Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
基本信息
- 批准号:10430134
- 负责人:
- 金额:$ 172.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescenceAdolescentAffectAffectiveAgeAmygdaloid structureBehaviorBehavioralCellular PhoneChildCognitionCognitiveCorpus striatum structureCross-Sectional StudiesCuesDevelopmentDevelopmental ProcessDorsalEmotionalEmotionsEtiologyExposure toFemaleFrequenciesGoalsGrainIndividualInstitutionalizationInterventionKnowledgeLeadLife Cycle StagesLinkLongitudinal StudiesMapsMeasuresMediatingMental HealthMental disordersMethodologyMethodsMonitorNegative ValenceNeurophysiology - biologic functionOnset of illnessParietalPatternPerformancePhenotypePhysical activityPositive ValencePreventionProcessPsychopathologyResearchResearch Domain CriteriaRestRewardsRiskShapesSocial BehaviorSocial ProcessesSpecificityStressStressful EventSymptomsSystemTechnologyTelephoneTextTheoretical modelTimeVariantVentral StriatumViolenceWorkYouthabuse neglectcognitive controlcohortdesigndigitalemotional stimulusexperienceimprovedinnovationlongitudinal designnegative affectneural circuitneuromechanismnovelnovel strategiespeerpreventprospectiverelating to nervous systemresponsesexsleep behaviorsleep qualitysleep quantitysocialsocial engagementsocial mediawearable device
项目摘要
PROJECT SUMMARY
Exposure to stressful life events (SLEs) is involved in the etiology of most forms of psychopathology, and SLEs
occurring early in development are particularly strong predictors of mental health problems. Most adolescent
disorder onsets are temporally preceded by a major SLE. Yet, the mechanisms linking SLEs to the onset of
adolescent psychopathology remain poorly understood. Prior research on mechanisms linking SLEs with youth
mental disorders has focused largely on severe forms of adversity like abuse, neglect, and institutionalization.
It is unknown whether similar mechanisms are involved in the link between less severe SLEs and
psychopathology. Perhaps more critically, existing work has relied largely on cross-sectional between-subjects
designs that compare children with exposure to some type of SLE to children without that experience. There is
a dearth of longitudinal studies examining how SLEs influence emotion, cognition, behavior, and neural circuits
within-individuals over time in ways that predict the emergence of psychopathology. The proposed research
addresses this gap, using a novel methodological approach that permits examination of dynamic changes in
emotion, cognition, social behavior, and neural function and connectivity following SLEs at a sufficiently fine
grained level of temporal specificity to identify mechanisms underlying the link between SLEs and adolescent
psychopathology as they unfold in real time. Specifically, the project will examine how monthly fluctuations in
exposure to SLEs within-individuals predict subsequent changes in emotional processing in the Negative and
Positive Valence Systems, Cognitive Control, Social Processes, and neural function and connectivity over a
12-month period. In addition to monthly assessments of SLEs, psychopathology, and potential mechanisms,
passive monitoring of activity, sleep, and social behavior (e.g., interaction with peers through text and social
media) through smartphones and wearable devices will allow additional mechanisms to be assessed passively
and without subject burden. The study will investigate whether monthly variation in these emotional, cognitive,
social, and neural processes predicts later increases in internalizing and externalizing problems in an
accelerated cohort design with monthly assessments spanning age 11-18 years, producing 1,680 monthly
observations over the study period. The longitudinal design and high-frequency assessments are innovative
in allowing the identification of mechanisms that are altered by SLEs and prospectively predict
psychopathology with high temporal specificity during a developmental period associated with increases in
SLE exposure, stress vulnerability, and risk for psychopathology. Study findings will provide critical information
regarding the specific domains of emotion, cognition, social behavior, and neural function that are altered by
exposure to SLEs and increase vulnerability to psychopathology. These mechanisms represent modifiable
targets for interventions to prevent the onset of stress-related psychopathology in children and adolescents.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Katie McLaughlin其他文献
Katie McLaughlin的其他文献
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{{ truncateString('Katie McLaughlin', 18)}}的其他基金
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
- 批准号:
10162663 - 财政年份:2020
- 资助金额:
$ 172.72万 - 项目类别:
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
- 批准号:
9885491 - 财政年份:2020
- 资助金额:
$ 172.72万 - 项目类别:
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
- 批准号:
10887678 - 财政年份:2020
- 资助金额:
$ 172.72万 - 项目类别:
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
- 批准号:
10599696 - 财政年份:2020
- 资助金额:
$ 172.72万 - 项目类别:
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
- 批准号:
10768363 - 财政年份:2020
- 资助金额:
$ 172.72万 - 项目类别:
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
- 批准号:
10687187 - 财政年份:2020
- 资助金额:
$ 172.72万 - 项目类别:
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence
青春期压力脆弱性背后的神经发育机制
- 批准号:
9906554 - 财政年份:2019
- 资助金额:
$ 172.72万 - 项目类别:
Deprivation and Threat: Dimensions of Early Experience and Neural Development
剥夺和威胁:早期经历和神经发育的维度
- 批准号:
9895868 - 财政年份:2018
- 资助金额:
$ 172.72万 - 项目类别:
Deprivation and Threat: Dimensions of Early Experience and Neural Development
剥夺和威胁:早期经历和神经发育的维度
- 批准号:
9190327 - 财政年份:2015
- 资助金额:
$ 172.72万 - 项目类别:
Deprivation and Threat: Dimensions of Early Experience and Neural Development
剥夺和威胁:早期经历和神经发育的维度
- 批准号:
9027478 - 财政年份:2015
- 资助金额:
$ 172.72万 - 项目类别:
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