Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)

加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASAnet)

• 批准号: 10629397
• 负责人: Pedro Enrique Cahn
• 金额: $ 315.93万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629397
• 关键词: Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Adolescent; Argentina; Articulation; Behavioral; Biometry; Brazil; COVID-19 impact; COVID-19 pandemic; COVID-19 pandemic effects; Caribbean region; Caring; Central America; Chile; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Complex; Continuity of Patient Care; Country; Data; Data Coordinating Center; Data Science; Data Set; Data Sources; Databases; Diabetes Mellitus; Diagnostic Procedure; Disease; Disease Outcome; Education; Elderly; Epidemic; Epidemiology; Funding; Goals; Growth; HIV; HIV therapy; Haiti; Health; Health Policy; Health Sciences; Healthcare Systems; Honduras; Incubated; Individual; Inequity; Informatics; Information Sciences; Infrastructure; Injecting drug user; Institution; International; Latin America; Leadership; Life Expectancy; Link; Mentors; Mentorship; Methodology; Methods; Mexico; Migrant; Observational Study; Outcome; Patient-Focused Outcomes; Patients; Persons; Peru; Policies; Population; Population Policies; Pregnant Women; Prevention; Productivity; Prospective cohort; Public Health; Registries; Reporting; Research; Research Personnel; Resource Informatics; Retrospective cohort; Science; Site; South America; Statistical Data Interpretation; Training Programs; Training Support; Translating; Translational Research; Treatment outcome; Tuberculosis; United States National Institutes of Health; Vulnerable Populations; Work; analytical method; biomedical informatics; care delivery; clinical application; clinical care; clinical practice; clinical research site; co-infection; cohort; data framework; data harmonization; data management; data quality; data sharing; data tools; epidemiologic data; epidemiology study; experience; follow-up; health determinants; health disparity; improved; innovation; insight; member; men who have sex with men; mortality; novel; novel strategies; population health; preservation; programs; prospective; psychosocial; quality assurance; skills; social health determinants; transcriptomics; transgender; transgender women; treatment program; tuberculosis treatment

PROJECT SUMMARY/ABSTRACT The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network within the International epidemiology Databases to Evaluate AIDS (leDEA) program. CCASAnet was created in 2006 during the first leDEA funding cycle and has brought together clinical, statistical, epidemiologic, and informatics resources from HIV clinical care and research sites in Argentina, Brazil, Chile, Haiti, Honduras, Mexico, and Peru, along with a coordinating center in Nashville, USA. Together, the members of the CCASAnet collaboration respond to scientific opportunities arising in the region and across HIV research networks worldwide. The CCASAnet Data Coordinating Center at Vanderbilt University Medical Center (VDCC) manages the CCASAnet consortium and works to harmonize and analyze the complex databases generated by participating sites. The VDCC also provides mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region. Over the next five years, CCASAnet will assess inequities in the HIV continuum of care; the impact of the COVID-19 pandemic on HIV care delivery; outcomes in vulnerable populations including migrants, those "lost to follow-up," and pregnant women; determinants and prevention of non- communicable diseases; and treatment outcomes in TB patients with and without HIV. We will also characterize psychosocial, behavioral, and non-communicable disease clinical outcomes in adolescents, transgender, and older persons through new prospective cohorts nested in the CCASAnet retrospective clinical cohort. We will continue to develop and apply innovative biostatistics and informatics methods, grow our productive collaborations with other IeDEA regions, and provide leadership in the site assessment, data harmonization, and data sharing initiatives. Through these activities, CCASAnet 4 will help advance both the science of HIV epidemiology and the information science that underpins international research collaboration.

项目总结/文摘

项目成果

Association Between Frailty and HIV-Associated Neurodegenerative Disorders Among Older Adults Living with HIV.

• DOI: 10.1089/aid.2017.0100
• 发表时间: 2018-05
• 期刊: AIDS research and human retroviruses
• 影响因子: 1.5
• 作者: Alfonso Zamudio-Rodríguez;Pablo F Belaunzarán-Zamudio;J. Sierra-Madero;J. Cuellar-Rodríguez;B. Crabtree-Ramírez;J. Alcala-Zermeno;H. Amièva;J. Ávila-Funes

Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil.

• DOI: 10.3389/fmed.2022.972145
• 发表时间: 2022
• 期刊: Frontiers in medicine
• 影响因子: 3.9

N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions.

• DOI: 10.1186/s12866-016-0872-7
• 发表时间: 2016-10-28
• 期刊: BMC microbiology
• 影响因子: 4.2
• 作者: Amaral EP;Conceição EL;Costa DL;Rocha MS;Marinho JM;Cordeiro-Santos M;D'Império-Lima MR;Barbosa T;Sher A;Andrade BB
• 通讯作者: Andrade BB

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication.

感染时肺部的炎症微环境控制着 SARS-CoV-2 复制的先天控制。

• DOI: 10.1101/2024.03.27.586885
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Baker,PaulJ;Bohrer,AndreaC;Castro,Ehydel;Amaral,EduardoP;Snow-Smith,Maryonne;Torres-Juárez,Flor;Gould,SydneeT;Queiroz,ArturTL;Fukutani,EduardoR;Jordan,CassandraM;Khillan,JaspalS;Cho,Kyoungin;Barber,DanielL;Andrade,Brun
• 通讯作者: Andrade,Brun

The impact of earthquakes in Latin America on the continuity of HIV care: A retrospective observational cohort study.

拉丁美洲地震对艾滋病毒护理连续性的影响：一项回顾性观察队列研究。

• DOI: 10.1016/j.puhip.2024.100479
• 发表时间: 2024
• 期刊: Public health in practice (Oxford, England)
• 作者: Gorsline,ChelseaA;Lotspeich,SarahC;Belaunzarán-Zamudio,PabloF;Mejia,Fernando;Cortes,ClaudiaP;Crabtree-Ramírez,Brenda;Severe,DamoclesPatrice;Rouzier,Vanessa;McGowan,CatherineC;Rebeiro,PeterF
• 通讯作者: Rebeiro,PeterF