Center for Excellence in Diabetes and Obesity Research

摘要 此应用程序是为了支持COBRE-supported糖尿病和肥胖中心的第三阶段， 路易斯维尔大学该中心成立于2008年，中心目标是 支持分子、细胞、实验、转化和临床研究， 糖尿病和肥胖的心血管原因和后果。在第一和第二阶段， 中心经历了惊人的增长。它促进了初级职业发展， 研究人员，为参与糖尿病，肥胖和 心血管研究，并为研究生提供培训和指导， 博士后研究员。第三阶段的目标是为中心提供可持续的核心支持。 研究人员和加强糖尿病和肥胖症的研究在该机构;保持和 加强最先进的基础设施，促进研究，支持基础和转化 研究中心的主题重点。在第三阶段，该中心将支持5个核心- 核心A：管理核心，核心B：流式细胞术核心，核心C，病理学和生物分析学 核心，核心D：动物模型和表型核心，以及核心E：成像和生理学核心。 该中心还将支持试点项目计划，通过提供种子来刺激新的研究。 资助有希望获得额外资助的项目。该中心提供独特的 在心血管代谢，炎症和 心脏代谢疾病、干细胞生物学和心脏代谢疾病的环境决定因素 疾病路易斯维尔大学的一个充满活力、自我维持的糖尿病和肥胖中心 不仅将为糖尿病、肥胖症和肥胖症领域的创新研究提供肥沃的土壤， 心血管研究，但它将使该机构成为一个持久的学习中心， 指导、培训和培养学术卓越。

ABSTRACT This application is to support Phase III of the COBRE-supported Diabetes and Obesity Center at the University of Louisville. The Center was established in 2008, with the central objective of supporting molecular, cellular, experimental, translational and clinical investigations into the cardiovascular causes and consequences of diabetes and obesity. During Phase I and II, the Center underwent phenomenal growth. It has facilitated the career development of junior investigators, provided core support to investigators involved in diabetes, obesity and cardiovascular research, and has provided training and mentorship to graduate students and post-doctoral fellows. The goal in Phase III is to provide sustainable core support to Center investigators and strengthen diabetes and obesity research at the institution; to maintain and enhance state-of-the-art infrastructure, foster research and support basic and translational research within the thematic focus of the Center. In Phase III, the Center will support 5 Cores – Core A: An Administrative Core, Core B: Flow Cytometry Core, Core C, Pathology and Bioanlytics Core, Core D: Animal Models and Phenotyping Core, and Core E: Imaging and Physiology Core. The Center will also support a Pilot Project Program to stimulate new research by providing seed funding to promising projects that could obtain extramular funding. The Center provides unique opportunities for research in the areas of cardiovascular metabolism, inflammation and cardiometabolic disease, stem cell biology, and environmental determinants of cardiometabolic disease. A dynamic, self-sustaining Diabetes and Obesity Center at the University of Louisville will not only provide fertile ground for innovative studies in the area of diabetes, obesity, and cardiovascular research, but it will enable the institution to become an enduring hub of learning, mentoring, training, and fostering academic excellence.