Caribbean, Central and South America network for HIV epidemiology (CCASnet)

描述(由申请人提供)： 加勒比、中美洲和南美洲艾滋病毒流行病学网络(CCASAnet)是一个成熟和富有成效的网络，它响应该区域和跨国际流行病学数据库出现的科学机会，评估世界各地的艾滋病(LeDEA)区域。这一成功的合作是在第一个leDEA供资周期中创建的，它已经使来自太子港、墨西哥城、特古西加尔巴、利马、里约热内卢、布宜诺斯艾利斯和圣地亚哥的艾滋病毒临床护理和研究基地以及范德比尔特数据协调中心(DCC)的人力和技术资源得到了富有成效的丰富和整合。Vanderbilt DCC将继续有效地协调和分析复杂的数据库，并管理CCASAnet 2.0联合体。该项目将利用共享数据储存库进行研究并为其提供便利，以回答任何单一来源无法回答的问题。将评估该地区与艾滋病毒感染和抗逆转录病毒治疗有关的临床结果和并发症。建议进行研究以确定艾滋病毒以外的其他感染，特别是结核病、肝炎和人类乳头瘤病毒的影响。将在整个区域处理与青少年和青年艾滋病毒携带者有关的独特因素。将开发和应用创新的生物统计和信息学方法。将建立生物标本库，为未来的翻译研究提供便利。将实施指导和教育计划，以增强CCASAnet网站的临床研究和数据管理能力，促进初级研究人员，并促进该地区科学领导地位的持续增长。通过这些活动，CCASAnet 2.0将有助于推动艾滋病毒流行病学科学和支撑国际研究合作的信息科学。 相关性： 该项目力求阐明当代的研究问题，这些问题对全球艾滋病毒流行的动态和亚太区域协调中心内的其他传染病的动态很重要。拟议的研究将增加对加勒比和拉丁美洲艾滋病毒护理和疾病结果模式的异同的了解，并将处理在其他区域环境中也令人信服的问题

DESCRIPTION (provided by applicant): The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network that is responsive to scientific opportunities arising in the region and across International Epidemiologic Databases to Evaluate AIDS (leDEA) regions worldwide. This successful collaboration, created during the first leDEA funding cycle, has resulted in the productive enrichment and merging of human and technological resources from HIV clinical care and research sites in Port-au-Prince, Mexico City, Tegucigalpa, Lima, Rio de Janeiro, Buenos Aires, and Santiago, and the Vanderbilt Data Coordinating Center (DCC). The Vanderbilt DCC will continue to effectively harmonize and analyze complex databases and manage the CCASAnet 2.0 consortium. The project will conduct and facilitate research using the shared data repository to answer questions that cannot be answered by any single source. The clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region will be evaluated. Studies are proposed to determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, and human papillomavirus. Factors uniquely related to adolescents and young adults with HIV will be addressed across the region. Innovative biostatistical and informatics methods will be developed and applied. Biologic specimen repositories will be established that will facilitate future translational research. Programs for mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region will be implemented. By these activities, CCASAnet 2.0 will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration. RELEVANCE: The project seeks to articulate contemporary research questions that are important to the dynamics of the global HIV epidemic and other infectious diseases within CCASAnet consortium countries. The proposed research will increase the understanding of similarities and differences in patterns of HIV care and disease outcomes in the Caribbean and Latin America, and will address issues that are also compelling in other regional settings