NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)

国家阿尔茨海默病协调中心 (NACC)

• 批准号: 6922807
• 负责人: Walter Anthony Kukull
• 金额: $ 281.54万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6922807
• 关键词: Alzheimer' s disease; Internet; cooperative study; data collection; data management; experimental designs; health science research support; human data; information systems; longitudinal human study; method development; neuropathology

DESCRIPTION (provided by applicant): This is the Competing Continuation application of the National Alzheimer's Coordinating Center (NACC). Between about 1984 and 1997, no data were centrally collected for the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging. Establishment of an interim data center and a Minimum Data Set in about 1997 led to the NIA issuance of an RFA for an Alzheimer's Disease Data Coordinating Center. Since receiving the interim center Minimum Data Set (MDS), NACC has successfully refined and expanded the overall database, reduced missing data, increased data validity, expanded neuropathological data, added Center-wide data surveys, and increased accessibility to the data through the use of web-based data access and entry. The capabilities provided for use of combined ADC data have not been experienced by the ADCs prior to the establishment of NACC. With over 60,000 subjects, this is currently the largest Alzheimer's and related disorders database ever assembled in the U.S. NACC was additionally charged with increasing collaboration between the ADCs, not only through the use of the MDS but also through the promotion of investigator-initiated collaborative projects and the provision of statistical, methodological and database management consulting to the ADCs and for the collaborative projects. In the next grant cycle, NACC will continue to expand on these efforts. The Uniform Data Set (UDS) has now been mandated for use in all ADCs by NIA. NACC will build a database structure to implement the UDS, collect the data and integrate it seamlessly with the existing data. NACC will develop a means of capturing referral source and selection method data for all new UDS enrollees. These data will help describe and increase the external validity of analyses which use the database and will form the basis for ADCs to select the most comparable controls for their cases. NACC will continue its successful collaborative project program and will also encourage small secondary data analysis studies from junior investigators. NACC will continue design and analysis consulting, and expand its efforts to increase communication and collaboration through the NACC web site. NACC will also conduct its own data analyses and develop methodological research relevant to the needs of the ADCs and research in general. Finally, NACC will continue its administrative coordinating activities to facilitate meetings of the ADC Directors and Core Leaders.

描述（由申请人提供）：这是国家阿尔茨海默病协调中心（NACC）的竞争延续申请。大约在1984年到1997年间，由国家老龄研究所资助的29个阿尔茨海默病中心（adc）没有集中收集数据。大约在1997年建立了一个临时数据中心和一个最小数据集，导致NIA发布了一个阿尔茨海默病数据协调中心的RFA。自从获得临时中心最小数据集（MDS）以来，NACC成功地完善和扩展了整个数据库，减少了缺失数据，提高了数据有效性，扩展了神经病理数据，增加了中心范围的数据调查，并通过使用基于web的数据访问和输入增加了对数据的可访问性。在NACC成立之前，ADC还没有体验过使用综合ADC数据的能力。这是目前美国最大的阿尔茨海默病及相关疾病数据库，有超过6万名受试者