Caribbean, Central and South America network for HIV epidemiology (CCASnet)

加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASnet)

• 批准号: 8711188
• 负责人: Pedro Enrique Cahn
• 金额: $ 227.67万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8711188
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adolescent and Young Adult; Caribbean region; Caring; Central America; Cities; Clinical; Clinical Data; Clinical Research; Collaborations; Communicable Diseases; Complex; Country; Data Coordinating Center; Databases; Disease Outcome; Education; Epidemic; Epidemiology; Funding; Future; Growth; HIV; HIV Infections; Hepatitis; Human; Human Papillomavirus; Infection; Informatics; Information Sciences; International; Latin America; Leadership; Mentors; Methods; Mexico; Outcome; Pattern; Research; Research Personnel; Resources; Science; Site; Source; South America; Specimen; Translational Research; Tuberculosis; antiretroviral therapy; clinical care; clinical research site; data management; data sharing; innovation; programs; repository

DESCRIPTION (provided by applicant): The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network that is responsive to scientific opportunities arising in the region and across International Epidemiologic Databases to Evaluate AIDS (leDEA) regions worldwide. This successful collaboration, created during the first leDEA funding cycle, has resulted in the productive enrichment and merging of human and technological resources from HIV clinical care and research sites in Port-au-Prince, Mexico City, Tegucigalpa, Lima, Rio de Janeiro, Buenos Aires, and Santiago, and the Vanderbilt Data Coordinating Center (DCC). The Vanderbilt DCC will continue to effectively harmonize and analyze complex databases and manage the CCASAnet 2.0 consortium. The project will conduct and facilitate research using the shared data repository to answer questions that cannot be answered by any single source. The clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region will be evaluated. Studies are proposed to determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, and human papillomavirus. Factors uniquely related to adolescents and young adults with HIV will be addressed across the region. Innovative biostatistical and informatics methods will be developed and applied. Biologic specimen repositories will be established that will facilitate future translational research. Programs for mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region will be implemented. By these activities, CCASAnet 2.0 will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration. RELEVANCE: The project seeks to articulate contemporary research questions that are important to the dynamics of the global HIV epidemic and other infectious diseases within CCASAnet consortium countries. The proposed research will increase the understanding of similarities and differences in patterns of HIV care and disease outcomes in the Caribbean and Latin America, and will address issues that are also compelling in other regional settings

描述（由申请人提供）： 加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASAnet) 是一个成熟且富有成效的网络，该网络响应该地区以及全球艾滋病评估国际流行病学数据库 (leDEA) 地区出现的科学机会。这一成功的合作是在第一个 leDEA 资助周期内建立的，导致太子港、墨西哥城、特古西加尔巴、利马、里约热内卢、布宜诺斯艾利斯和圣地亚哥的艾滋病毒临床护理和研究中心以及范德比尔特数据协调中心 (DCC) 的人力和技术资源得到了富有成效的丰富和合并。范德比尔特 DCC 将继续有效地协调和分析复杂的数据库并管理 CCASAnet 2.0 联盟。该项目将使用共享数据存储库进行和促进研究，以回答任何单一来源无法回答的问题。将评估该地区与艾滋病毒感染和抗逆转录病毒治疗相关的临床结果和并发症。建议开展研究以确定艾滋病毒以外的感染的影响，特别是结核病、肝炎和人乳头瘤病毒。该地区将讨论与青少年和年轻人感染艾滋病毒相关的独特因素。将开发和应用创新的生物统计和信息学方法。将建立生物样本库，以促进未来的转化研究。将实施指导和教育计划，以增强 CCASAnet 站点的临床研究和数据管理能力、晋升初级研究人员并促进该地区科学领导力的持续发展。通过这些活动，CCASAnet 2.0 将有助于推进艾滋病毒流行病学科学以及支撑国际研究合作的信息科学。 关联： 该项目旨在阐明对 CCASAnet 联盟国家内全球艾滋病毒流行和其他传染病的动态非常重要的当代研究问题。拟议的研究将增进对加勒比地区和拉丁美洲艾滋病毒护理模式和疾病结果的相似性和差异的了解，并将解决其他区域环境中同样引人注目的问题