Increasing HPV Vaccine Utilization Among African-Amerian Girls Through Social...

尽管过去几十年宫颈癌筛查有所增加，但非洲裔美国女性 宫颈癌的发病率和死亡率比白人妇女高得多。人类乳头瘤病毒(HPV)的高危型16型和18型持续感染已知导致70%的宫颈癌。自2006年以来，FDA已经批准了两种疫苗，用于预防由这些高危类型的生殖器HPV引起的宫颈癌。临床试验表明，这些疫苗在预防HPV16型和18型感染、癌前宫颈疾病以及由此导致的宫颈癌方面几乎100%有效。 根据2009年全国免疫调查，非裔美国人和白人女孩的HPV疫苗启动率相似(44%)，但非洲裔美国人和白人女孩完成所需三剂疫苗的比率较低(分别为23%和29%)。非裔美国女孩越来越多地接受和完成HPV疫苗系列将降低非裔美国女性的宫颈癌发病率，再加上持续的巴氏检测，最终可以减少宫颈癌的种族差异。作为癌症外展核心下的一个假设驱动的研究项目，我们建议开发和测试针对非裔美国女孩及其父母的适合文化的社会营销干预的可行性和影响，以提高HPV疫苗系列的利用率和完成度。拟议的项目遵循Bryant和他的同事所描述的基于社区的预防营销模式，该模式将社会营销理论和技术与基于社区的参与性研究方法相结合，以指导基于证据的战略的规划和实施，以解决公共卫生问题。

Despite increases in cervical cancer screening in the past few decades, African American women have substantially higher rates of cervical cancer incidence and mortality than white women. Persistent infection with high-risk types 16 and 18 of human papillomavirus (HPV) is known to cause 70% of cervical cancers. Since 2006 the FDA has approved two vaccines developed to prevent cervical cancer caused by these high-risk types of genital HPV. Clinical trials have demonstrated these vaccines to be nearly 100% efficacious in preventing infection of HPV types 16 and 18, precancerous cervical disease, and resulting cervical cancer. According to the 2009 National Immunization Survey, rates of initiation of the HPV vaccine were similar for African American and white girls (44%), but rates of completion of the three required doses were lower for African American versus White girls (23% and 29%, respectively). Increasing uptake and completion of the HPV vaccine series among African American girls will reduce rates of cervical cancer among African American women, which in combination with continued Pap testing, can eventually reduce racial disparities in cervical cancer. As a hypothesis-driven research project under the Cancer Outreach Core, we propose to develop and test the feasibility and impact of a culturally-appropriate social marketing intervention targeting African American girls and their parents to increase utilization and completion of the HPV vaccine series. The proposed project follows the model of Community-Based Prevention Marketing as described by Bryant and colleagues, which combines social marketing theories and techniques with community-based participatory research approaches to guide the planning and implementation of evidence-based strategies for addressing public health concerns.