Swine Somatic Cell Genome Editing (SCGE) Center

猪体细胞基因组编辑（SCGE）中心

• 批准号: 9769993
• 负责人: RANDALL S PRATHER
• 金额: $ 112.96万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769993
• 关键词: Animal Model; Animals; Collaborations; Communities; Effectiveness; Ensure; Evaluation; Family suidae; Genes; Goals; Individual; Inflammation; Infrastructure; Methods; Modeling; Procedures; Process; Production; Public Health; Reagent; Reporter; Reporting; Research; Resources; Role; Safety; Standardization; System; Technology; Testing; Therapeutic; Translations; United States National Institutes of Health; Validation; bench to bedside; clinical application; cohort; comparative; experience; genome editing; human disease; immunogenicity; in vivo; member; new technology; novel; novel therapeutic intervention; preservation; programs; safety testing; somatic cell gene editing; tool

Project Summary – Overall The role of the Genome Editing Testing Section will be to validate unique reporter models created by the Animal Model Production Section and to test novel delivery methods and reagents provided by other members of the Somatic Cell Genome Editing (SCGE) Consortium. Additionally, the Genome Editing Testing Section will be responsible for creating detailed standard operating procedures (SOPs) and comprehensive reports for testing new genome editing technologies. It is essential to have a well- established pipeline for the validation and testing of new genome editing technology to facilitate proper refinement of the tools while ensuring the safety of the technology. The Genome Editing Testing Section will streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of new genome editing tools and delivery systems. Our group is ideally suited to provide this testing due to our unique composition of individuals that are experienced with pig production, swine biomedical models, operate successful labs that routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine Resource and Research Center (NSRRC). The Genome Editing Testing Section will have a significant impact on the overall MU Swine Testing Center for Genome Editing Technologies’ ability to accurately assess new technologies and further facilitate the ability to use genome editing in therapeutic circumstances.

项目概要-总体 基因组编辑测试部分的作用将是验证由基因组编辑测试部分创建的独特报告模型。 动物模型生产部门，并测试其他部门提供的新型给药方法和试剂 体细胞基因组编辑联盟（Somatic Cell Genome Editing，SCGE）此外，基因组编辑 测试部门将负责制定详细的标准操作规程（SOP）， 测试新基因组编辑技术的全面报告。必须有一个好的- 建立了验证和测试新基因组编辑技术的管道，以促进适当的 在确保技术安全性的同时完善工具。基因组编辑测试部分将 简化测试过程，同时保持全面和严格的比较分析， 新的基因组编辑工具和递送系统。我们的团队非常适合提供这种测试，因为我们 具有养猪经验的个体的独特组成，猪生物医学模型， 运营成功的实验室，定期测试尖端的基因组编辑技术，并与 国家猪资源与研究中心（NSRRC）。基因组编辑测试 部分将对整个MU基因组编辑猪检测中心产生重大影响 技术准确评估新技术的能力，并进一步促进利用基因组的能力 在治疗环境中进行编辑。