National Alzheimer's Coordinating Center

国家阿尔茨海默病协调中心

• 批准号: 10505203
• 负责人: Walter Anthony Kukull
• 金额: $ 9.18万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505203
• 关键词: Agreement; Alzheimer' s Disease; Blood; Blood specimen; Clinical Data; DNA; Data; Data Set; Development; Incentives; Information Systems; Laboratories; Leadership; Modification; Participant; Play; Process; Research; Retrieval; Role; Sampling; Site; Standardization; Training; United States; base; blood-based biomarker; payment; protocol development

PROJECT SUMMARY NCRAD plays a key leadership role in study protocol development and site training. NCRAD utilizes standardized approaches to sample banking, storage, and retrieval. Over the past decade, DNA banking at NCRAD has become a standard practice for all ADRCs. NCRAD now maintains DNA from 29,424 ADRC-evaluated research participants with a uniform dataset (UDS) and another 3,823 with the previously developed minimal dataset. Full longitudinal clinical data for these samples are housed at the NACC with a limited data set of key variables transferred to NCRAD. NCRAD is now broadening the range of blood-based samples banked from the well characterized ADRC participants. With the rapid development of blood-based biomarkers, there is an urgency to have a central laboratory in the United States that can process large numbers of samples in a standardized manner. NACC and NCRAD will collaborate on collecting the blood sample data and providing incentive payments to the ADRCs via modifying the existing subaward agreements at NACC as well as build more efficient data systems to store large data to be easily accessible by the data group and admin team at NACC.

项目摘要 NCRAD在研究方案制定和研究中心培训中发挥关键领导作用。NCRAD 利用标准化的方法来建立样本库、存储和检索。过去 十年来，NCRAD的DNA库已成为所有ADRC的标准做法。NCRAD现在 使用统一的数据集维护来自29，424名ADRC评估的研究参与者的DNA (UDS)另外3,823个是用以前开发的最小数据集。全部纵向 这些样本的临床数据保存在NACC中，关键变量的数据集有限 转到NCRAD。NCRAD现在正在扩大血液样本库的范围 从ADRC的参与者身上。随着以血液为基础的 生物标志物，迫切需要在美国建立一个中心实验室， 以标准化的方式处理大量样品。NACC和NCRAD将 合作收集血液样本数据，并向药物滥用研究中心提供奖励 通过修改NACC现有的分包协议，以及建立更有效的数据， NACC的数据组和管理团队可以轻松访问存储大量数据的系统。