National Alzheimer's Coordinating Center

国家阿尔茨海默病协调中心

• 批准号: 10204491
• 负责人: Walter Anthony Kukull
• 金额: $ 701.85万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10204491
• 关键词: Achievement; Adoption; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Applied Research; Area; Award; Big Data; Biological Markers; Biometry; Collaborations; Communication; Complex; Consultations; Contracts; Data; Data Collection; Data Coordinating Center; Data Science; Data Set; Data Storage and Retrieval; Databases; Dementia; Early Diagnosis; Enrollment; Environment; Faculty; Funding; Future; Genetic; Genetic Diseases; Genomics; Goals; Heterogeneity; Individual; Informatics; Infrastructure; Institutes; Lead; Leadership; Link; Medicine; Methodology; Methods; Mission; Modernization; Peer Review; Positioning Attribute; Publications; Recording of previous events; Research; Research Peer Review; Research Personnel; Research Support; Resources; Risk Factors; Sampling; Scientist; Secure; Services; Site; Source; Specimen; Standardization; Techniques; Technology; Testing; Time; Translational Research; Universities; Washington; base; career; clinical database; clinical examination; cohort; community center; data access; data resource; data sharing; data visualization; deep learning; digital; disease heterogeneity; e-science; experience; high standard; imaging biomarker; improved; innovation; instrument; interest; interoperability; meetings; neuroimaging; neuropathology; novel; programs; repository; social media; success; tool; translational health science; trend; web site

Project summary/abstract NACC (as U01 AG016976, at University of Washington) has been active since 1999. The existing NACC infrastructure is described in the Facilities and Resources Section of this application. The broad goals of the past funding cycles are consistent with those of the current U24 RFA — that is, to serve as: a.) the central hub for organizing and enabling communication within and outside of the ADRC program, including annual meetings and steering committees; b.) a national data resource, collecting data from the Alzheimer's Disease Research Centers (ADRCs) as well as affiliated data and sample repositories; and c.) a facilitator of current and future AD/ADRD research. NACC has considerable experience and success in reaching these goals, and is positioned for continued success in a rapidly advancing field. New data and methods are appearing in areas such as biomarkers, neuropathology, and tests for early detection. Through the strategic adoption of technological advances, we will build on these accomplishments at an accelerated pace. Building on our already significant capabilities, we will: promote and broaden communication within and outside of the ADRC program; expand informatics capabilities of NACC consistent with FAIR principles; conduct and support methodologic and applied research, leveraging deep expertise in biostatistics and data science; and support early-career research scientists by providing peer-reviewed competitive funding for several “junior investigators” each year. We aim to continue to improve our approach in each arena by combining time-tested approaches with the new tools and innovations we are developing to meet the changing scientific, technological, and communication needs of the NIA ADRC program and the field.

项目概要/摘要 NACC（作为U 01 AG 016976，在华盛顿大学）自1999年以来一直活跃。现有的NACC 基础设施在本申请的设施和资源部分中描述。的广泛目标 过去的供资周期与当前的U24 RFA的供资周期一致，即：a.的 用于组织和实现ADRC计划内外通信的中心枢纽， 包括年度会议和指导委员会; B.）国家数据资源，收集来自 阿尔茨海默病研究中心（ADRC）以及附属数据和样本库;以及 c.）当前和未来AD/ADRD研究的促进者。 NACC在实现这些目标方面拥有相当丰富的经验和成功经验， 在快速发展的领域取得成功。新的数据和方法出现在生物标志物等领域， 神经病理学和早期检测测试。通过战略性地采用技术进步， 我们将加快步伐，在这些成就的基础上再接再厉。在我们已经很重要的基础上 能力，我们将：促进和扩大沟通内部和外部的ADRC计划; 根据FAIR原则扩大NACC的信息能力;开展和支持 方法和应用研究，利用生物统计学和数据科学的深厚专业知识; 支持早期职业研究科学家提供同行评审的竞争性资金， 每年都有“初级调查员”我们的目标是继续改进我们在每个竞技场的方法， 将经过时间考验的方法与我们正在开发的新工具和创新相结合， 不断变化的科学，技术和通信需求的NIA ADRC计划和外地。