National Alzheimer's Coordinating Center

国家阿尔茨海默病协调中心

• 批准号: 10430699
• 负责人: Walter Anthony Kukull
• 金额: $ 78.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10430699
• 关键词: Address; Administrative Supplement; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; COVID-19; COVID-19 pandemic; COVID-19 patient; Caring; Clinical; Clinical Research; Collaborations; Communities; Computer Analysis; Computers; Consent; Data; Data Analyses; Data Collection; Data Element; Data Set; Data Storage and Retrieval; Dementia; Electronic Health Record; Eligibility Determination; Enrollment; Environment; Funding; Future; Genetic; Genetic Variation; Genomics; Health system; Healthcare; Human Genetics; Indiana; Infrastructure; Language; Leadership; Long COVID; National Institute on Aging; Neurologic; Outcome; Participant; Patient Care; Patient Recruitments; Patients; Phenotype; Population; Process; Recording of previous events; Research; Research Design; Research Personnel; SARS-CoV-2 negative; SARS-CoV-2 positive; Site; Standardization; Testing; Time; United States Centers for Medicare and Medicaid Services; Universities; Vaccination; Washington; Work; base; clinical care; clinical research site; cloud based; data integration; data sharing; electronic structure; exome; expectation; genetic analysis; genetic information; improved; innovation; instrument; interest; patient population; phenotypic data; prospective; recruit

PROJECT SUMMARY The Covid-19 pandemic has had a substantial impact on vulnerable aging populations across the world. Clinical care of patients with Alzheimer’s associated dementia are especially vulnerable to the effects of Covid- 19 and Covid-19 has been associated with poor outcomes in patients. In this National Alzheimer’s Coordinating Center (NACC) Administrative Supplement proposal, we are providing the infrastructure for investigating the genetic factors associated with poor outcomes in patients with AD and a history of Covid-19. We are leveraging and deploying new data collection instruments for Covid-19 phenotypes to the Alzheimer’s Disease Research Centers Consortium (ADRCs). This work will provide a high impact, innovative, and economical demonstration of the use of routine clinical care data to quantitatively and accurately phenotype patients. Care data in the form of Centers for Medicare and Medicaid Services (CMS) administrative claims and electronic health record (EHR) will be the basis for this demonstration. NACC will collaborate with NIAGADS and three pilot sites, Washington University St. Louis, Columbia University and Indiana University ADRCs. This work will be done in three aims. First, we will support additional clinical research at the pilot clinical sites and will deploy new prospective data collection instruments to support post acute sequelae of Covid-19. Second, we will assess feasibility of and begin to collect EHR and CMS data in partnership with the ADRC pilot sites and the NIA. Finally, we will collaborate with NIAGADS to enable collaborative analysis of integrated phenotype and genetic data of enrolled participant data. Together this proposal, if funded, will place important infrastructure for the study of AD associated phenotypes and Covid-19.

项目摘要 2019冠状病毒病大流行对全球脆弱的老龄化人口产生了重大影响。 阿尔茨海默病相关痴呆患者的临床护理特别容易受到新冠肺炎的影响， 19和Covid-19与患者的不良结局相关。在这个国家老年痴呆症 协调中心（NACC）行政补充提案，我们正在提供基础设施， 调查与AD患者和Covid-19病史的不良结局相关的遗传因素。 我们正在利用和部署新的数据收集工具，用于新冠病毒表型和阿尔茨海默氏症 疾病研究中心联盟（ADRC）。这项工作将提供一个高影响力，创新， 使用常规临床护理数据进行定量和准确表型的经济论证 患者医疗保险和医疗补助服务中心（CMS）行政索赔形式的护理数据 电子健康记录（EHR）将是此次演示的基础。NACC将与 NIAGADS和三个试点地点，华盛顿大学圣路易斯分校、哥伦比亚大学和印第安纳州大学 ADRC。这项工作将在三个目标。首先，我们将在试点阶段支持更多的临床研究 临床研究中心，并将部署新的前瞻性数据收集工具，以支持 新冠肺炎第二，我们将评估电子健康记录和内容管理系统数据的可行性，并开始与 ADRC试点地点和NIA。最后，我们将与NIAGADS合作， 登记参与者数据的综合表型和遗传数据。这项提案如果获得资助，将使 研究AD相关表型和Covid-19的重要基础设施。