BIOMARKER DISCOVERY FOR TUBERCULOSIS INFECTION AND DISEASE

加勒比、中美洲和南美洲艾滋病毒流行病学网络（CCASAnet）是一个已建立的网络， 建立一个富有成效的网络，对本区域和整个国际社会出现的科学机会作出反应 流行病学数据库，以评估艾滋病（leDEA）地区的世界各地。这次成功的合作， 在第一个leDEA融资周期中创建，导致了生产性的丰富和合并， 来自太子港、墨西哥城、 特古西加尔帕、利马、里约热内卢、布宜诺斯艾利斯和圣地亚哥，以及范德比尔特数据协调中心 中心（DCC）。范德比尔特DCC将继续有效地协调和分析复杂的数据库 并管理CCASAnet 2.0联盟。该项目将利用共享的 数据存储库来回答任何单一来源都无法回答的问题。的临床结局 将对该地区与艾滋病毒感染和抗逆转录病毒疗法有关的并发症进行评估。研究 建议确定艾滋病毒以外的感染的影响，特别是结核病，肝炎， 人乳头瘤病毒将探讨与青少年和青年艾滋病毒感染者独特相关的因素 在整个地区。将开发和应用创新的生物统计和信息学方法。生物 将建立标本库，以促进今后的转化研究。方案 指导和教育，以提高CCASAnet站点的临床研究和数据管理能力， 促进初级研究人员，并促进该地区科学领导力的持续增长， 切实贯彻通过这些活动，CCASAnet 2.0将有助于推进艾滋病毒流行病学， 以及支撑国际研究合作的信息科学。 相关性（参见说明）： 该项目旨在阐明当代的研究问题，是重要的动态 在CCASAnet联合体国家内的全球艾滋病毒流行病和其他传染病。拟议 研究将增加对艾滋病毒护理和疾病模式的相似性和差异的理解 在加勒比和拉丁美洲取得的成果，并将处理在其他区域也具有紧迫性的问题。 区域设置

The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network that is responsive to scientific opportunities arising in the region and across International Epidemiologic Databases to Evaluate AIDS (leDEA) regions worldwide. This successful collaboration, created during the first leDEA funding cycle, has resulted in the productive enrichment and merging of human and technological resources from HIV clinical care and research sites in Port-au-Prince, Mexico City, Tegucigalpa, Lima, Rio de Janeiro, Buenos Aires, and Santiago, and the Vanderbilt Data Coordinating Center (DCC). The Vanderbilt DCC will continue to effectively harmonize and analyze complex databases and manage the CCASAnet 2.0 consortium. The project will conduct and facilitate research using the shared data repository to answer questions that cannot be answered by any single source. The clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region will be evaluated. Studies are proposed to determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, and human papillomavirus. Factors uniquely related to adolescents and young adults with HIV will be addressed across the region. Innovative biostatistical and informatics methods will be developed and applied. Biologic specimen repositories will be established that will facilitate future translational research. Programs for mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region will be implemented. By these activities, CCASAnet 2.0 will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration. RELEVANCE (See instructions): The project seeks to articulate contemporary research questions that are important to the dynamics ofthe global HIV epidemic and other infectious diseases within CCASAnet consortium countries. The proposed research will increase the understanding of similarities and differences in patterns of HIV care and disease outcomes in the Caribbean and Latin America, and will address issues that are also compelling in other regional settings