Center for Excellence in Diabetes and Obesity Research

摘要 此应用程序用于支持科布雷支持的糖尿病和肥胖中心的第三阶段，地址为 路易斯维尔大学。该中心成立于2008年，中心目标是 支持分子、细胞、实验、翻译和临床研究 糖尿病和肥胖症的心血管原因和后果。在第一和第二阶段， 中心经历了惊人的增长。它促进了青少年的职业发展 研究人员，为糖尿病、肥胖症和 心血管研究，并为研究生和 博士后研究员。第三阶段的目标是为中心提供可持续的核心支持 研究人员并加强该机构的糖尿病和肥胖症研究；保持和 增强最先进的基础设施，促进研究并支持基础和翻译 在该中心的专题重点范围内进行研究。在第三阶段，该中心将支持5个核心- 核心A：行政核心，核心B：流式细胞术核心，核心C，病理学和生物分析 核心，核心D：动物模型和表型核心，核心E：成像和生理核心。 该中心还将支持一项试点项目计划，通过提供种子来刺激新的研究 为可能获得额外资金的有希望的项目提供资金。该中心提供独一无二的 心血管代谢、炎症和其他领域的研究机会 心脏代谢疾病、干细胞生物学和心脏代谢的环境决定因素 疾病。路易斯维尔大学一个充满活力、自给自足的糖尿病和肥胖中心 不仅为糖尿病、肥胖症领域的创新研究提供肥沃的土壤， 心血管研究，但它将使该机构成为一个持久的学习中心， 指导、培训和培养卓越的学术成就。

ABSTRACT This application is to support Phase III of the COBRE-supported Diabetes and Obesity Center at the University of Louisville. The Center was established in 2008, with the central objective of supporting molecular, cellular, experimental, translational and clinical investigations into the cardiovascular causes and consequences of diabetes and obesity. During Phase I and II, the Center underwent phenomenal growth. It has facilitated the career development of junior investigators, provided core support to investigators involved in diabetes, obesity and cardiovascular research, and has provided training and mentorship to graduate students and post-doctoral fellows. The goal in Phase III is to provide sustainable core support to Center investigators and strengthen diabetes and obesity research at the institution; to maintain and enhance state-of-the-art infrastructure, foster research and support basic and translational research within the thematic focus of the Center. In Phase III, the Center will support 5 Cores – Core A: An Administrative Core, Core B: Flow Cytometry Core, Core C, Pathology and Bioanlytics Core, Core D: Animal Models and Phenotyping Core, and Core E: Imaging and Physiology Core. The Center will also support a Pilot Project Program to stimulate new research by providing seed funding to promising projects that could obtain extramular funding. The Center provides unique opportunities for research in the areas of cardiovascular metabolism, inflammation and cardiometabolic disease, stem cell biology, and environmental determinants of cardiometabolic disease. A dynamic, self-sustaining Diabetes and Obesity Center at the University of Louisville will not only provide fertile ground for innovative studies in the area of diabetes, obesity, and cardiovascular research, but it will enable the institution to become an enduring hub of learning, mentoring, training, and fostering academic excellence.