National Alzheimer's Coordinating Center

项目总结 NCRAD在研究方案的制定和现场培训方面发挥着关键的领导作用。NCRAD 使用标准化的方法来存储、存储和检索样本。在过去的时间里 十年来，NCRAD的DNA银行已经成为所有ADRC的标准做法。NCRAD NOW 使用统一的数据集维护29,424名接受ADRC评估的研究参与者的DNA (UDS)和另外3,823个具有先前开发的最小数据集的数据。全纵向 这些样本的临床数据存储在NACC，关键变量的数据集有限 转到了NCRAD。NCRAD现在正在扩大基于血液的样本储存的范围 来自具有良好性格的亚洲发展研究中心参与者。随着血液学的快速发展 生物标记物，迫切需要在美国建立一个中心实验室，能够 以标准化的方式处理大量样品。NACC和NCRAD将 合作收集血液样本数据，并向ADRC提供奖励付款 通过修改NACC的现有分包协议以及建立更高效的数据 存储大量数据的系统，便于NACC的数据组和管理团队访问。

PROJECT SUMMARY NCRAD plays a key leadership role in study protocol development and site training. NCRAD utilizes standardized approaches to sample banking, storage, and retrieval. Over the past decade, DNA banking at NCRAD has become a standard practice for all ADRCs. NCRAD now maintains DNA from 29,424 ADRC-evaluated research participants with a uniform dataset (UDS) and another 3,823 with the previously developed minimal dataset. Full longitudinal clinical data for these samples are housed at the NACC with a limited data set of key variables transferred to NCRAD. NCRAD is now broadening the range of blood-based samples banked from the well characterized ADRC participants. With the rapid development of blood-based biomarkers, there is an urgency to have a central laboratory in the United States that can process large numbers of samples in a standardized manner. NACC and NCRAD will collaborate on collecting the blood sample data and providing incentive payments to the ADRCs via modifying the existing subaward agreements at NACC as well as build more efficient data systems to store large data to be easily accessible by the data group and admin team at NACC.