Imaging and Physiology Core

影像和生理学核心

• 批准号: 10208903
• 负责人: Steven P Jones
• 金额: $ 20.25万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208903
• 关键词: Address; Affect; Area; Attention; Businesses; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cells; Centers of Research Excellence; Charge; Collaborations; Communication; Communities; Complications of Diabetes Mellitus; Counseling; Data Analyses; Development; Diabetes Mellitus; Disease model; Echocardiography; Education; Effectiveness; Ensure; Extramural Activities; Faculty; Felis catus; Fruit; Funding; Future; Goals; Grant; Growth; Health; Human Resources; Image; Individual; Infrastructure; Instruction; Investigation; Investments; Mentors; Mentorship; Microscopy; Mission; Modeling; Monitor; Mus; Obesity; Operative Surgical Procedures; Phase; Physiology; Policies; Procedures; Protocols documentation; Publications; Research; Research Design; Research Personnel; Resources; Role; Services; Surgical Models; Techniques; Tissue imaging; Training; Training and Education; United States National Institutes of Health; Universities; Work; cardiometabolism; confocal imaging; consumer product; flexibility; fluorescence imaging; heart function; imaging approach; imaging modality; improved; in vivo imaging; innovation; instrumentation; investigator training; meetings; member; non-invasive imaging; protocol development; sound; success; technological innovation; theories

The Imaging and Physiology Core (Core E) will nurture the Center’s continued growth and hasten project development by promoting scientific excellence in investigations of cardiometabolic diseases. Core E will anticipate the needs of the Center’s investigators—particularly junior investigators, whose collective needs change—by maintaining uninterrupted communication with Center members regarding their projects’ directions. Core E will provide access to state-of-the-art instrumentation and deliver expert instruction related to non- invasive imaging, murine surgical models, and advanced microscopy. The Core will promote education on the theory and technical appreciation of relevant approaches, instrumentation, and techniques. The Core will collaborate with Center members, particularly junior investigators, to develop new, tailored procedures to answer their experimental questions. The Director will provide guidance not only for the techniques provided by Core E, but also mentorship to the junior faculty members in the Center. In addition to meeting the needs of the Center’s projects, the Core has established a viable plan to transition to financial independence during Phase III of COBRE support. These collective aspirational goals will be accomplished through the following Aims: i) Support Center projects through excellence in imaging and physiology; ii) Become a self-sustaining feature of the Center by cultivating the Core’s financial independence; iii) Develop new protocols and techniques for future imaging and physiology needs of the Center; iv) Educate and train investigators on the theory, application, and analyses related to imaging and physiology. Support during Phases I and II of COBRE, the University, the Center, and faculty members have contributed significantly to the extensive instrumentation in Core E. Such investments reflect the important role of Core E in the progress of the Center. The Director will continue developing new protocols, acquiring the latest instrumentation, and initiating collaborations with additional investigators throughout the campus community. The Core will make every effort to meet the imaging and physiology needs of all of the Center members while leveraging complementary resources on campus. This Core will maintain its current excellent level of service and actively seek to improve its infrastructure while provide the Center members with state-of-the-art instrumentation. Such progress will continue with the long-term goal of establishing a self- sustaining Core. As Core E moves into Phase III, the Core will formally engage its business model to bring its plan for self-sufficiency to fruition. Core E will work closely with Core A to maintain its financial goals, to ensure its effectiveness, and to enhance its efficiency. Furthermore, this Core will be pivotal in bringing this Center to national prominence in cardiometabolic research. The results of such efforts have been, and will continue to be, evident in the Center’s COBRE graduates, numerous publications, and growth in NIH funding of Core-supported Center members. Core E will remain a bedrock of technological development, scientific innovation, and relevant training for the Center as it tackles the greatest threats to health: diabetes and cardiovascular disease.

成像和生理学核心（核心E）将培育中心的持续增长和加速项目 通过促进心脏代谢疾病研究方面的科学卓越性，促进发展。核心E将 预测该中心的调查员的需求，特别是初级调查员，他们的集体需求 改变-通过与中心成员就其项目方向保持不间断的沟通。 核心E将提供访问国家的最先进的仪器，并提供专家指导有关的非 侵入性成像、鼠手术模型和先进显微镜。核心小组将促进教育， 相关方法、仪器和技术的理论和技术评价。芯会 与中心成员，特别是初级研究人员合作，制定新的、量身定制的程序， 他们的实验问题。主任不仅将为核心E提供的技术提供指导， 同时也为中心的年轻教师提供指导。除了满足中心的需求外， 核心项目已制定了一项可行的计划，在第三阶段过渡到财务独立， COBRE支援这些共同的理想目标将通过以下目标来实现： 中心通过卓越的成像和生理学开展项目; ii）成为中心的自我维持功能 通过培养核心的财务独立性; iii）为未来的成像开发新的协议和技术 四）教育和培训研究人员的理论，应用和分析 与成像和生理学有关。在COBRE第一和第二阶段，大学，中心和 教师们为核心E的广泛仪器做出了重大贡献。此类投资 反映了核心E在中心发展中的重要作用。主任将继续开发新的 协议，获取最新的仪器，并启动与其他研究者的合作 整个校园社区。核心将尽一切努力满足成像和生理需求 所有的中心成员，同时利用校园互补资源。这一核心将保持其 目前卓越的服务水平，并积极寻求改善其基础设施，同时提供中心成员 用最先进的仪器这一进展将随着建立一个自我的长期目标而继续下去， 维持核心。随着Core E进入第三阶段，Core将正式采用其商业模式， 实现自给自足的计划核心E将与核心A密切合作，以维持其财务目标， 其效力，并提高其效率。此外，这一核心将是关键，使该中心， 在心脏代谢研究中的国家突出地位。这些努力的结果已经并将继续是， 在该中心的COBRE毕业生，众多的出版物，以及NIH资助的核心支持的增长中， 中心成员。核心E仍将是技术发展、科学创新和相关技术的基石。 该中心致力于解决对健康的最大威胁：糖尿病和心血管疾病。