National Alzheimer's Coordinating Center (NACC)

描述（由申请人提供）：本申请是国家阿尔茨海默病协调中心（NACC） [U01 AG016976]的竞争性延续，该中心于1999年根据国家老龄化研究所（NIA）发布的RFA首次获得资助，随后于2004年续期。本次申请的期限为2009年7月1日至2014年6月30日。与最初的RFA以及NIA和阿尔茨海默病中心（ADC）项目在之前的资助周期中积累和发展的意图一致，NACC的使命是开发和维护一个通用/标准化数据库，计算所有ADC的注册情况，并促进ADC之间的合作研究，直接基于数据库，也通过ADC研究人员的独立倡议。为此，NACC为研究者发起的合作项目和初级研究者直接基于数据库的二级数据分析项目提供竞争性的、同行评议的资助。NACC与adc密切合作，提供数据管理、统计和研究咨询，并开展自己的方法和实证科学调查。除了这些方面，NACC还承担着各种行政责任，负责adc之间以及NIA之间的互动和沟通。具体而言：维持和进一步发展国家行政协调会数据库，并促进其用于研究；继续和发展现有的统一数据集（UDS）数据质量保证和质量控制程序；通过研究资助和技术支持，促进非洲发展中国家之间的合作研究；开发与阿尔茨海默病及相关疾病研究相关的新方法和工具；对NACC数据库中的特定内容领域进行描述性和分析性研究；执行NACC的NIA要求的行政职能：为董事和核心领导会议提供后勤支持，与NIA倡议小组沟通；分配资金支持NACC数据收集工作和合作项目；并促进adc之间的通信。

DESCRIPTION (provided by applicant): This application is for the competing continuation of the National Alzheimer Coordinating Center (NACC) [U01 AG016976] first funded in 1999 in response to an RFA issued by the National Institute on Aging (NIA) and subsequently renewed in 2004. The present application is for the period of July 1, 2009 through June 30, 2014. Consistent with the original RFA and the accrued, developed intent of the NIA and the Alzheimer Disease Centers (ADC) program during the previous funding cycles, the mission of the NACC is to develop and maintain a common/standardized database, accounting for the enrollment at all ADCs, and to facilitate collaborative research among the ADC's, based directly on the database as well as through independent initiatives of ADC investigators. To that end, NACC provides for competitive, peer reviewed funding of investigator initiated collaborative projects and for junior-investigator secondary data analysis projects based directly on the database. NACC works closely with ADCs providing data management, statistical and research consulting and conducts its own methodological and empirical scientific investigations In addition to these aspects NACC also has a variety of administrative responsibilities for interactions and communications across ADCs and with NIA. Specifically: To maintain and further develop the NACC database and facilitate its use for research; To continue and build upon the Uniform Data Set (UDS) data quality assurance and quality control procedures already in place; To promote collaborative research among the ADCs through research funding and technical support; To develop new methodological tools and approaches relevant to research on AD and related disorders; To conduct descriptive and analytic studies of specific content areas from the NACC database; To perform NACC's NIA-required administrative functions: provide logistical support for directors' and core leaders' meetings, interface with NIA initiative groups; distribute funds in support of NACC data collection effort and collaborative projects; and facilitate inter-ADC communication.