Imaging and Physiology Core

影像和生理学核心

• 批准号: 10208903
• 负责人: Steven P Jones
• 金额: $ 20.25万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208903
• 关键词: Address; Affect; Area; Attention; Businesses; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cells; Centers of Research Excellence; Charge; Collaborations; Communication; Communities; Complications of Diabetes Mellitus; Counseling; Data Analyses; Development; Diabetes Mellitus; Disease model; Echocardiography; Education; Effectiveness; Ensure; Extramural Activities; Faculty; Felis catus; Fruit; Funding; Future; Goals; Grant; Growth; Health; Human Resources; Image; Individual; Infrastructure; Instruction; Investigation; Investments; Mentors; Mentorship; Microscopy; Mission; Modeling; Monitor; Mus; Obesity; Operative Surgical Procedures; Phase; Physiology; Policies; Procedures; Protocols documentation; Publications; Research; Research Design; Research Personnel; Resources; Role; Services; Surgical Models; Techniques; Tissue imaging; Training; Training and Education; United States National Institutes of Health; Universities; Work; cardiometabolism; confocal imaging; consumer product; flexibility; fluorescence imaging; heart function; imaging approach; imaging modality; improved; in vivo imaging; innovation; instrumentation; investigator training; meetings; member; non-invasive imaging; protocol development; sound; success; technological innovation; theories

The Imaging and Physiology Core (Core E) will nurture the Center’s continued growth and hasten project development by promoting scientific excellence in investigations of cardiometabolic diseases. Core E will anticipate the needs of the Center’s investigators—particularly junior investigators, whose collective needs change—by maintaining uninterrupted communication with Center members regarding their projects’ directions. Core E will provide access to state-of-the-art instrumentation and deliver expert instruction related to non- invasive imaging, murine surgical models, and advanced microscopy. The Core will promote education on the theory and technical appreciation of relevant approaches, instrumentation, and techniques. The Core will collaborate with Center members, particularly junior investigators, to develop new, tailored procedures to answer their experimental questions. The Director will provide guidance not only for the techniques provided by Core E, but also mentorship to the junior faculty members in the Center. In addition to meeting the needs of the Center’s projects, the Core has established a viable plan to transition to financial independence during Phase III of COBRE support. These collective aspirational goals will be accomplished through the following Aims: i) Support Center projects through excellence in imaging and physiology; ii) Become a self-sustaining feature of the Center by cultivating the Core’s financial independence; iii) Develop new protocols and techniques for future imaging and physiology needs of the Center; iv) Educate and train investigators on the theory, application, and analyses related to imaging and physiology. Support during Phases I and II of COBRE, the University, the Center, and faculty members have contributed significantly to the extensive instrumentation in Core E. Such investments reflect the important role of Core E in the progress of the Center. The Director will continue developing new protocols, acquiring the latest instrumentation, and initiating collaborations with additional investigators throughout the campus community. The Core will make every effort to meet the imaging and physiology needs of all of the Center members while leveraging complementary resources on campus. This Core will maintain its current excellent level of service and actively seek to improve its infrastructure while provide the Center members with state-of-the-art instrumentation. Such progress will continue with the long-term goal of establishing a self- sustaining Core. As Core E moves into Phase III, the Core will formally engage its business model to bring its plan for self-sufficiency to fruition. Core E will work closely with Core A to maintain its financial goals, to ensure its effectiveness, and to enhance its efficiency. Furthermore, this Core will be pivotal in bringing this Center to national prominence in cardiometabolic research. The results of such efforts have been, and will continue to be, evident in the Center’s COBRE graduates, numerous publications, and growth in NIH funding of Core-supported Center members. Core E will remain a bedrock of technological development, scientific innovation, and relevant training for the Center as it tackles the greatest threats to health: diabetes and cardiovascular disease.

成像和生理核心（核心E）将护理该中心的持续增长和促进项目 通过促进心脏代谢疾病调查的科学卓越发展来发展。核心E 预期该中心调查人员的需求 - 尤其是初级调查人员，他们的集体需求 改变 - 通过与中心成员有关项目的指示保持不间断的沟通。 核心E将提供对最新仪器的访问，并提供与非 - 侵入性成像，鼠手术模型和晚期显微镜。核心将促进教育 相关方法，仪器和技术的理论和技术欣赏。核心意愿 与中心成员，特别是初级调查人员合作，以开发新的，量身定制的程序来回答 他们的实验问题。主任将不仅为核心E提供的技术提供指导 但也要对中心的初级教职员工进行心态。除了满足中心的需求 项目，核心已经制定了一项可行的计划，可以在第三阶段过渡到财务独立性 毛绒支撑。这些集体的抱负目标将通过以下目的实现：i）支持 通过卓越的成像和生理学项目中心项目； ii）成为中心的自我维持功能 通过培养核心的财务独立性； iii）为未来成像开发新的协议和技术 中心的生理需求； iv）教育和培训研究人员就理论，应用和分析进行教育 与成像和生理学有关。在Cobre，University，Center和 教职员工为核心E的广泛工具做出了重大贡献。 反映了核心E在中心进步中的重要作用。董事将继续开发新的 协议，获取最新工具，并与其他调查人员合作 在整个校园社区。核心将尽一切努力满足成像和生理需求 在所有中心成员的同时，在校园里利用互补资源的同时。这个核心将保持其 当前的出色服务水平，并积极寻求改善其基础设施，同时为中心成员提供 带有最先进的仪器。这种进步将继续以建立自我的长期目标继续 维持核心。随着核心E进入第三阶段，核心将正式参与其业务模型以实现其 计划自给自足。核心E将与核心A紧密合作，以维护其财务目标，以确保 它的有效性，并提高其效率。此外，这个核心将在将这个中心带到 心脏代谢研究的国家突出。这种努力的结果已经并且将继续是 该中心的索伯毕业生，众多出版物和NIH资助的核心支持的证据 中心成员。核心E将仍然是技术发展，科学创新和相关的基石 该中心的培训应对健康的最大威胁：糖尿病和心血管疾病。