OGT as a dosage sensor
OGT as a dosage sensor
批准号:
10440360
负责人:
ALMA L BURLINGAME
金额:
$41.59万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-15 至 2024-06-30
关键词:
Active SitesAffectAllelesBindingCell CountCellsChromatinChromatin Remodeling FactorComplexCuesCytoplasmic ProteinCytosineDNADNA MethylationDNA Modification MethylasesDataDevelopmentDioxygenasesDiploidyDosage Compensation (Genetics)DoseEmbryoEnsureEnzymesEpigenetic ProcessExhibitsFailureFemaleFutureGene DosageGene ExpressionGenesGenetic TranscriptionInner Cell MassLinkMammalsMediatingMessenger RNAMitochondrial ProteinsModelingModificationMolecularMutationNuclearNuclear ProteinsOxidesPeptidesPost-Translational Protein ProcessingProductionProteinsRNARegulationRoleSignal PathwaySystemTestingTranscriptTransferaseUntranslated RNAUp-RegulationX ChromosomeX InactivationXY femalesdemethylationdosageembryonic stem cellflyin vivoinsightlink proteinmalemethyl groupmutantoxidationpromoterprotein expressionrecruitresponsesensorstoichiometrysugartranscription factorvirtual
中文摘要
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英文摘要
Project Summary
Epigenetic regulators often lie downstream of signaling pathways that culminate in post-translational
modifications, which affect their activity and ensure appropriate transcriptional responses to developmental and
environmental cues. Our preliminary studies indicate that an interaction between epigenetic regulator, TET3,
and an X-linked, post-translational modification enzyme, OGT, may be central in detecting X chromosome
dosage and poising cells for X-inactivation. We propose to investigate the role of the TET3-OGT interaction in
regulation of X chromosome inactivation, to obtain molecular insight into how cells count X chromosomes.
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OGT as a dosage sensor
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批准号:10200841
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项目类别:
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资助金额:$41.59万
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财政年份:2019
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负责人:ALMA L BURLINGAME
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依托单位:
Purchase of Q-Exactive Mass Spectrometer
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批准号:8447398
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项目类别:
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资助金额:$50.69万
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财政年份:2013
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负责人:ALMA L BURLINGAME
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依托单位:
UTILIZATION OF QSTARXL MASS SPECTROMETER, LC SYSTEM & ASSOCIATED SOFTWARE
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批准号:8363759
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项目类别:
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资助金额:$1.72万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
STRUCTURAL ANALYSIS OF SCORPION VENOM VAEJOVIS MEXICANUS SMITHI
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批准号:8363774
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项目类别:
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资助金额:$0.01万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
OPTIMIZATION OF ETD TECHNIQUE ON THE LTQ ORBITRAP
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批准号:8363798
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项目类别:
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资助金额:$1.1万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
CHARACTERIZATION OF THE EARLY APOPTOTIC MITOCHONDRIAL PROTEOME
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批准号:8363803
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项目类别:
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资助金额:$0.01万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
DECIPHERING THE PHOSPHOPROTEOME OF T LYMPHOCYTES
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批准号:8363775
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项目类别:
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资助金额:$0.13万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
VISUALIZATION OF QUANTITATIVE BIOLOGICAL MASS SPECTROMETRY DATA
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批准号:8363629
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项目类别:
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资助金额:$1.01万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
ONGOING FEASIBILITY STUDIES
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批准号:8363728
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项目类别:
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资助金额:$13.55万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
UTILIZATION OF QSTAR MASS SPECTROMETERS, LC SYSTEM & ASSOCIATED SOFTWARE
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批准号:8363742
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项目类别:
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资助金额:$4.01万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
UTILIZATION OF THERMOELECTRON LTQ MASS SPECTROMETER AND ASSOCIATED SOFTWARE
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批准号:8363760
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项目类别:
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资助金额:$2.86万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
SEPARATION OF HISTONES & CHARC OF INTACT PROTEINS &MODIFICATIONS BY MASS SPEC
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批准号:8363765
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项目类别:
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资助金额:$0.0万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
TOWARD AN OPTIMIZED PROTEIN-PROTEIN CROSS-LINKING STRATEGY FOR PROTEIN COMPLEXES
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批准号:8363770
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项目类别:
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资助金额:$1.67万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
CHARACTERIZATION OF STRUCTURE AND FUNCTION OF HISTONES IN EMBRYONIC STEM CELLS
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批准号:8363784
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项目类别:
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资助金额:$0.0万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
UTILIZATION & OPTIMIZATION OF APPLIED BIOSYSTEMS MALDI TOF TOF AND ASSOCIATED
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批准号:8363743
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项目类别:
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资助金额:$0.72万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
GLUTAMATE RECEPTOR COMPLEXES IN THE CENTRAL NERVOUS SYSTEM
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批准号:8363753
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项目类别:
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资助金额:$6.17万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
O-GLCNAC IN EMBRYONIC STEM CELLS
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批准号:8363810
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项目类别:
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资助金额:$1.95万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
CHARACTERIZATION OF HUMAN HISTONES WITH COMPLEX PTMS BY ECD
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批准号:8363779
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项目类别:
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资助金额:$3.78万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
LC TESTING AND PERFORMANCE OF MS INSTRUMENTATION
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批准号:8363727
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项目类别:
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资助金额:$13.17万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
DISSEMINATION OF BIOLOGICAL MS TECHNOLOGY & APPLICATIONS AT SCIENTIFIC MEETINGS
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批准号:8363741
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项目类别:
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资助金额:$11.98万
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财政年份:2011
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负责人:ALMA L BURLINGAME
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依托单位:
海外基金