Alzheimer’s Disease and Related Dementias (ADRD) Prevention and Research among Middle Age Latinas residing in an Underserved Agricultural Community
Alzheimer’s Disease and Related Dementias (ADRD) Prevention and Research among Middle Age Latinas residing in an Underserved Agricultural Community
批准号:
10428025
负责人:
Jacqueline Marie Torres
金额:
$8.66万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-09-15 至 2025-05-31
关键词:
AchievementAdultAgingAgricultureAlzheimer disease preventionAlzheimer&aposs disease related dementiaAmericanAreaAwarenessBiological MarkersBrainCaliforniaChildCholesterolChronic DiseaseCognition DisordersCognitiveColorCommunitiesDementiaDevelopmentDiabetes MellitusDisadvantagedDiseaseEarly InterventionElderlyEnvironmental Risk FactorFamilyFeelingFocus GroupsFriendsFundingGoalsGrantHealthHypertensionIndividualInflammationInflammatoryInterventionInterviewKnowledgeLatinaLatinoLeadLifeLife Cycle StagesLife StyleLow incomeMagnetic Resonance ImagingMeasuresMediatingMedicalMedical ResearchMental DepressionMexicanMexican AmericansMexicoModelingMorbidity - disease rateMothersMotivationNon-Insulin-Dependent Diabetes MellitusObesityOutcomePF4 GeneParticipantPathologyPerceptionPopulationPredispositionPrevalencePreventionPrevention ResearchPrevention strategyPreventivePsychological FactorsResearchResearch Project GrantsRiskRisk FactorsRuralSamplingSmokingSpiritualityStressStrokeStructureTimeWomanagedaging in placeaging populationagricultural communityagricultural pesticidebiopsychosocialbrain healthcardiometabolic riskcardiometabolismcardiovascular risk factorcognitive performancecohortdementia riskexperiencefunctional disabilityhealth assessmenthealth beliefmiddle agemild cognitive impairmentmodifiable riskmortalityparent grantpesticide exposurephysical inactivitypreventive interventionrecruitresidencerural areasocialsocial factorstheorieswhite matter
中文摘要
基金资助或项目的摘要或摘要。
英文摘要
Summary or abstract of the funded grant or project.
The parent grant project aims to understand the unique and combined impacts of social and environmental
factors on ADRDs risk and relevant mechanisms. We propose to leverage a well-established cohort from The
Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study of approximately 550
Latina women who are entering mid-life (mean = 47 years old). To study the associations between social
adversity, pesticide exposures, and ADRDs risk among Latinos, our Specific Aims are:
1. To quantify associations between early and mid-life social adversity and cognitive performance
among mid-life Latina women and the extent to which these associations are explained by
cardiometabolic and inflammatory mechanisms. Informed by the life course perspective, we
hypothesize that early and mid-life adversity will each independently contribute to poorer cognitive
outcomes, but that women who experience both will be most cognitive disadvantaged in mid-life. We also
expect that cardio-metabolic risk factors and inflammation will partially mediate any observed
associations.
2. To estimate associations between agricultural pesticide exposure and cognitive performance and
to evaluate whether social adversity and pesticide exposure interact to produce poorer cognitive
outcomes among mid-life Latina women. We hypothesize that pesticide exposure, evaluated via both
area- level metrics and individual biomarkers, will adversely impact mid-life cognitive outcomes. Informed
by an exposure-stress-disease framework, we further hypothesize that pesticide exposure and social
adversity will combine to produce poorer cognitive outcomes.
3. To evaluate relationships between life course social adversity, pesticide exposure, and brain
biomarkers among mid-life Latina women. We will measure total brain and regional volume and white
matter hyper-intensities via magnetic resonance imaging (MRI) on a subset of 200 women. In exploratory
analyses, we will also evaluate whether social adversity and/or pesticide exposure modify associations
between brain structure, pathology, and cognitive performance.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The contribution of adult child socio-economic status to parents' risk and outcomes of Alzheimer's disease and related dementias (ADRDs) in cross-national settings
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批准号:10361136
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项目类别:
-
资助金额:$74.31万
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财政年份:2022
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负责人:Jacqueline Marie Torres
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依托单位:
The contribution of adult child socio-economic status to parents' risk and outcomes of Alzheimer's disease and related dementias (ADRDs) in cross-national settings
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批准号:10554276
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项目类别:
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资助金额:$73.42万
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财政年份:2022
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负责人:Jacqueline Marie Torres
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依托单位:
Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural region
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批准号:10261507
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项目类别:
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资助金额:$198.01万
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财政年份:2020
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负责人:Jacqueline Marie Torres
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依托单位:
Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural region
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批准号:10054668
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项目类别:
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资助金额:$123.87万
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财政年份:2020
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负责人:Jacqueline Marie Torres
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依托单位:
Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural region
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批准号:10412115
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项目类别:
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资助金额:$190.32万
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财政年份:2020
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负责人:Jacqueline Marie Torres
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依托单位:
Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural region
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批准号:10517435
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项目类别:
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资助金额:$11.55万
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财政年份:2020
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负责人:Jacqueline Marie Torres
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依托单位:
Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural region
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批准号:10633276
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项目类别:
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资助金额:$154.19万
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财政年份:2020
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负责人:Jacqueline Marie Torres
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依托单位:
A cross-national perspective on social integration and cognitive aging for Mexican-origin adults in the U.S. and Mexico: Quantifying the effects of both local and cross-border social integration
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批准号:9921278
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项目类别:
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资助金额:$13.04万
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财政年份:2017
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负责人:Jacqueline Marie Torres
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依托单位:
A cross-national perspective on social integration and cognitive aging for Mexican-origin adults in the U.S. and Mexico: Quantifying the effects of both local and cross-border social integration
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批准号:9370432
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项目类别:
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资助金额:$13.04万
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财政年份:2017
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负责人:Jacqueline Marie Torres
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依托单位:
A Comparison of Mental Health for Mexican and Mexican American Older Adults
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批准号:8397312
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项目类别:
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资助金额:$3.38万
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财政年份:2012
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负责人:Jacqueline Marie Torres
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依托单位:
A Comparison of Mental Health for Mexican and Mexican American Older Adults
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批准号:8521028
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项目类别:
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资助金额:$3.09万
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财政年份:2012
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负责人:Jacqueline Marie Torres
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依托单位:
海外基金