Imaging and Physiology Core

影像和生理学核心

• 批准号: 10452737
• 负责人: Steven P Jones
• 金额: $ 20.25万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452737
• 关键词: Address; Affect; Area; Attention; Businesses; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cells; Centers of Research Excellence; Charge; Collaborations; Communication; Communities; Complications of Diabetes Mellitus; Counseling; Data Analyses; Development; Diabetes Mellitus; Disease model; Echocardiography; Education; Effectiveness; Ensure; Extramural Activities; Faculty; Felis catus; Fruit; Funding; Future; Goals; Grant; Growth; Health; Human Resources; Image; Individual; Infrastructure; Instruction; Investigation; Investments; Mentors; Mentorship; Microscopy; Mission; Modeling; Monitor; Mus; Obesity; Operative Surgical Procedures; Phase; Physiology; Policies; Procedures; Protocols documentation; Publications; Research; Research Design; Research Personnel; Resources; Role; Services; Surgical Models; Techniques; Tissue imaging; Training; Training and Education; United States National Institutes of Health; Universities; Work; cardiometabolism; confocal imaging; consumer product; flexibility; fluorescence imaging; heart function; imaging approach; imaging modality; improved; in vivo imaging; innovation; instrumentation; investigator training; meetings; member; non-invasive imaging; protocol development; sound; success; technological innovation; theories

The Imaging and Physiology Core (Core E) will nurture the Center’s continued growth and hasten project development by promoting scientific excellence in investigations of cardiometabolic diseases. Core E will anticipate the needs of the Center’s investigators—particularly junior investigators, whose collective needs change—by maintaining uninterrupted communication with Center members regarding their projects’ directions. Core E will provide access to state-of-the-art instrumentation and deliver expert instruction related to non- invasive imaging, murine surgical models, and advanced microscopy. The Core will promote education on the theory and technical appreciation of relevant approaches, instrumentation, and techniques. The Core will collaborate with Center members, particularly junior investigators, to develop new, tailored procedures to answer their experimental questions. The Director will provide guidance not only for the techniques provided by Core E, but also mentorship to the junior faculty members in the Center. In addition to meeting the needs of the Center’s projects, the Core has established a viable plan to transition to financial independence during Phase III of COBRE support. These collective aspirational goals will be accomplished through the following Aims: i) Support Center projects through excellence in imaging and physiology; ii) Become a self-sustaining feature of the Center by cultivating the Core’s financial independence; iii) Develop new protocols and techniques for future imaging and physiology needs of the Center; iv) Educate and train investigators on the theory, application, and analyses related to imaging and physiology. Support during Phases I and II of COBRE, the University, the Center, and faculty members have contributed significantly to the extensive instrumentation in Core E. Such investments reflect the important role of Core E in the progress of the Center. The Director will continue developing new protocols, acquiring the latest instrumentation, and initiating collaborations with additional investigators throughout the campus community. The Core will make every effort to meet the imaging and physiology needs of all of the Center members while leveraging complementary resources on campus. This Core will maintain its current excellent level of service and actively seek to improve its infrastructure while provide the Center members with state-of-the-art instrumentation. Such progress will continue with the long-term goal of establishing a self- sustaining Core. As Core E moves into Phase III, the Core will formally engage its business model to bring its plan for self-sufficiency to fruition. Core E will work closely with Core A to maintain its financial goals, to ensure its effectiveness, and to enhance its efficiency. Furthermore, this Core will be pivotal in bringing this Center to national prominence in cardiometabolic research. The results of such efforts have been, and will continue to be, evident in the Center’s COBRE graduates, numerous publications, and growth in NIH funding of Core-supported Center members. Core E will remain a bedrock of technological development, scientific innovation, and relevant training for the Center as it tackles the greatest threats to health: diabetes and cardiovascular disease.

影像和生理学核心（核心 E）将促进该中心的持续发展并加快项目进程 通过促进心脏代谢疾病研究的科学卓越来发展。核心E将 预测中心调查人员的需求，特别是初级调查人员的集体需求 改变——通过与中心成员就其项目方向保持不间断的沟通。 Core E 将提供最先进的仪器，并提供与非相关的专家指导。 侵入性成像、小鼠手术模型和先进的显微镜。核心将促进有关教育 对相关方法、仪器和技术的理论和技术评价。核心将 与中心成员，特别是初级研究人员合作，开发新的、量身定制的程序来回答 他们的实验问题。总监不仅会为Core E提供的技术提供指导， 还为中心的初级教员提供指导。除了满足中心的需求外 项目，核心制定了可行的计划，以在第三阶段过渡到财务独立 COBRE 支持。这些集体理想目标将通过以下目标来实现： i) 支持 通过卓越的影像学和生理学中心项目； ii) 成为中心的一个自我维持的功能 通过培养核心的财务独立性； iii) 开发未来成像的新协议和技术 和中心的生理需求； iv) 对研究人员进行理论、应用和分析方面的教育和培训 与影像学和生理学相关。 COBRE、大学、中心和 COBRE 第一阶段和第二阶段期间的支持 教员们为 Core E 的广泛仪器做出了重大贡献。此类投资 体现了Core E在中心进步中的重要作用。导演将继续开发新的 协议，获取最新的仪器，并开始与其他研究人员合作 整个校园社区。 Core将竭尽全力满足影像和生理需求 所有中心成员的参与，同时利用校园内的互补资源。该核心将保持其 当前卓越的服务水平，并积极寻求改善其基础设施，同时为中心成员提供服务 配备最先进的仪器。随着建立自主知识产权的长期目标，这种进步将继续下去。 维持核心。随着Core E进入第三阶段，Core将正式采用其商业模式，以将其 自给自足的计划得以实现。核心 E 将与核心 A 密切合作以维持其财务目标，以确保 其有效性，并提高其效率。此外，该核心对于使该中心成为 在心脏代谢研究领域享有盛誉。这些努力的结果已经并将继续是： 该中心的 COBRE 毕业生、大量出版物以及 NIH 核心支持资金的增长都体现了这一点 中心成员。 Core E仍将是技术发展、科学创新和相关领域的基石。 为该中心提供培训，以解决对健康的最大威胁：糖尿病和心血管疾病。