CENTER OF EXCELLENCE IN DIABETES AND OBESITY RESEARCH: CORE C

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心血管病理学核心是一个中心资源，用于生成和评估心血管疾病体内小鼠模型的数据，特别是那些合并糖尿病的疾病。这个核心在完好的小鼠身上进行外科阻断和再灌流。这些受试者可以通过超声心动图在核心D中随着时间的推移进行评估，组织可以通过几乎所有其他核心和单个项目来获取和评估。这一核心在活体小鼠脑梗塞模型方面有十多年的经验。事实证明，这种经验对科布雷每个项目的新调查人员来说都是无价的。除了心血管疾病的活体模型外，该核心还服务于单个项目的基本组织病理学需求。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Cardiovascular Pathology Core serves as a central resource for generating and evaluating data from in vivo mouse models of cardiovascular disease, particularly those that are complicated by diabetes. This Core performs surgical occlusion and reperfusion in the intact mouse. Such subjects can be evaluated over time in Core D via echocardiography and tissue can be harvested and evaluated by virtually all of the other Cores and individual Projects. This Core has more than a decade of experience in the in vivo mouse infarction model. Such experience will prove invaluable for the new investigators in each of the COBRE's Projects. In addition to the in vivo models of cardiovascular disease, this Core serves the basic histopathology needs of the individual projects.