CENTER OF EXCELLENCE IN DIABETES AND OBESITY RESEARCH: CORE C

糖尿病和肥胖研究卓越中心：CORE C

• 批准号: 8360411
• 负责人: Steven P Jones
• 金额: $ 10.96万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360411
• 关键词: Cardiovascular Diseases; Cardiovascular Pathology; Data; Diabetes Mellitus; Echocardiography; Funding; Grant; Harvest; Histopathology; Individual; Infarction; Modeling; Mus; National Center for Research Resources; Obesity; Operative Surgical Procedures; Principal Investigator; Reperfusion Therapy; Research; Research Infrastructure; Research Personnel; Resources; Source; Time; Tissues; United States National Institutes of Health; cost; experience; in vivo; in vivo Model; mouse model

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Cardiovascular Pathology Core serves as a central resource for generating and evaluating data from in vivo mouse models of cardiovascular disease, particularly those that are complicated by diabetes. This Core performs surgical occlusion and reperfusion in the intact mouse. Such subjects can be evaluated over time in Core D via echocardiography and tissue can be harvested and evaluated by virtually all of the other Cores and individual Projects. This Core has more than a decade of experience in the in vivo mouse infarction model. Such experience will prove invaluable for the new investigators in each of the COBRE's Projects. In addition to the in vivo models of cardiovascular disease, this Core serves the basic histopathology needs of the individual projects.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 心血管病理学核心是生成和评估心血管疾病体内小鼠模型数据的中心资源，特别是那些并发糖尿病的模型。 该核心对完整的小鼠进行手术闭塞和再灌注。 随着时间的推移，这些受试者可以通过超声心动图在核心 D 中进行评估，并且几乎所有其他核心和单个项目都可以采集和评估组织。 该Core在小鼠体内梗死模型方面拥有十多年的经验。 这些经验对于 COBRE 每个项目的新研究人员来说都是无价的。 除了心血管疾病的体内模型外，该核心还满足各个项目的基本组织病理学需求。