Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet)

加勒比、中南美洲艾滋病毒流行病学网络 (CCASAnet)

• 批准号: 10089682
• 负责人: Pedro Enrique Cahn
• 金额: $ 6.54万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-19 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10089682
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent and Young Adult; Adult; Aging; Alcohol or Other Drugs use; Americas; Aptitude; Argentina; Atmosphere; Biometry; Brazil; Calcium Channel; Cardiovascular Diseases; Caribbean region; Caring; Central America; Child; Childhood; Chile; Cities; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communicable Diseases; Complex; Continuity of Patient Care; Country; Data; Data Coordinating Center; Databases; Dengue; Development; Diagnosis; Discipline of obstetrics; Disease; Disease Outcome; Education; Epidemic; Epidemiology; Funding; Grant; Growth; Guidelines; HIV; HIV Infections; HIV antiretroviral; HIV-infected adolescents; Haiti; Health; Health Policy; Healthcare; Heart Diseases; Hepatitis; Honduras; Human Papillomavirus; Human immunodeficiency virus test; Individual; Infection; Infectious Disease Epidemiology; Informatics; Information Sciences; International; Knowledge; Latin America; Lead; Leadership; Liver Fibrosis; Malignant Neoplasms; Manuscripts; Measures; Mentors; Methods; Mexico; Monitor; Observational Study; Outcome; Pattern; Persons; Peru; Population; Populations at Risk; Pregnancy Outcome; Principal Investigator; Process; Public Health; Reporting; Research; Research Design; Research Personnel; Resource Informatics; Science; Site; South America; Statistical Methods; Time; Trust; Tuberculosis; United States National Institutes of Health; Universities; Viral; Vulnerable Populations; Work; Writing; antiretroviral therapy; base; care outcomes; clinical care; clinical research site; co-infection; cohort; data harmonization; data management; data quality; experience; improved; informatics tool; innovation; medication compliance; member; neuropsychiatric disorder; novel; programs; skills; social stigma; success; transmission process; treatment guidelines; treatment program; trend

PROJECT SUMMARY/ABSTRACT The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network within the International epidemiologic Databases to Evaluate AIDS (leDEA) program. CCASAnet was created in 2006 during the first leDEA funding cycle and has brought together clinical, statistical, epidemiologic, and informatics resources from HIV clinical care and research sites in Port-au-Prince, Haiti; Mexico City, Mexico; Tegucigalpa, Honduras; Lima, Peru; Buenos Aires, Argentina; Santiago, Chile; and Rio de Janeiro, Belo Horizonte, and Sao Paulo, Brazil, along with a coordinating center in Nashville, USA. Together, the members of the CCASAnet collaboration respond to scientific opportunities arising in the region and across HIV research networks worldwide. The CCASAnet Data Coordinating Center at Vanderbilt University (VDCC) manages the CCASAnet consortium and works to harmonize and analyze the complex databases generated by participating sites. The VDCC also provides mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region. Over the next five years, CCASAnet will evaluate clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region, and determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, human papillomavirus, and dengue. CCASAnet studies will investigate non-communicable diseases such as cancer and heart disease, regional trends in the HIV epidemic and its impact on vulnerable populations, and other issues of public health importance in Latin America. Additionally, studies will address factors uniquely related to children, adolescents, and young adults with HIV. We will continue to develop and apply innovative biostatistics and informatics methods, grow our productive collaborations with other IeDEA regions, and provide leadership in the site assessment and data harmonization initiatives. Through these activities, CCASAnet 3.0 will help advance both the science of HIV epidemiology and the information science that underpins international research collaboration.

项目摘要/摘要 加勒比、中美洲和南美洲艾滋病毒流行病学网络是一个既定的 在评估艾滋病的国际流行病学数据库(LeDEA)方案内建立了富有成效的网络。 CCASAnet是在2006年第一个leDEA供资周期期间创建的，汇集了临床、 来自太子港艾滋病毒临床护理和研究站点的统计、流行病学和信息学资源， 海地；墨西哥墨西哥城；洪都拉斯特古西加尔巴；秘鲁利马；阿根廷布宜诺斯艾利斯；智利圣地亚哥；以及 里约热内卢、贝洛奥里藏特和巴西圣保罗，以及美国纳什维尔的协调中心。 CCASAnet协作成员共同应对该区域出现的科学机会 以及世界各地的艾滋病毒研究网络。位于范德比尔特的CCASAnet数据协调中心 大学(VDCC)管理CCASAnet联合体，并致力于协调和分析建筑群 参与站点生成的数据库。VDCC还提供辅导和教育，以提高 CCASAnet网站的临床研究和数据管理能力，促进初级研究人员，以及 促进该地区科学领导地位的持续增长。在未来五年，CCASAnet将评估 与该区域艾滋病毒感染和抗逆转录病毒治疗有关的临床结果和并发症；以及 确定艾滋病毒以外的其他感染，特别是结核病、肝炎、人乳头瘤病毒、 还有登革热。CCASAnet研究将调查癌症和心脏等非传染性疾病 疾病、艾滋病毒流行的区域趋势及其对弱势人口的影响，以及其他 拉丁美洲公共卫生的重要性。此外，研究将解决与儿童独特相关的因素， 青少年和感染艾滋病毒的青壮年。我们将继续开发和应用创新的生物统计学和 信息学方法，加强我们与其他IeDEA区域的富有成效的合作，并在以下方面提供领导 现场评估和数据协调举措。通过这些活动，CCASAnet 3.0将提供帮助 推动艾滋病毒流行病学科学和支撑国际的信息科学 研究合作。