Practice Core

项目摘要：癌症公平中的人群研究和临床试验 (实践)共享资源核 癌症公平(实践)共享资源核心中的拟议人群研究和临床试验 将建立在现有临床试验核心(CTC)的基础设施上，该核心已为 Meharry/Vanderbilt-Ingram癌症中心/田纳西州立大学癌症伙伴关系(MVTCP)自 它的诞生。虽然CTC在将临床试验带到纳什维尔的患者基地方面发挥了重要作用 位于梅哈里医学院(MMC)的综合医院(NGH)，更全面地解决癌症健康问题 为了消除差距，我们有责任加强这些努力，开展预防、及早发现、 纳什维尔大都会统计区(MSA)的治疗、生存和姑息治疗，由 我们的伙伴关系。因此，我们建议建立实践共享资源核心，以进一步 造福NGH患者基础，促进研究人员发起的研究，并扩大合作伙伴关系的覆盖范围 纳什维尔MSA的弱势群体。MVTCP在人口科学研究方面具有强大的实力 这将增强现有的临床研究实力。例子包括由MMC领导的研究， 田纳西州立大学(TSU)和范德比尔特-英格拉姆癌症中心(VICC)的调查人员合作 全州癌症登记机构招募乳腺癌病因学研究人员，早期肺癌筛查试验 Detect，一项在服务不足的人群中进行的烟草控制试验，加强癌症研究和研究的参与者招募 与癌症推广中心合作收集生物标本，并分享翻译病理学 资源核心。在进行治疗性临床试验方面也有丰富的历史， VICC的临床试验办公室(CTO)和NGH的CTO。实践的首要使命是分享 资源核心是增加治疗性临床试验的收益，同时扩大少数族裔和 在整个癌症护理连续体系中，对服务不足的患者进行研究。分享的做法 Resources Core与Lucy Spalluto医学博士广泛合作，在她提出的项目的起源中检查 在服务不足的妇女中实施乳腺癌风险评估。我们将协助实施 这项研究和成果的传播。我们的核心还将支持其他临床和基于人群的科学 在整个癌症护理连续体中进行研究。这可以大致分为三个主题领域 侧重于减少癌症健康差距：1)预防和早期发现；2)介入试验和 癌症治疗期间和之后的观察性研究；以及3)保健干预措施的实施 以改善癌症护理服务。实践共享资源核心将解决以下具体目标： 1)扩大与患者基础相关的治疗临床试验和癌症控制研究的组合 在Meharry和纳什维尔MSA；2)在Meharry的NGH开发一个癌症队列，作为资源 为未来的癌症护理连续体研究；以及3)为临床实习生提供培训和指导 在进行临床试验以及招募和留住研究中未得到充分服务的人群方面。

PROJECT SUMMARY: POPULATION RESEARCH AND CLINICAL TRIALS IN CANCER EQUITY (PRACTICE) SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, it is incumbent upon us to augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. Therefore, we propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University (TSU) and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is also a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Shared Resource Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum. This can be broadly categorized into three thematic domains focused on decreasing cancer health disparities: 1) prevention and early detection; 2) interventional trials and observational studies during and following cancer treatment; and 3) implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Shared Resource Core will address the following specific aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.