Making connections among social ties, neural sensitivity to social signals, and outcomes

在社会关系、社会信号的神经敏感性和结果之间建立联系

• 批准号: 10490468
• 负责人: PEARL H CHIU
• 金额: $ 62.43万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10490468
• 关键词: Address; Alcohol consumption; Alcoholism; Alcohols; Anxiety; Behavioral; Brain; COVID-19; Characteristics; Computer Models; Consumption; Enrollment; Equation; Human; Individual; Life; Link; Longitudinal cohort; Measures; Mechanics; Mediating; Mediation; Mental Depression; Mental Health; Modeling; Moods; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Outcome; Participant; Persons; Play; Procedures; Process; Reporting; Request for Applications; Role; Sampling; Signal Transduction; Social Distance; Social Functioning; Social Interaction; Social isolation; Social outcome; Source; Statistical Models; Testing; Time; To specify; Trust; Visit; Work; addiction; base; behavioral economics; behavioral response; biopsychosocial; design; experience; indexing; interest; neurobiological mechanism; neuroimaging; physical conditioning; preference; recruit; relating to nervous system; response; satisfaction; social; social factors; social influence; social structure; tool

PROJECT SUMMARY Social isolation is associated with excessive alcohol use, depression, anxiety, and other poor outcomes (e.g., Daeppen et al., 2013; Moos et al., 2001; Muller et al., 2017; Zuckermann et al., 2020). Substantial variability also exists in these associations, such that individuals with limited social ties do experience positive outcomes and socially connected individuals similarly do experience negative outcomes (Bond et al., 2007; Bryan et al., 2017; Eddie & Kelly, 2017; Spohr et al., 2019). Despite the importance of social factors in alcohol use and related outcomes, the mechanisms via which social connectedness or isolation yield positive and negative outcomes remains largely unexplored, in part due to difficulties eliciting and quantifying interpersonal processes in a parametric manner. We have previously shown that sensitivity to social signals may be parameterized in the context of interactive behavioral economic games and provide powerful tools with which to examine sources of variability and potential mechanisms through which social preferences are related to mental health (Chung et al., 2015; Chiu et al., 2008; King-Casas et al., 2005, 2008; King-Casas & Chiu, 2012). Here, we use these tools to test the possibility that sensitivity to social signals in the context of social interaction influences how social ties yield variability in alcohol use, mood, and anxiety. To examine associations among social connectedness, sensitivity to social signals, and outcomes, we combine a longitudinal cohort design including time-lagged mediation analyses, functional neuroimaging, and a behavioral economic social exchange task. We will assess these associations (i) contemporaneously in Aim 1, (ii) over time in Aim 2, and (iii) following social restrictions related to COVID-19 in a large online sample in Aim 3. The broad hypothesis is that sensitivity to social signals (as measured by neurocomputational indices) will both moderate and mediate associations between social ties and alcohol use and related outcomes. The work is submitted in response to PAR-19-373 requesting applications addressing basic mechanisms of social connectedness, connection, and isolation, including those related to COVID-19. The application further is in line with specific interests of NIAAA and NIMH and in “mechanistic studies of the biopsychosocial causes and effects of social connection and isolation” and “behavioral [and] neurobiological mechanisms of social connection and isolation leading to alcohol use, addiction, or cessation of consumption.”

项目总结