Practice Core

实践核心

• 批准号: 10705109
• 负责人: Maureen Sanderson
• 金额: $ 34.62万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705109
• 关键词: Address; Area; Behavioral Sciences; Biometry; Breast; Breast Cancer Risk Factor; Cancer Center; Cancer Control; Categories; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communities; Community Developments; Conduct Clinical Trials; Continuity of Patient Care; Coupled; Data; Disease; Disparity; Early Diagnosis; Educational Materials; Eligibility Determination; Enrollment; Epidemiology; Equity; Etiology; Evaluation; Exclusion; Exclusion Criteria; Experimental Designs; Future; General Hospitals; Goals; Health; Healthcare; Incidence; Information Dissemination; Infrastructure; Institution; Intervention; Intervention Trial; Investigator-Initiated Research; Learning; Link; Logic; Longitudinal cohort; Lung; Malignant Neoplasms; Mentorship; Methods; Minority Access; Mission; Modeling; Observational Study; Oncology; Outcome; Palliative Care; Participant; Pathology; Patient Recruitments; Patient-Focused Outcomes; Patients; Population Research; Population Sciences; Prevention; Public Hospitals; Recording of previous events; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk; Risk Assessment; Risk Factors; Science; Screening for cancer; Self Management; Supportive care; Tennessee; Therapeutic Clinical Trial; Time; Training; Trust; Underserved Population; Universities; Woman; Work; anticancer research; base; behavioral health; cancer care; cancer diagnosis; cancer health disparity; cancer subtypes; cancer therapy; care delivery; clinical infrastructure; clinical training; cohort; community engaged research; community engagement; comorbidity; control trial; design; doctoral student; education research; ethnic minority; improved; inclusion criteria; lung cancer screening; malignant breast neoplasm; medical schools; metropolitan; mortality; neoplasm registry; outreach; patient population; population based; pre-doctoral; prospective; racial minority; recruit; research study; safety net; success; survivorship; tobacco control; trial design

PROJECT SUMMARY: POPULATION RESEARCH AND CLINICAL TRIALS IN CANCER EQUITY (PRACTICE) SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, it is incumbent upon us to augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. Therefore, we propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University (TSU) and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is also a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Shared Resource Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum. This can be broadly categorized into three thematic domains focused on decreasing cancer health disparities: 1) prevention and early detection; 2) interventional trials and observational studies during and following cancer treatment; and 3) implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Shared Resource Core will address the following specific aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.

项目摘要：癌症公平性的人群研究和临床试验 （实践）共享资源核心 拟议的癌症人群研究和临床试验公平性 (PRACTICE) 共享资源核心 将建立在现有临床试验核心（CTC）的基础设施之上，该基础设施为 梅哈里/范德比尔特-英格拉姆癌症中心/田纳西州立大学癌症合作伙伴关系 (MVTCP) 自 它的成立。 CTC 在将临床试验带入纳什维尔的患者群体方面发挥了重要作用 梅哈里医学院 (MMC) 综合医院 (NGH)，更全面地解决癌症健康问题 差距，我们有责任通过预防、早期发现、 纳什维尔大都会统计区 (MSA) 的治疗、生存和姑息治疗，由 我们的合作伙伴关系。因此，我们建议建立PRACTICE共享资源核心，以进一步 造福 NGH 患者群、促进研究者发起的研究并扩大合作范围 为纳什维尔 MSA 服务欠佳的人提供服务。 MVTCP在人口科学研究方面具有雄厚实力 这将增强现有的临床研究实力。例子包括 MMC 领导的研究， 田纳西州立大学 (TSU) 和范德比尔特-英格拉姆癌症中心 (VICC) 的研究人员正在与 全州癌症登记处招募乳腺癌病因研究、肺癌早期筛查试验 检测，在服务不足的地区开展烟草控制试验，加强癌症研究的参与者招募，以及 与癌症外展核心和转化病理学共享合作收集生物样本 资源核心。进行治疗性临床试验也有丰富的历史，这些试验涉及药物之间的相互作用。 VICC 的临床试验办公室 (CTO) 和 NGH 的 CTO。 PRACTICE Shared 的总体使命 资源核心是提高治疗性临床试验的收益，同时扩大少数群体和 服务不足的患者参与整个癌症护理连续体的研究。实践分享 Resource Core 与医学博士 Lucy Spalluto 广泛合作，提出了她的拟议项目，该项目检查了 对服务不足的妇女实施乳腺癌风险评估。我们将协助实施 这项研究和结果的传播。我们的核心还将支持其他临床和基于人群的科学 整个癌症护理连续体的研究。这可以大致分为三个主题领域 重点关注减少癌症健康差异：1）预防和早期发现； 2）介入试验和 癌症治疗期间和治疗后的观察性研究； 3) 实施医疗保健干预措施 改善癌症护理服务。 PRACTICE 共享资源核心将实现以下具体目标： 1）扩大与患者基础相关的治疗性临床试验和癌症控制研究的组合 梅哈里 (Meharry) 的 NGH 和纳什维尔 MSA； 2) 在 Meharry 的 NGH 建立一个癌症队列作为资源 用于整个癌症护理连续体的未来研究； 3）为临床实习生提供培训和指导 进行临床试验以及招募和保留服务不足的人群进行研究。