Adipose Tissue: Energizing Good Fat

摘要 要求支持一次题为“脂肪组织：为好脂肪提供能量”的基石专题讨论会， 由Silvia Corvera、Kendra Bence和Rana Gupta博士组织。会议将在基斯通举行， 科罗拉多，2023年1月15日至19日。 脂肪组织在代谢健康中起着至关重要的作用。更好地了解它的生物学将指导 开发代谢性疾病的新疗法。因此，这次会议的目的是 解决该领域从生理到分子的关键新问题，以促进协同作用 同时也为新学员提供更好的关键知识差距的情况。 要涵盖的关键问题包括：不同的脂肪组织库如何有助于系统性 新陈代谢？有多少种类型的脂肪细胞存在，以及它们如何有助于不同的功能， 仓库？脂肪细胞是如何从祖细胞发育而来的？免疫细胞， 血管和神经支配影响其发育？最后，脂肪细胞的脂滴和 线粒体的发展，功能和影响全身代谢稳态？也会有讨论 关于如何展望与人类健康更广泛主题有关的脂肪组织研究。脂肪组织 功能障碍，表现为肥胖和代谢疾病， 在医学和研究领域代表性不足。因此，这种健康不平等将通过 主题演讲以及健康差距研讨会。该计划还将包括职业发展 为学员举办的讲习班。最后，本次会议将与Keystone研讨会会议配对， 健康与疾病中的生物能量学。为了帮助刺激网络机会和开发新的 合作，有三个联合会议设计的这些会议：代谢通量在健康 生物能量学和能量稳态，脂肪组织和代谢疾病。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Adipose Tissue: Energizing Good Fat, organized by Drs. Silvia Corvera, Kendra Bence and Rana Gupta. The conference will be held in Keystone, Colorado from January 15-19, 2023. Adipose tissue plays a critical role in metabolic health. Having a better understanding of its biology will guide development of new therapeutics for metabolic diseases. Therefore, this conference was developed to address key emerging questions in the field, from physiological to molecular, in order to facilitate synergy between established groups while also providing new trainees with a better picture of critical knowledge gaps. Key questions to be covered include: How do different adipose tissue depots contribute to systemic metabolism? How many types of adipocytes exist, and how do they contribute to the functions of different depots? How do adipocytes develop from progenitor cells? How do elements such as immune cells, vasculature and innervation influence their development? And finally, how do adipocyte lipid droplets and mitochondria develop, function and influence systemic metabolic homeostasis? There will also be discussions on how to envision research on adipose tissue in relation to the broader topic of human health. Adipose tissue disfunction, as manifested by obesity and metabolic disease, disproportionally affects groups underrepresented in medicine and research. Therefore, this health inequity will be addressed through a keynote address as well as a health disparities workshop. This program will also include a career development workshop for trainees. Finally, this conference will be paired with the Keystone Symposia conference on Bioenergetics in Health and Diseases. In order to help stimulate networking opportunities and develop new collaborations, there have been three joint sessions designed for these conferences: Metabolic Flux in Health and Disease, Bioenergetics and Energy Homeostasis, and Adipose Tissue and Metabolic Diseases.