Caribbean, Central and South America network for HIV epidemiology (CCASnet)

描述（由申请人提供）： 加勒比、中美洲和南美洲艾滋病毒流行病学网络（CCASAnet）是一个已建立的富有成效的网络，它对该区域和全世界评价艾滋病的国际流行病学数据库（leDEA）区域出现的科学机会作出反应。在第一个leDEA供资周期期间建立的这一成功合作，使太子港、墨西哥城、特古西加尔帕、利马、里约热内卢、布宜诺斯艾利斯和圣地亚哥的艾滋病毒临床护理和研究地点以及范德比尔特数据协调中心的人力和技术资源得到了富有成效的充实和合并。范德比尔特DCC将继续有效地协调和分析复杂的数据库，并管理CCASAnet 2.0联盟。该项目将利用共享数据储存库开展和促进研究，以回答任何单一来源都无法回答的问题。将评价该区域与艾滋病毒感染和抗逆转录病毒疗法有关的临床结果和并发症。建议进行研究，以确定艾滋病毒以外的感染，特别是结核病，肝炎和人乳头瘤病毒的影响。将在整个区域处理与感染艾滋病毒的青少年和青年人特有的相关因素。将开发和应用创新的生物统计和信息学方法。将建立生物标本库，以促进未来的转化研究。将实施指导和教育计划，以提高CCASAnet站点的临床研究和数据管理能力，促进初级研究人员，并促进该地区科学领导力的持续增长。通过这些活动，CCASAnet 2.0将有助于推进艾滋病毒流行病学和支持国际研究合作的信息科学。 相关性： 该项目力求阐明对全球艾滋病毒流行病和其他传染病在CCASAnet联合体国家内的动态具有重要意义的当代研究问题。拟议的研究将增进对加勒比和拉丁美洲艾滋病毒护理模式和疾病结果的相似性和差异的了解，并将解决在其他区域环境中同样紧迫的问题

DESCRIPTION (provided by applicant): The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network that is responsive to scientific opportunities arising in the region and across International Epidemiologic Databases to Evaluate AIDS (leDEA) regions worldwide. This successful collaboration, created during the first leDEA funding cycle, has resulted in the productive enrichment and merging of human and technological resources from HIV clinical care and research sites in Port-au-Prince, Mexico City, Tegucigalpa, Lima, Rio de Janeiro, Buenos Aires, and Santiago, and the Vanderbilt Data Coordinating Center (DCC). The Vanderbilt DCC will continue to effectively harmonize and analyze complex databases and manage the CCASAnet 2.0 consortium. The project will conduct and facilitate research using the shared data repository to answer questions that cannot be answered by any single source. The clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region will be evaluated. Studies are proposed to determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, and human papillomavirus. Factors uniquely related to adolescents and young adults with HIV will be addressed across the region. Innovative biostatistical and informatics methods will be developed and applied. Biologic specimen repositories will be established that will facilitate future translational research. Programs for mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region will be implemented. By these activities, CCASAnet 2.0 will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration. RELEVANCE: The project seeks to articulate contemporary research questions that are important to the dynamics of the global HIV epidemic and other infectious diseases within CCASAnet consortium countries. The proposed research will increase the understanding of similarities and differences in patterns of HIV care and disease outcomes in the Caribbean and Latin America, and will address issues that are also compelling in other regional settings