CENTER OF EXCELLENCE IN DIABETES AND OBESITY RESEARCH: CORE C

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 心血管病理学核心是一个中心资源，用于生成和评估心血管疾病体内小鼠模型的数据，特别是那些并发糖尿病的数据。 该核心在完整小鼠中进行手术闭塞和再灌注。 这些受试者可以通过超声心动图在核心D中随时间进行评价，几乎所有其他核心和单个项目都可以采集和评价组织。 该Core在体内小鼠梗死模型方面拥有十多年的经验。 这些经验对于COBRE每个项目的新调查员来说都是非常宝贵的。 除了心血管疾病的体内模型外，该核心还满足各个项目的基本组织病理学需求。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Cardiovascular Pathology Core serves as a central resource for generating and evaluating data from in vivo mouse models of cardiovascular disease, particularly those that are complicated by diabetes. This Core performs surgical occlusion and reperfusion in the intact mouse. Such subjects can be evaluated over time in Core D via echocardiography and tissue can be harvested and evaluated by virtually all of the other Cores and individual Projects. This Core has more than a decade of experience in the in vivo mouse infarction model. Such experience will prove invaluable for the new investigators in each of the COBRE's Projects. In addition to the in vivo models of cardiovascular disease, this Core serves the basic histopathology needs of the individual projects.