Gut-Brain Axis

摘要 请求支持由Ann博士组织的题为肠脑轴心的Keystone研讨会 韦伯、萨基斯·马兹马尼安和斯科特·斯特恩森。会议将于3月20日至20日在加拿大班夫举行- 2022年23年。 胃肠-脑轴包括胃肠道和中枢神经系统之间的双向通讯。 神经系统(CNS)。这是通过自主神经系统调节的，包括迷走神经和 肠道神经系统(ENS)，以及内分泌、免疫和代谢途径。这些系统协调 健康和疾病中的生理和行为。潜在的机制和途径现在是 在这一新兴的科学兴趣领域进行了阐明。了解肠道-脑轴有助于增强 神经生物学机制，并提供机会治疗中枢神经系统疾病从外围以及 代谢和免疫疾病，包括从肥胖到非酒精性疾病的各种情况 脂肪性肝炎到神经和神经精神障碍。本次会议将汇集基础知识和应用知识 来自学术界和工业界的科学家推动我们对肠道-大脑信号的理解。通过 重点介绍了肠脑轴组件的最新研究，包括迷走神经和ENS回路 和肠道激素和免疫信号，微生物组的作用，以及肠道-脑轴在健康和 疾病，这次会议将促进更多的兴趣、投资和跨学科合作，以 提出改善人类健康的有希望的新方法。最后，这次会议将与 Keystone研讨会，食欲的神经元控制。这些会议将分享会议内容并提供 为两个会议的与会者提供最佳场所，以便在这些会议中进行互动并开展新的协作 菲尔兹。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Gut-Brain Axis, organized by Drs. Ann Weber, Sarkis Mazmanian and Scott Sternson. The conference will be held in Banff, Canada from March 20- 23, 2022. The gut-brain axis encompasses bidirectional communication between the gastrointestinal tract and the central nervous system (CNS). This is mediated via the autonomic nervous system, including the vagus nerve and enteric nervous system (ENS), and endocrine, immune, and metabolic pathways. These systems coordinate physiology and behavior in health and disease. The underlying mechanisms and pathways are now being elucidated in this emerging area of scientific interest. Understanding the gut-brain axis augments neurobiological mechanisms and provides opportunities to treat CNS disorders from the periphery as well as metabolic and immunologic diseases, including diverse conditions ranging from obesity to nonalcoholic steatohepatitis to neurologic and neuropsychiatric disorders. This meeting will bring together basic and applied scientists from across academia and industry to advance our understanding of gut-brain signaling. By highlighting the latest research across the components of the gut-brain axis, including vagal and ENS circuits and gut hormone and immune signaling, the role of the microbiome, and the gut-brain axis in health and disease, this meeting will catalyze increased interest, investment and cross-disciplinary collaborations to advance promising new approaches to improving human health. Finally, this meeting is being paired with the Keystone Symposia conference, Neuronal Control of Appetite. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations in these fields.