Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet)

加勒比、中南美洲艾滋病毒流行病学网络 (CCASAnet)

• 批准号: 10089682
• 负责人: Pedro Enrique Cahn
• 金额: $ 6.54万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-19 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10089682
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent and Young Adult; Adult; Aging; Alcohol or Other Drugs use; Americas; Aptitude; Argentina; Atmosphere; Biometry; Brazil; Calcium Channel; Cardiovascular Diseases; Caribbean region; Caring; Central America; Child; Childhood; Chile; Cities; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communicable Diseases; Complex; Continuity of Patient Care; Country; Data; Data Coordinating Center; Databases; Dengue; Development; Diagnosis; Discipline of obstetrics; Disease; Disease Outcome; Education; Epidemic; Epidemiology; Funding; Grant; Growth; Guidelines; HIV; HIV Infections; HIV antiretroviral; HIV-infected adolescents; Haiti; Health; Health Policy; Healthcare; Heart Diseases; Hepatitis; Honduras; Human Papillomavirus; Human immunodeficiency virus test; Individual; Infection; Infectious Disease Epidemiology; Informatics; Information Sciences; International; Knowledge; Latin America; Lead; Leadership; Liver Fibrosis; Malignant Neoplasms; Manuscripts; Measures; Mentors; Methods; Mexico; Monitor; Observational Study; Outcome; Pattern; Persons; Peru; Population; Populations at Risk; Pregnancy Outcome; Principal Investigator; Process; Public Health; Reporting; Research; Research Design; Research Personnel; Resource Informatics; Science; Site; South America; Statistical Methods; Time; Trust; Tuberculosis; United States National Institutes of Health; Universities; Viral; Vulnerable Populations; Work; Writing; antiretroviral therapy; base; care outcomes; clinical care; clinical research site; co-infection; cohort; data harmonization; data management; data quality; experience; improved; informatics tool; innovation; medication compliance; member; neuropsychiatric disorder; novel; programs; skills; social stigma; success; transmission process; treatment guidelines; treatment program; trend

PROJECT SUMMARY/ABSTRACT The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network within the International epidemiologic Databases to Evaluate AIDS (leDEA) program. CCASAnet was created in 2006 during the first leDEA funding cycle and has brought together clinical, statistical, epidemiologic, and informatics resources from HIV clinical care and research sites in Port-au-Prince, Haiti; Mexico City, Mexico; Tegucigalpa, Honduras; Lima, Peru; Buenos Aires, Argentina; Santiago, Chile; and Rio de Janeiro, Belo Horizonte, and Sao Paulo, Brazil, along with a coordinating center in Nashville, USA. Together, the members of the CCASAnet collaboration respond to scientific opportunities arising in the region and across HIV research networks worldwide. The CCASAnet Data Coordinating Center at Vanderbilt University (VDCC) manages the CCASAnet consortium and works to harmonize and analyze the complex databases generated by participating sites. The VDCC also provides mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region. Over the next five years, CCASAnet will evaluate clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region, and determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, human papillomavirus, and dengue. CCASAnet studies will investigate non-communicable diseases such as cancer and heart disease, regional trends in the HIV epidemic and its impact on vulnerable populations, and other issues of public health importance in Latin America. Additionally, studies will address factors uniquely related to children, adolescents, and young adults with HIV. We will continue to develop and apply innovative biostatistics and informatics methods, grow our productive collaborations with other IeDEA regions, and provide leadership in the site assessment and data harmonization initiatives. Through these activities, CCASAnet 3.0 will help advance both the science of HIV epidemiology and the information science that underpins international research collaboration.

项目摘要/摘要 加勒比海，中美洲和南美艾滋病毒流行病学网络（CCASANET）是已建立的， 评估艾滋病计划（LEDEA）计划的国际流行病学数据库中的生产网络。 CCASANET成立于2006年的第一个Ledea资助周期，并将临床汇集在一起​​， 来自Port-Au-rince的HIV临床护理和研究地点的统计，流行病学和信息学资源， 海地;墨西哥墨西哥城； Tegucigalpa，洪都拉斯；秘鲁利马；阿根廷布宜诺斯艾利斯；圣地亚哥，智利；和 里约热内卢（Rio de Janeiro），Belo Horizo​​nte和巴西的圣保罗（Sao Paulo），以及美国纳什维尔（Nashville）的协调中心。 CCASANET合作的成员一起回应了该地区的科学机会 以及全球跨越艾滋病毒研究网络。范德比尔特的CCASANET数据协调中心 大学（VDCC）管理CCASANET财团，并致力于协调和分析该综合体 通过参与站点生成的数据库。 VDCC还提供指导和教育以增强 CCASANET站点的临床研究和数据管理功能，促进初级研究人员和 催化该地区科学领导的持续增长。在接下来的五年中，CCASANET将评估 与该地区HIV感染和抗逆转录病毒疗法有关的临床结局和并发症，以及 确定除HIV以外的其他感染的影响，尤其是结核病，肝炎，人乳头瘤病毒， 和登革热。 CCASANET研究将研究癌症和心脏等非传染性疾病 疾病，艾滋病毒流行的区域趋势及其对脆弱人群的影响以及其他问题 公共健康在拉丁美洲的重要性。此外，研究将解决与儿童唯一相关的因素， 青少年和艾滋病毒的年轻人。我们将继续开发和应用创新的生物统计学和 信息学方法，发展我们与其他IEDEA地区的富有成效合作，并在 网站评估和数据协调计划。通过这些活动，CCASANET 3.0将有所帮助 促进艾滋病毒流行病学科学和基础国际的信息科学 研究合作。