National Alzheimer's Coordinating Center
国家阿尔茨海默病协调中心
基本信息
- 批准号:10749285
- 负责人:
- 金额:$ 380.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdministrative SupplementAdvisory CommitteesAlaska NativeAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmerican IndiansAreaAwardBiological MarkersClinicalCollaborationsCommunicationCountryDataData CollectionData Coordinating CenterData ScienceData SetDetectionDevelopmentDigital biomarkerDiseaseEnsureFAIR principlesFundingFutureGeneticHispanic PopulationsImageInfrastructureInterviewInvestmentsKnowledgeLeadershipMagnetic Resonance ImagingMinority GroupsMissionModalityModernizationNatureParentsParticipantPathway interactionsPatientsPilot ProjectsPoliciesPositioning AttributePositron-Emission TomographyProviderResearchResearch ActivityResearch PersonnelResourcesRoleSiteStandardizationSurveysTechnologyTherapeuticUnderserved PopulationUnited States National Institutes of HealthVisualizationWorkcloud basedcognitive testingdata infrastructuredata integrationdata managementdata repositorydata resourcedata sharingdata streamsdigitaldiverse dataelectronic dataempowermentimprovedinnovationmembermultimodal datamultimodalityneuropathologyoutreachprocess improvementprogramsrecruitrepository
项目摘要
PROJECT SUMMARY
Over the past 23 years, the National Alzheimer’s Coordinating Center (NACC) has collaborated with 42
Alzheimer’s Disease Research Centers (ADRCs) across the country to build one of the largest (46,000+
participants), oldest, and most powerful standardized and longitudinal Alzheimer’s datasets in the world. Since
our most recent competitive renewal, NACC, working in close coordination with NIA and other ADRC Program
stakeholders, has identified significant gaps in areas that are critical for delivering on the full scope of NACC’s
U24 parent award. These gaps must be urgently addressed to meet the evolving needs of the ADRC Program
and the Alzheimer’s Disease and Related Dementia (ADRD) field and to fulfill NACC's mission. NACC will meet
these challenges and amplify the impact of NACC and the ADRCs on ADRD research through this administrative
supplement by accelerating the modernization of NACC infrastructure and by expanding NACC’s role as the
data, collaboration, and communication hub for the ADRC Program. The proposed new research objectives
within this administrative supplement involve significant unanticipated expenses. They are staff-intensive and
require investments in new platforms. We have developed a comprehensive strategy for restructuring our team
and for building the required technical and programmatic infrastructure to respond to these needs. NACC will
build a modern streamlined cloud-based NACC Data Platform and Data Front Door for integrating and sharing
existing and innovative standardized multimodal data from across the ADRC Program and other ADRD data
coordinating centers. We will also improve processes for how participant data flows through NACC. We will
collaborate closely with other ADRD Coordinating Centers and initiatives to improve and create new
opportunities for integration and dissemination of standard MRI/PET images, genetic, and biomarker data. We
will also collaborate with ADRC member sites to pilot multisite digital neuropathology and digital cognitive test
data collection and integration. Additionally, we will improve our reach through a reimagined communication and
collaboration strategy with new pathways to disseminate impact as well as improve our facilitation of ADRC
consortium governance and collaboration with additional support for ADRC groups and initiatives. Finally, we
are improving ADRC data diversity by creating onramps for ADRCs to recruit and retain more participants from
historically minoritized populations highly impacted by ADRD. Together, this work amplifies NACC’s impact and
scope of work as the data, collaboration, and coordination hub for the ADRC Program with the aim of significantly
improving ADRC research impact.
项目摘要
在过去的23年里,国家阿尔茨海默氏症协调中心(NACC)与42个
阿尔茨海默病研究中心(ADRC)在全国建立一个最大的(46,000+)
参与者),世界上最古老,最强大的标准化和纵向阿尔茨海默病数据集。以来
我们最近的竞争更新,NACC,与NIA和其他ADRC计划密切合作
利益攸关方,已经确定了在对实现NACC的全部范围至关重要的领域中的重大差距
U24家长奖这些差距必须立即解决,以满足ADRC计划不断变化的需求
和阿尔茨海默病和相关痴呆症(ADRD)领域,并履行NACC的使命。NACC将与
这些挑战,并扩大NACC和ADRC对ADRD研究的影响,通过这一行政
通过加快NACC基础设施的现代化和扩大NACC作为
ADRC计划的数据、协作和通信中心。提出的新研究目标
在这一行政补充涉及重大的意外开支。它们是工作人员密集型的,
需要对新平台进行投资。我们已经制定了一个全面的战略来重组我们的团队
以及建立所需的技术和方案基础设施,以满足这些需求。NACC将
建立一个现代化的基于云的精简NACC数据平台和数据前门,用于集成和共享
现有的和创新的标准化多模态数据来自整个ADRC计划和其他ADRD数据
协调中心。我们还将改进参与者数据如何通过NACC流动的流程。我们将
与其他ADRD协调中心和倡议密切合作,以改善和创造新的
整合和传播标准MRI/PET图像、遗传学和生物标志物数据的机会。我们
还将与ADRC成员单位合作试点多地点数字神经病理学和数字认知测试
数据收集和整合。此外,我们将通过重新构想的沟通来提高我们的影响力,
与新途径的合作战略,以传播影响,并改善我们对ADRC的促进
联合体治理和协作,并为ADRC团体和倡议提供额外支持。最后我们
正在通过为ADRC创建入口来提高ADRC的数据多样性,以招募和留住更多来自
在历史上,少数群体受到严重的ADRD影响。总之,这项工作扩大了NACC的影响,
作为ADRC计划的数据、协作和协调中心的工作范围,
提高ADRC研究的影响力。
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Neuropsychological Decline Stratifies Dementia Risk in Cognitively Unimpaired and Impaired Older Adults.
- DOI:10.3389/fnagi.2022.838459
- 发表时间:2022
- 期刊:
- 影响因子:4.8
- 作者:
- 通讯作者:
Traumatic Brain Injury Characteristics Are Not Related to Neurocognitive Decline in Older Adults: A Nationwide Longitudinal Cohort Study.
创伤性脑损伤特征与老年人神经认知能力下降无关:一项全国纵向队列研究。
- DOI:10.1093/arclin/acae003
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Schaffert,Jeff;LoBue,Christian;Chiang,Hsueh-Sheng;Peters,MatthewE;HartJr,John;Cullum,CMunro
- 通讯作者:Cullum,CMunro
Noniterative adjustment to regression estimators with population‐based auxiliary information for semiparametric models
使用半参数模型的基于总体的辅助信息对回归估计进行非迭代调整
- DOI:10.1111/biom.13585
- 发表时间:2021
- 期刊:
- 影响因子:1.9
- 作者:Gao, Fei;Chan, K. C. G.
- 通讯作者:Chan, K. C. G.
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Walter Anthony Kukull其他文献
Walter Anthony Kukull的其他文献
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{{ truncateString('Walter Anthony Kukull', 18)}}的其他基金
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)
国家阿尔茨海默病协调中心 (NACC)
- 批准号:
6820247 - 财政年份:1999
- 资助金额:
$ 380.33万 - 项目类别:
National Alzheimer's Coordinating Center (NACC)
国家阿尔茨海默病协调中心 (NACC)
- 批准号:
8097315 - 财政年份:1999
- 资助金额:
$ 380.33万 - 项目类别:
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