NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)

描述(由申请人提供)：这是国家阿尔茨海默氏症协调中心(NACC)的竞争性延续申请。在大约1984至1997年间，没有集中收集由国家老龄研究所资助的29个阿尔茨海默病中心(ADC)的数据。大约在1997年建立了一个临时数据中心和一个最低数据集，导致NIA发布了阿尔茨海默病数据协调中心的RFA。自收到临时中心最低数据集(MDS)以来，NACC成功地改进和扩展了整个数据库，减少了缺失数据，提高了数据有效性，扩展了神经病理数据，增加了中心范围的数据调查，并通过使用基于网络的数据访问和输入提高了数据的可及性。在NACC成立之前，ADC还没有体验到使用组合ADC数据的能力。这是美国有史以来最大的阿尔茨海默氏症及相关疾病数据库，拥有超过6万名受试者。 国家反腐败委员会还负责加强发展中心之间的合作，不仅通过使用计量吸入器，而且通过促进由调查员发起的合作项目，并向发展中心和合作项目提供统计、方法和数据库管理咨询。在下一个赠款周期中，NACC将继续扩大这些努力。NIA现已授权在所有ADC中使用统一数据集(UDS)。NACC将建立一个数据库结构来实施UDS，收集数据并将其与现有数据无缝集成。NACC将为所有新的UDS参与者开发一种获取转介来源和选择方法数据的方法。这些数据将有助于描述和提高使用该数据库的分析的外部有效性，并将构成ADC为其病例选择最具可比性的对照的基础。NACC将继续其成功的合作项目计划，并将鼓励初级调查人员进行小型二级数据分析研究。NACC将继续提供设计和分析咨询，并扩大努力，通过NACC网站加强沟通和合作。NACC还将进行自己的数据分析，并开发与ADC需求和一般研究相关的方法研究。最后，NACC将继续其行政协调活动，以促进ADC董事和核心领导人的会议。

DESCRIPTION (provided by applicant): This is the Competing Continuation application of the National Alzheimer's Coordinating Center (NACC). Between about 1984 and 1997, no data were centrally collected for the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging. Establishment of an interim data center and a Minimum Data Set in about 1997 led to the NIA issuance of an RFA for an Alzheimer's Disease Data Coordinating Center. Since receiving the interim center Minimum Data Set (MDS), NACC has successfully refined and expanded the overall database, reduced missing data, increased data validity, expanded neuropathological data, added Center-wide data surveys, and increased accessibility to the data through the use of web-based data access and entry. The capabilities provided for use of combined ADC data have not been experienced by the ADCs prior to the establishment of NACC. With over 60,000 subjects, this is currently the largest Alzheimer's and related disorders database ever assembled in the U.S. NACC was additionally charged with increasing collaboration between the ADCs, not only through the use of the MDS but also through the promotion of investigator-initiated collaborative projects and the provision of statistical, methodological and database management consulting to the ADCs and for the collaborative projects. In the next grant cycle, NACC will continue to expand on these efforts. The Uniform Data Set (UDS) has now been mandated for use in all ADCs by NIA. NACC will build a database structure to implement the UDS, collect the data and integrate it seamlessly with the existing data. NACC will develop a means of capturing referral source and selection method data for all new UDS enrollees. These data will help describe and increase the external validity of analyses which use the database and will form the basis for ADCs to select the most comparable controls for their cases. NACC will continue its successful collaborative project program and will also encourage small secondary data analysis studies from junior investigators. NACC will continue design and analysis consulting, and expand its efforts to increase communication and collaboration through the NACC web site. NACC will also conduct its own data analyses and develop methodological research relevant to the needs of the ADCs and research in general. Finally, NACC will continue its administrative coordinating activities to facilitate meetings of the ADC Directors and Core Leaders.