Understanding breast cancer subtypes in Black women

了解黑人女性乳腺癌亚型

• 批准号: 9102023
• 负责人: Maureen Sanderson
• 金额: $ 7.83万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9102023
• 关键词: Address; Age; Age at Menarche; Breast; Breast Cancer Risk Factor; Breast Feeding; Cancer Etiology; Case-Control Studies; Cessation of life; Classification; Clinical; Collection; Contraceptive Usage; Development; Diagnosis; Disease; Epidermal Growth Factor Receptor; Estrogen Receptors; Etiology; Factor Analysis; Fluorescent in Situ Hybridization; Future; Gene Expression Profiling; Health; Hormone Receptor; Hormone replacement therapy; Hormones; Human; Immunohistochemistry; Incidence; Knowledge; Malignant Neoplasms; Mammary Neoplasms; Menopause; Modeling; Obesity; Oral Contraceptives; Outcome; Participant; Physical activity; Process; Progesterone Receptors; Race; Reporting; Risk; Risk Factors; South Carolina; Specimen; Staging; Tennessee; Term Birth; Tissue Sample; Tumor Markers; Tumor Subtype; Tumor Tissue; Woman; age group; base; cancer diagnosis; cancer subtypes; experience; immunohistochemical markers; malignant breast neoplasm; modifiable risk; molecular subtypes; mortality; outcome forecast; parity; population based; racial difference; screening; triple-negative invasive breast carcinoma

 DESCRIPTION (provided by applicant): Little is understood about what factors might explain why Black women tend to be diagnosed with more aggressive disease than White women. Based on characterization by immunohistochemical (IHC) markers, in every age group, White women have the highest rates of estrogen receptor (ER)+ breast cancer and Black women have the highest rates of ER- breast cancer. Moreover, triple negative breast cancer [TNBC; ER-, progesterone receptor (PR)-, human epidermal growth factor receptor 2 (HER2)-], an aggressive subset of basal-like breast cancer, is more common among Black women than among White women and has a worse prognosis than other subtypes. Recent studies, conducted largely among White women, have reported differences in risk by breast cancer subtype associated with hormone-related and other risk factors, such as age at menarche, oral contraceptive use, parity, age at first full-term birth, breastfeeding, age at menopause, hormone replacement therapy use, obesity and physical activity, suggesting that subtypes of breast tumors may have distinct etiologies. Few breast cancer studies have included large numbers of Black women, despite known marked racial differences in cancer incidence by subtype, and most studies did not collect tumor tissue to allow for detailed characterization of tumor subtypes. To address this issue, we propose to collect tumor tissue specimens from 710 Black breast cancer cases, to classify breast tumors by hormone-receptor status, and to examine associations between hormone-related and other risk factors and breast cancer subtypes among Black women. The association of breast cancer with many modifiable risk factors appears to differ by tumor subtype; therefore, it is essential to perform subtyping of all breast tumors in future studies. The utilization of a soon to be completed population-based case-control study of Black women is a highly efficient approach to the collection and classification of breast cancer tumor tissue since we have already obtained participants' permission. This proposed project will be one of the most comprehensive and well-powered studies to investigate the associations between hormone-related and other risk factors and breast cancer subtypes among Black women. Moreover, the collection of tumor tissue will provide immediate future opportunities to extend these risk factor analyses to intrinsic molecular subtypes. The results of this study will fill an important gap in current knowledge regarding assessment of hormone-related factors that increase risk for aggressive breast cancer among Black women, and will assist in delineating Black women at high (or low) risk for breast cancer subtypes with a poor prognosis who will most benefit from screening, and may provide new targets to reduce the risk of aggressive breast cancer among Black women. This may pave the way for the development of clinically useful breast cancer prediction models specific to race and breast cancer subtype.

 描述（由申请人提供）：很少有人了解什么因素可能解释为什么黑人妇女往往被诊断为更具侵略性的疾病比白色妇女。基于免疫组织化学（IHC）标记物的表征，在每个年龄组中，白色女性的雌激素受体（ER）+乳腺癌发病率最高，黑人女性的ER-乳腺癌发病率最高。此外，三阴性乳腺癌[TNBC; ER-、孕酮受体（PR）-、人表皮生长因子受体2（HER 2）-]是基底细胞样乳腺癌的一种侵袭性亚型，在黑人女性中比在白色女性中更常见，并且比其他亚型具有更差的预后。最近的研究，主要是在白色妇女中进行的，报告了乳腺癌亚型的风险差异，这些风险与月经初潮年龄、口服避孕药的使用、产次、首次足月分娩的年龄、母乳喂养、绝经年龄、激素替代疗法的使用、肥胖和体力活动有关，表明乳腺肿瘤的亚型可能有不同的病因。很少有乳腺癌研究包括大量的黑人妇女，尽管已知的显着的种族差异，癌症发病率的亚型，大多数研究没有收集肿瘤组织，以允许肿瘤亚型的详细特征。 为了解决这个问题，我们建议从710例黑人乳腺癌病例中收集肿瘤组织标本，按乳腺癌受体状态对乳腺肿瘤进行分类，并研究黑人妇女中乳腺癌相关和其他危险因素与乳腺癌亚型之间的关联。乳腺癌与许多可改变的危险因素的关联似乎因肿瘤亚型而异;因此，在未来的研究中对所有乳腺肿瘤进行亚型分型是必要的。利用一项即将完成的基于人群的黑人妇女病例对照研究是一种高效的方法来收集和分类 乳腺癌肿瘤组织，因为我们已经获得了参与者的许可。这项拟议的项目将是最全面和最有力的研究之一，以调查黑人妇女中与乳腺癌相关的风险因素和其他风险因素与乳腺癌亚型之间的关联。此外，肿瘤组织的收集将提供近期的机会，将这些风险因素分析扩展到内在分子亚型。这项研究的结果将填补一个重要的空白，在目前的知识评估与乳腺癌相关的因素，增加黑人妇女中侵袭性乳腺癌的风险，并将有助于划定黑人妇女在高（或低）风险的乳腺癌亚型与预后不良谁将最受益于筛查，并可能提供新的目标，以减少黑人妇女中侵袭性乳腺癌的风险。这可能为开发针对种族和乳腺癌亚型的临床有用的乳腺癌预测模型铺平道路。