BIOMARKER DISCOVERY FOR TUBERCULOSIS INFECTION AND DISEASE

加勒比、中美洲和南美洲艾滋病毒流行病学网络是一个既定的 富有成效的网络，响应该地区和国际上出现的科学机会 评估全球艾滋病(LeDEA)地区的流行病学数据库。这一成功的合作， 在第一个leDEA供资周期期间创建的，已导致生产性丰富和合并 来自墨西哥城太子港艾滋病毒临床护理和研究地点的人力和技术资源 特古西加尔巴、利马、里约热内卢、布宜诺斯艾利斯和圣地亚哥，以及范德比尔特数据协调中心 中心(DCC)。范德比尔特数据中心将继续有效地协调和分析复杂的数据库 并管理CCASAnet 2.0财团。该项目将使用共享的 数据存储库，用于回答任何单一来源都无法回答的问题。临床转归 并将评估该地区与艾滋病毒感染和抗逆转录病毒治疗有关的并发症。研究 建议用来确定艾滋病毒以外的感染的影响，特别是结核病、肝炎和 人乳头瘤病毒。将解决与青少年和青年艾滋病毒携带者有关的独特因素 在整个地区。将开发和应用创新的生物统计和信息学方法。生物学 将建立标本储存库，为未来的翻译研究提供便利。计划的目标 指导和教育，以加强中国CASAnet网站的临床研究和数据管理能力， 提拔初级研究人员，并催化该地区科学领导力的持续增长 实施。通过这些活动，CCASAnet 2.0将有助于推动艾滋病毒流行病学科学， 以及支撑国际研究合作的信息科学。 相关性(请参阅说明)： 该项目试图阐明当代研究问题，这些问题对地球动力学很重要。 亚洲及太平洋区域协调中心联盟国家内的全球艾滋病毒流行和其他传染病。建议数 研究将增加对艾滋病毒护理和疾病模式的相似和不同的理解 在加勒比和拉丁美洲取得成果，并将解决在其他地区也令人信服的问题 区域设置

The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network that is responsive to scientific opportunities arising in the region and across International Epidemiologic Databases to Evaluate AIDS (leDEA) regions worldwide. This successful collaboration, created during the first leDEA funding cycle, has resulted in the productive enrichment and merging of human and technological resources from HIV clinical care and research sites in Port-au-Prince, Mexico City, Tegucigalpa, Lima, Rio de Janeiro, Buenos Aires, and Santiago, and the Vanderbilt Data Coordinating Center (DCC). The Vanderbilt DCC will continue to effectively harmonize and analyze complex databases and manage the CCASAnet 2.0 consortium. The project will conduct and facilitate research using the shared data repository to answer questions that cannot be answered by any single source. The clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region will be evaluated. Studies are proposed to determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, and human papillomavirus. Factors uniquely related to adolescents and young adults with HIV will be addressed across the region. Innovative biostatistical and informatics methods will be developed and applied. Biologic specimen repositories will be established that will facilitate future translational research. Programs for mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region will be implemented. By these activities, CCASAnet 2.0 will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration. RELEVANCE (See instructions): The project seeks to articulate contemporary research questions that are important to the dynamics ofthe global HIV epidemic and other infectious diseases within CCASAnet consortium countries. The proposed research will increase the understanding of similarities and differences in patterns of HIV care and disease outcomes in the Caribbean and Latin America, and will address issues that are also compelling in other regional settings