Caribbean, Central and South America network for HIV epidemiology (CCASnet)

加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASnet)

• 批准号: 8711188
• 负责人: Pedro Enrique Cahn
• 金额: $ 227.67万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8711188
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adolescent and Young Adult; Caribbean region; Caring; Central America; Cities; Clinical; Clinical Data; Clinical Research; Collaborations; Communicable Diseases; Complex; Country; Data Coordinating Center; Databases; Disease Outcome; Education; Epidemic; Epidemiology; Funding; Future; Growth; HIV; HIV Infections; Hepatitis; Human; Human Papillomavirus; Infection; Informatics; Information Sciences; International; Latin America; Leadership; Mentors; Methods; Mexico; Outcome; Pattern; Research; Research Personnel; Resources; Science; Site; Source; South America; Specimen; Translational Research; Tuberculosis; antiretroviral therapy; clinical care; clinical research site; data management; data sharing; innovation; programs; repository

DESCRIPTION (provided by applicant): The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network that is responsive to scientific opportunities arising in the region and across International Epidemiologic Databases to Evaluate AIDS (leDEA) regions worldwide. This successful collaboration, created during the first leDEA funding cycle, has resulted in the productive enrichment and merging of human and technological resources from HIV clinical care and research sites in Port-au-Prince, Mexico City, Tegucigalpa, Lima, Rio de Janeiro, Buenos Aires, and Santiago, and the Vanderbilt Data Coordinating Center (DCC). The Vanderbilt DCC will continue to effectively harmonize and analyze complex databases and manage the CCASAnet 2.0 consortium. The project will conduct and facilitate research using the shared data repository to answer questions that cannot be answered by any single source. The clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region will be evaluated. Studies are proposed to determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, and human papillomavirus. Factors uniquely related to adolescents and young adults with HIV will be addressed across the region. Innovative biostatistical and informatics methods will be developed and applied. Biologic specimen repositories will be established that will facilitate future translational research. Programs for mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region will be implemented. By these activities, CCASAnet 2.0 will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration. RELEVANCE: The project seeks to articulate contemporary research questions that are important to the dynamics of the global HIV epidemic and other infectious diseases within CCASAnet consortium countries. The proposed research will increase the understanding of similarities and differences in patterns of HIV care and disease outcomes in the Caribbean and Latin America, and will address issues that are also compelling in other regional settings

描述（由申请人提供）： 加勒比海，中美洲和南美艾滋病毒流行病学网络（CCASANET）是一个既定且富有成效的网络，对全球评估艾滋病地区（LEDEA）地区的该地区以及国际流行病学数据库的科学机会响应。在第一个Ledea资助周期中创建的这种成功的合作，从HIV临床护理和研究地点，墨西哥城，墨西哥城，TegucigaLpa，Lima，Rio de Janeiro，Rio De Janeiro，Buenos Aires以及Santiago以及Vanderbilt Data Coildation Coildation Coilding Coriordin（Dccording coordined Coilding coording coordined Coilding（Dccording）中心，从HIV临床护理和研究站点促进了人力和技术资源的富有成效的丰富和合并。 Vanderbilt DCC将继续有效地协调和分析复杂数据库并管理CCASANET 2.0联盟。该项目将使用共享数据存储库进行并促进研究，以回答任何单一来源无法回答的问题。将评估与HIV感染和抗逆转录病毒疗法有关的临床结果和并发症。提出了研究以确定除HIV以外的其他感染的影响，尤其是结核病，肝炎和人乳头瘤病毒。与青少年和艾滋病毒年轻人有关的因素将在整个地区均可解决。将开发和应用创新的生物统计和信息学方法。将建立生物标本存储库，以促进未来的转化研究。将实施指导和教育的计划，以增强CCASANET站点，促进初级研究人员的临床研究和数据管理能力的计划，并促进该地区的科学领导力的持续增长。通过这些活动，CCASANET 2.0将有助于推进艾滋病毒流行病学科学，以及基于国际研究合作的信息科学。 关联： 该项目旨在阐明当代研究问题，这些问题对CCASANET联盟国家内的全球HIV流行病和其他传染病的动态很重要。拟议的研究将增加对加勒比海和拉丁美洲艾滋病毒护理和疾病结果模式的相似性和差异的理解，并将解决在其他地区环境中也引人注目的问题