Swine Somatic Cell Genome Editing (SCGE) Center

项目摘要/摘要 基因组编辑测试科的作用是验证由 动物模型生产科并测试由其他机构提供的新的递送方法和试剂 体细胞基因组编辑(SCGE)联盟的成员。此外，基因组编辑 测试科负责制定标准操作程序(SOP)和全面的 测试新的基因组编辑技术的报告。这项建议的目的是测试 “第二轮”试剂，已在小鼠身上得到证实，并针对猪进行评估。在……里面 为将传递和编辑技术转换到临床做准备，我们的目标是完成安全和 猪模型的疗效研究。此外，我们将负责保存来自以下地点的样品 这些研究是对未来需求的预期。

Project Summary/Abstract The role of the Genome Editing Testing Section is to validate unique reporter models created by the Animal Model Production Section and to test novel delivery methods and reagents provided by other members of the Somatic Cell Genome Editing (SCGE) Consortium. Additionally, the Genome Editing Testing Section is responsible for creating standard operating procedures (SOPs) and comprehensive reports for testing new genome editing technologies. The purpose of this proposal is to test the "second-round" of reagents that have been proven in the mouse and targeted for evaluation in pigs. In preparation for translating delivery and editing technologies to the clinic, we aim to complete safety and efficacy studies in a swine model. Further we will be responsible for preservation of samples from these studies in anticipation of future needs.