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Research Project for NSRRC Renewal Year 21-25

NSRRC 续期研究项目 21-25

基本信息

批准号：
10553793
负责人：
RANDALL S PRATHER
金额：
$ 15.04万
依托单位：
UNIVERSITY OF MISSOURI-COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10553793
关键词：
Anatomy Applied Research Arteriosclerosis Biological Assay Biomedical Research Cardiovascular Diseases Characteristics Client Communicable Diseases Communities Country Cryopreservation Development Diabetes Mellitus Disease Domestic Pig Embryo Embryo Transfer Ensure Equipment and supply inventories Family suidae Funding Future Genetic Engineering Genetic Materials Germ Cells Goals Health Human Knock-out Medical Device Medical Research Methods Modeling Modification Molecular Monitor Optics Organ Performance Pharmaceutical Preparations Physiological Physiology Production Reagent Research Research Personnel Research Project Grants Resources Scientist Study models Technology Tissues United States Work Xenograft procedure embryo cryopreservation experience human disease improved innovation method development novel therapeutic intervention operation pig genome porcine model pre-clinical prevent repository reproductive sex somatic cell nuclear transfer sperm cell tool web-accessible

项目摘要

Abstract (Applied Research) The overall goal of this application is to continue and expand operation of the National Swine Resource and Research Center (NSRRC). During the past funding period, the NSRRC developed a non-invasive method of cryopreservation of embryos via ultra-fast cooling, improved methods for the development of somatic cell nuclear transfer embryos, developed a universal sex determining assay, and incorporated a GHR knockout in an attempt to reduce the size of domestic pigs while retaining their superior reproductive performance, and developed state-of-the-art disease monitoring and surveillance assays. The Specific Aim of the Research Core is to perform innovative research that will benefit the NSRRC and the biomedical research community. Applied research projects are aimed at improving a) the cryopreservation of pig reproductive cells, and b) the development of improved methods for the production of genetically-engineered pigs.

应用研究（Applied Research）本申请的总体目标是继续和扩大国家猪资源的运作，研究中心（NSRRC）。在过去的资助期间，NSRRC开发了一种非侵入性方法，通过超快速冷却冷冻保存胚胎，改进体细胞发育方法核移植胚胎，开发了一种通用的性别决定测定法，并将GHR敲除为了减小家猪的尺寸同时保持其上级繁殖性能，并开发了最先进的疾病监测和监测分析。的具体目标研究核心是进行创新研究，这将有利于NSRRC和生物医学研究社区应用研究项目旨在提高a）猪生殖器官的冷冻保存细胞，和B）开发用于生产基因工程猪的改进方法。