life. We also expect that cardio-metabolic risk factors and inflammation will partially mediate any observed associations. 2. To estimate associations between agricultural pesticide exposure and cognitive performance and to evaluate whether social adversity and pesticide exposure interact to produce poorer cognitive outcomes among mid-life Latina women. We hypothesize that pesticide exposure, evaluated via both area- level metrics and individual biomarkers, will adversely impact mid-life cognitive outcomes. Informed by an exposure-stress-disease framework, we further hypothesize that pesticide exposure and social adversity will combine to produce poorer cognitive outcomes. 3. To evaluate relationships between life course social adversity, pesticide exposure, and brain biomarkers among mid-life Latina women. We will measure total brain and regional volume and white matter hyper-intensities via magnetic resonance imaging (MRI) on a subset of 200 women. In exploratory analyses, we will also evaluate whether social adversity and/or pesticide exposure modify associations between brain structure, pathology, and cognitive performance.