Gut-Brain Axis

肠脑轴

• 批准号: 10467819
• 负责人: Thale Cross Jarvis
• 金额: $ 1.72万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467819
• 关键词: Academia; Area; Autonomic nervous system; Behavior; Canada; Central Nervous System Diseases; Collaborations; Communication; Desire for food; Disease; Educational workshop; Endocrine; Enteric Nervous System; Future; Gastrointestinal tract structure; Health; Human; Immune; Immune System Diseases; Immune signaling; Immunity; Immunologist; Industry; Inflammation; Investments; Knowledge; Learning; Mediating; Mentors; Metabolic; Metabolic Diseases; Metabolic Pathway; Methodology; Neuraxis; Neurons; Obesity; Outcome; Participant; Pathway interactions; Physiology; Research; Research Personnel; Role; Scientist; System; Technology; Translations; Vagus nerve structure; Work; career; clinical implementation; clinical practice; gastrointestinal; gut-brain axis; hormonal signals; improved; interest; meetings; microbiome; nervous system disorder; neurobiological mechanism; neuropsychiatric disorder; nonalcoholic steatohepatitis; novel strategies; posters; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Gut-Brain Axis, organized by Drs. Ann Weber, Sarkis Mazmanian and Scott Sternson. The conference will be held in Banff, Canada from March 20- 23, 2022. The gut-brain axis encompasses bidirectional communication between the gastrointestinal tract and the central nervous system (CNS). This is mediated via the autonomic nervous system, including the vagus nerve and enteric nervous system (ENS), and endocrine, immune, and metabolic pathways. These systems coordinate physiology and behavior in health and disease. The underlying mechanisms and pathways are now being elucidated in this emerging area of scientific interest. Understanding the gut-brain axis augments neurobiological mechanisms and provides opportunities to treat CNS disorders from the periphery as well as metabolic and immunologic diseases, including diverse conditions ranging from obesity to nonalcoholic steatohepatitis to neurologic and neuropsychiatric disorders. This meeting will bring together basic and applied scientists from across academia and industry to advance our understanding of gut-brain signaling. By highlighting the latest research across the components of the gut-brain axis, including vagal and ENS circuits and gut hormone and immune signaling, the role of the microbiome, and the gut-brain axis in health and disease, this meeting will catalyze increased interest, investment and cross-disciplinary collaborations to advance promising new approaches to improving human health. Finally, this meeting is being paired with the Keystone Symposia conference, Neuronal Control of Appetite. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations in these fields.

抽象的 请求支持题为“肠-脑轴”的 Keystone 研讨会，该会议由 Drs 组织。安 韦伯、萨基斯·马兹马尼安和斯科特·斯特恩森。会议将于3月20日至3月20日在加拿大班夫举行 2022 年 23 日。 肠脑轴包括胃肠道和中枢之间的双向通讯 神经系统（CNS）。这是通过自主神经系统介导的，包括迷走神经和 肠神经系统 (ENS) 以及内分泌、免疫和代谢途径。这些系统协调 健康和疾病中的生理和行为。目前正在研究潜在的机制和途径 在这个新兴的科学兴趣领域得到了阐明。了解肠脑轴可以增强 神经生物学机制，并提供从外周和周围治疗中枢神经系统疾病的机会 代谢和免疫疾病，包括从肥胖到非酒精等多种疾病 脂肪性肝炎导致神经系统和神经精神疾病。本次会议将汇集基础和应用 来自学术界和工业界的科学家们致力于增进我们对肠脑信号传导的理解。经过 重点介绍肠脑轴各组成部分的最新研究，包括迷走神经和 ENS 回路 肠道激素和免疫信号、微生物组的作用以及肠-脑轴在健康和健康方面的作用 疾病，本次会议将促进更多的兴趣、投资和跨学科合作，以 推进有前景的新方法来改善人类健康。最后，本次会议与 Keystone 研讨会，食欲的神经元控制。会议将分享会议内容并提供 两个会议的参与者在这些领域进行互动和开展新合作的最佳场所 字段。