Practice Core

项目概要：癌症平等的人群研究和临床试验 （实践）共享资源核心 癌症公平性人口研究和临床试验（PRACTICE）共享资源核心 将建立在现有的临床试验核心（CTC）的基础设施上，该基础设施为 Meharry/Vanderbilt-Ingram癌症中心/田纳西州立大学癌症合作伙伴关系（MVTCP）自 它的诞生虽然CTC在将临床试验带到纳什维尔的患者基地方面发挥了重要作用 Meharry医学院（MMC）的综合医院（NGH），以更全面地解决癌症健康问题 尽管存在差距，但我们有责任通过预防，早期发现， 治疗，生存和姑息治疗在纳什维尔大都会统计区（MSA），由 我们的伙伴关系。因此，我们建议建立PRACTICE共享资源核心， 使NGH患者群受益，促进制药商发起的研究，并扩大伙伴关系的覆盖范围 为纳什维尔医疗服务不足的人提供帮助MVTCP在人口科学研究方面具有很强的实力 加强现有的临床研究实力。例子包括MMC领导的研究， 田纳西州立大学（大津）和范德比尔特-英格拉姆癌症中心（VICC）的研究人员与 全州范围内的癌症登记处招募乳腺癌病因学研究，肺癌筛查试验， 检测，在服务不足的地区进行烟草控制试验，加强癌症研究的参与者招募， 与癌症外展核心和转化病理学共享合作收集生物标本 资源核心。在进行治疗性临床试验方面也有丰富的历史， VICC的临床试验办公室（CTO）和NGH的CTO。共同实践的首要使命 资源核心是提高治疗性临床试验的收益，同时扩大少数族裔和 服务不足的患者进行癌症护理连续体的研究。分享实践 Resource Core与医学博士Lucy Spalluto在她提出的项目的起源中进行了广泛的合作， 对得不到充分服务的妇女进行乳腺癌风险评估。我们将协助实施 这项研究和传播的结果。我们的核心还将支持其他临床和基于人口的科学 癌症护理连续体的研究。这可大致分为三个主题领域 重点关注减少癌症健康差距：1）预防和早期发现; 2）干预性试验， 癌症治疗期间和之后的观察性研究;以及3）实施医疗保健干预措施 to improve改善cancer癌症care护理delivery交付.实践共享资源核心将实现以下具体目标： 1)扩大与患者基础相关的治疗性临床试验和癌症控制研究组合， 梅哈里NGH和纳什维尔MSA; 2）在梅哈里NGH建立癌症队列，作为资源 3）为临床学员提供培训和导师服务 在开展临床试验以及在招募和留住研究中得不到充分服务的人群方面。

PROJECT SUMMARY: POPULATION RESEARCH AND CLINICAL TRIALS IN CANCER EQUITY (PRACTICE) SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, it is incumbent upon us to augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. Therefore, we propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University (TSU) and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is also a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Shared Resource Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum. This can be broadly categorized into three thematic domains focused on decreasing cancer health disparities: 1) prevention and early detection; 2) interventional trials and observational studies during and following cancer treatment; and 3) implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Shared Resource Core will address the following specific aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.