Alzheimer’s Disease and Related Dementias (ADRD) Prevention and Research among Middle Age Latinas residing in an Underserved Agricultural Community

资助的赠款或项目的摘要或摘要。 家长资助项目旨在了解社会和环境的独特和综合影响 ADRD的危险因素及相关机制。我们建议利用一个成熟的队列， 萨利纳斯母亲和儿童健康评估中心（CHAMACOS）对大约550名 进入中年的拉丁裔妇女（平均年龄= 47岁）。为了研究人类社会 逆境，农药暴露和拉丁美洲人的ADRD风险，我们的具体目标是： 1.量化早期和中年社会逆境与认知表现之间的关联 在中年拉丁妇女中，这些协会在多大程度上被解释为 心脏代谢和炎症机制。从生命历程的角度来看，我们 假设早期和中期的逆境将各自独立地导致认知能力下降， 结果，但经历这两种情况的女性在中年时将处于最不利的认知地位。我们也 预计心脏代谢危险因素和炎症将部分介导任何观察到的 协会. 2.评估农业农药暴露与认知表现之间的关联， 评估社会逆境和农药暴露是否相互作用， 中年拉丁妇女的结果。我们假设，通过两种方法评估的农药暴露， 区域水平指标和个体生物标志物，将对中年认知结果产生不利影响。知情 通过一个确定性-压力-疾病的框架，我们进一步假设农药暴露和社会因素 逆境将联合收割机结合起来，产生更差的认知结果。 3.评估生命历程、社会逆境、农药暴露和大脑之间的关系 中年拉丁妇女的生物标志物。我们将测量整个大脑和局部体积白色 通过磁共振成像（MRI）对200名女性的子集进行高强度检查。的在试探性 分析，我们还将评估是否社会逆境和/或农药暴露修改协会 大脑结构病理和认知能力之间的联系

Summary or abstract of the funded grant or project. The parent grant project aims to understand the unique and combined impacts of social and environmental factors on ADRDs risk and relevant mechanisms. We propose to leverage a well-established cohort from The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study of approximately 550 Latina women who are entering mid-life (mean = 47 years old). To study the associations between social adversity, pesticide exposures, and ADRDs risk among Latinos, our Specific Aims are: 1. To quantify associations between early and mid-life social adversity and cognitive performance among mid-life Latina women and the extent to which these associations are explained by cardiometabolic and inflammatory mechanisms. Informed by the life course perspective, we hypothesize that early and mid-life adversity will each independently contribute to poorer cognitive outcomes, but that women who experience both will be most cognitive disadvantaged in mid-life. We also expect that cardio-metabolic risk factors and inflammation will partially mediate any observed associations. 2. To estimate associations between agricultural pesticide exposure and cognitive performance and to evaluate whether social adversity and pesticide exposure interact to produce poorer cognitive outcomes among mid-life Latina women. We hypothesize that pesticide exposure, evaluated via both area- level metrics and individual biomarkers, will adversely impact mid-life cognitive outcomes. Informed by an exposure-stress-disease framework, we further hypothesize that pesticide exposure and social adversity will combine to produce poorer cognitive outcomes. 3. To evaluate relationships between life course social adversity, pesticide exposure, and brain biomarkers among mid-life Latina women. We will measure total brain and regional volume and white matter hyper-intensities via magnetic resonance imaging (MRI) on a subset of 200 women. In exploratory analyses, we will also evaluate whether social adversity and/or pesticide exposure modify associations between brain structure, pathology, and cognitive performance.