National Alzheimer's Coordinating Center

项目概要 NCRAD 在研究方案制定和现场培训方面发挥着关键的领导作用。 NCRAD 利用标准化方法进行样本银行、存储和检索。过去的事 十年来，NCRAD 的 DNA 库已成为所有 ADRC 的标准做法。现在的NCRAD 使用统一的数据集保存 29,424 名 ADRC 评估的研究参与者的 DNA (UDS) 和另外 3,823 个使用先前开发的最小数据集的数据。全纵向 这些样本的临床数据保存在 NACC 中，其中关键变量的数据集有限 转移到NCRAD。 NCRAD 现在正在扩大储存的血液样本的范围 来自特征明确的 ADRC 参与者。随着血液基业的快速发展 生物标志物，迫切需要在美国建立一个中心实验室，可以 以标准化方式处理大量样品。 NACC 和 NCRAD 将 合作收集血液样本数据并向 ADRC 提供奖励金 通过修改 NACC 现有的子奖励协议以及建立更有效的数据 存储大数据的系统，以便 NACC 的数据组和管理团队可以轻松访问。

PROJECT SUMMARY NCRAD plays a key leadership role in study protocol development and site training. NCRAD utilizes standardized approaches to sample banking, storage, and retrieval. Over the past decade, DNA banking at NCRAD has become a standard practice for all ADRCs. NCRAD now maintains DNA from 29,424 ADRC-evaluated research participants with a uniform dataset (UDS) and another 3,823 with the previously developed minimal dataset. Full longitudinal clinical data for these samples are housed at the NACC with a limited data set of key variables transferred to NCRAD. NCRAD is now broadening the range of blood-based samples banked from the well characterized ADRC participants. With the rapid development of blood-based biomarkers, there is an urgency to have a central laboratory in the United States that can process large numbers of samples in a standardized manner. NACC and NCRAD will collaborate on collecting the blood sample data and providing incentive payments to the ADRCs via modifying the existing subaward agreements at NACC as well as build more efficient data systems to store large data to be easily accessible by the data group and admin team at NACC.