Engineering Multi-Cellular Living Systems

工程多细胞生命系统

• 批准号: 10462913
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462913
• 关键词: Address; Area; Behavior; Biochemical; Biological; Biological Process; Cell Communication; Cells; Collaborations; Colorado; Communities; Complex; Development; Developmental Biology; Discipline; Disease; Educational workshop; Engineering; Environment; Ethics; Future; Goals; Health; Human; Industry; Knowledge; Learning; Medicine; Mentors; Methodology; Methods; Modeling; Montserrat; Natural regeneration; Organism; Organoids; Outcome; Process; Research; Research Personnel; Robot; Scientist; Subcellular structure; System; Technology; Translations; Work; career; clinical practice; design; interest; mechanical signal; multidisciplinary; novel strategies; organ on a chip; posters; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Engineering Multi-Cellular Living Systems organized by Drs. Roger D. Kamm, Nuria Montserrat Pulido, Jianping Fu. The conference will be held in Keystone, Colorado from April 3-6, 2022. Developing the capability to design, engineer and produce complex, multi-cellular engineered living systems (M-CELS) to emulate natural processes (development, regeneration, and disease) or to create new functionality is a grand challenge facing the scientific community. The manufacturing and design of these complex multicellular machines and systems (e.g., organ-on-chip models, biological robots, and organoids) require fundamental understanding of interactions between cells and their environment, their control by biochemical and mechanical cues, and coordinated behavior of functional cell clusters through computational and experimental methods. Cell interactions, controls across scales (from subcellular structures to multi- cellular systems) and behaviors will be central themes of the conference. The primary aim of this conference is to bring together a multidisciplinary group of forward-looking researchers seeking to explore these complex biological interactions and the emergent behaviors they produce, with the goal of creating responsibly engineered multi-cellular systems with specific functions.

抽象的 请求支持Keystone研讨会会议标题为“工程多细胞生活系统” 由Drs组织。 Roger D. Kamm，Nuria Montserrat Pulido，Jianping Fu。会议将在 Keystone，科罗拉多州，从2022年4月3日至6日。 开发设计，设计和生产复杂的多细胞工程生活系统的能力 （M-CELS）模拟自然过程（发展，再生和疾病）或创建新的 功能是科学界面临的巨大挑战。这些的制造和设计 复杂的多细胞机器和系统（例如，芯片上的器官模型，生物机器人和器官） 需要基本了解细胞与其环境之间的相互作用，他们的控制 生化和机械提示，以及通过计算的功能细胞簇的协调行为 和实验方法。细胞相互作用，跨尺度的控制（从亚细胞结构到多 蜂窝系统）和行为将是会议的中心主题。这次会议的主要目的 是汇集一个跨学科的远观研究人员，他们试图探索这些复杂 生物互动及其产生的新兴行为，目的是负责任地创造 具有特定功能的工程多细胞系统。