Engineering Multi-Cellular Living Systems

工程多细胞生命系统

• 批准号: 10462913
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462913
• 关键词: Address; Area; Behavior; Biochemical; Biological; Biological Process; Cell Communication; Cells; Collaborations; Colorado; Communities; Complex; Development; Developmental Biology; Discipline; Disease; Educational workshop; Engineering; Environment; Ethics; Future; Goals; Health; Human; Industry; Knowledge; Learning; Medicine; Mentors; Methodology; Methods; Modeling; Montserrat; Natural regeneration; Organism; Organoids; Outcome; Process; Research; Research Personnel; Robot; Scientist; Subcellular structure; System; Technology; Translations; Work; career; clinical practice; design; interest; mechanical signal; multidisciplinary; novel strategies; organ on a chip; posters; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Engineering Multi-Cellular Living Systems organized by Drs. Roger D. Kamm, Nuria Montserrat Pulido, Jianping Fu. The conference will be held in Keystone, Colorado from April 3-6, 2022. Developing the capability to design, engineer and produce complex, multi-cellular engineered living systems (M-CELS) to emulate natural processes (development, regeneration, and disease) or to create new functionality is a grand challenge facing the scientific community. The manufacturing and design of these complex multicellular machines and systems (e.g., organ-on-chip models, biological robots, and organoids) require fundamental understanding of interactions between cells and their environment, their control by biochemical and mechanical cues, and coordinated behavior of functional cell clusters through computational and experimental methods. Cell interactions, controls across scales (from subcellular structures to multi- cellular systems) and behaviors will be central themes of the conference. The primary aim of this conference is to bring together a multidisciplinary group of forward-looking researchers seeking to explore these complex biological interactions and the emergent behaviors they produce, with the goal of creating responsibly engineered multi-cellular systems with specific functions.

摘要