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Increasing HPV Vaccine Utilization Among African-Amerian Girls Through Social...

通过社会活动提高非裔美国女孩 HPV 疫苗的使用率

基本信息

批准号：
8534735
负责人：
Maureen Sanderson
金额：
$ 4.36万
依托单位：
MEHARRY MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8534735
关键词：
Address African African American Age Attitude Belief Cancer Etiology Caregivers Cervical Cervical Cancer Screening Church Clinic Clinical Trials Communities Community based prevention Data Aggregation Data Sources Daughter Disease Dose Enrollment Family Feedback Focus Groups Genital system Human Papilloma Virus Vaccine Human Papillomavirus Human papillomavirus 16 Human papillomavirus 18 Immunization Incidence Individual Infection Infection prevention Intervention Interview Knowledge Malignant Neoplasms Malignant neoplasm of cervix uteri Marketing Modeling Modification Outreach Research Pap smear Parents Phase Pilot Projects Population Premalignant Public Health Radio Registries Research Research Project Grants Schools Series Social Marketing Surveys Techniques Television Testing Text The Vanderbilt-Ingram Cancer Center at the Vanderbilt University Time Vaccination Vaccines Woman base cancer health disparity cohort community based participatory research evidence base girls high risk mortality outreach prevent prototype social theories uptake

项目摘要

Despite increases in cervical cancer screening in the past few decades, African American women have substantially higher rates of cervical cancer incidence and mortality than white women. Persistent infection with high-risk types 16 and 18 of human papillomavirus (HPV) is known to cause 70% of cervical cancers. Since 2006 the FDA has approved two vaccines developed to prevent cervical cancer caused by these high-risk types of genital HPV. Clinical trials have demonstrated these vaccines to be nearly 100% efficacious in preventing infection of HPV types 16 and 18, precancerous cervical disease, and resulting cervical cancer. According to the 2009 National Immunization Survey, rates of initiation of the HPV vaccine were similar for African American and white girls (44%), but rates of completion of the three required doses were lower for African American versus White girls (23% and 29%, respectively). Increasing uptake and completion of the HPV vaccine series among African American girls will reduce rates of cervical cancer among African American women, which in combination with continued Pap testing, can eventually reduce racial disparities in cervical cancer. As a hypothesis-driven research project under the Cancer Outreach Core, we propose to develop and test the feasibility and impact of a culturally-appropriate social marketing intervention targeting African American girls and their parents to increase utilization and completion of the HPV vaccine series. The proposed project follows the model of Community-Based Prevention Marketing as described by Bryant and colleagues, which combines social marketing theories and techniques with community-based participatory research approaches to guide the planning and implementation of evidence-based strategies for addressing public health concerns.

尽管过去几十年宫颈癌筛查有所增加，但非裔美国女性宫颈癌的发病率和死亡率明显高于白人女性。已知 70% 的宫颈癌是由高危 16 型和 18 型人乳头瘤病毒 (HPV) 持续感染引起的。自 2006 年以来，FDA 已批准了两种疫苗，用于预防由这些高危类型的生殖器 HPV 引起的宫颈癌。临床试验表明，这些疫苗在预防 HPV 16 和 18 型感染、癌前宫颈疾病以及由此产生的宫颈癌方面几乎 100% 有效。根据 2009 年国家免疫调查，非裔美国人和白人女孩的 HPV 疫苗接种率相似 (44%)，但非裔美国人与白人女孩相比，完成三剂所需疫苗的完成率较低（分别为 23% 和 29%）。提高非裔美国女孩对 HPV 疫苗系列的接种率和完成率，将降低非裔美国女性的宫颈癌发病率，再加上持续的巴氏涂片检查，最终可以减少宫颈癌的种族差异。作为癌症外展核心下的一个假设驱动的研究项目，我们建议开发和测试针对非裔美国女孩及其父母的文化上适当的社会营销干预措施的可行性和影响，以提高 HPV 疫苗系列的利用率和完成率。拟议的项目遵循布莱恩特及其同事所描述的基于社区的预防营销模型，该模型将社会营销理论和技术与基于社区的参与性研究方法相结合，以指导规划和实施基于证据的策略来解决公共卫生问题。