National Alzheimer's Coordinating Center

项目摘要/摘要 NACC(如U01 AG016976，在华盛顿大学)自1999年以来一直活跃。现有的NAccess 基础设施在本申请的设施和资源部分进行了描述。的宏伟目标 过去的供资周期与目前U24 RFA的周期是一致的--即：a.)这个 中央枢纽，用于组织和实现ADRC计划内外的交流， 包括年会和指导委员会；b)国家数据资源，从 阿尔茨海默病研究中心(ADRC)及其附属数据和样本库；以及 C.)当前和未来AD/ADRD研究的促进者。 NACC在实现这些目标方面拥有相当多的经验和成功，并为继续 在一个快速发展的领域取得成功。新的数据和方法正在生物标志物等领域出现， 神经病理学，以及早期发现的测试。通过战略性地采用技术进步， 我们将在这些成就的基础上加快发展。在我们已经很重要的基础上 在能力方面，我们将：促进和扩大ADRC计划内外的交流； 按照公平原则扩大NACC的信息学能力；进行和支持 方法和应用研究，利用生物统计学和数据科学方面的深厚专业知识；以及 通过为以下几个项目提供同行评审的竞争性资金来支持职业生涯早期的研究科学家 每年的“初级调查员”。我们的目标是通过以下方式继续改进我们在每个领域的方法 将久经考验的方法与我们正在开发的新工具和创新相结合，以满足 NIA ADRC计划和领域不断变化的科学、技术和通信需求。

Project summary/abstract NACC (as U01 AG016976, at University of Washington) has been active since 1999. The existing NACC infrastructure is described in the Facilities and Resources Section of this application. The broad goals of the past funding cycles are consistent with those of the current U24 RFA — that is, to serve as: a.) the central hub for organizing and enabling communication within and outside of the ADRC program, including annual meetings and steering committees; b.) a national data resource, collecting data from the Alzheimer's Disease Research Centers (ADRCs) as well as affiliated data and sample repositories; and c.) a facilitator of current and future AD/ADRD research. NACC has considerable experience and success in reaching these goals, and is positioned for continued success in a rapidly advancing field. New data and methods are appearing in areas such as biomarkers, neuropathology, and tests for early detection. Through the strategic adoption of technological advances, we will build on these accomplishments at an accelerated pace. Building on our already significant capabilities, we will: promote and broaden communication within and outside of the ADRC program; expand informatics capabilities of NACC consistent with FAIR principles; conduct and support methodologic and applied research, leveraging deep expertise in biostatistics and data science; and support early-career research scientists by providing peer-reviewed competitive funding for several “junior investigators” each year. We aim to continue to improve our approach in each arena by combining time-tested approaches with the new tools and innovations we are developing to meet the changing scientific, technological, and communication needs of the NIA ADRC program and the field.