Swine Somatic Cell Genome Editing (SCGE) Center
Swine Somatic Cell Genome Editing (SCGE) Center
批准号:
10655827
负责人:
RANDALL S PRATHER
金额:
$6.61万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-06-01 至 2024-05-31
关键词:
Animal ModelClinicCollaborationsDataData CollectionData Coordinating CenterEnsureEvaluationFamily suidaeFreezingFutureGenomeHistologicHumanIndividualLaboratoriesMethodsModelingMusPhysiologicalPreparationProceduresProductionReagentReporterReportingRoleSafetySamplingSampling StudiesTechnologyTechnology TransferTestingTissuesTranslatingTranslationsWorkanimal datadata integritydata sharingefficacy studygenome editingmembermethod developmentnovelporcine modelpreservationreagent testingsafety studysomatic cell gene editing
中文摘要
项目摘要/摘要
基因组编辑测试科的作用是验证由
动物模型生产科并测试由其他机构提供的新的递送方法和试剂
体细胞基因组编辑(SCGE)联盟的成员。此外,基因组编辑
测试科负责制定标准操作程序(SOP)和全面的
测试新的基因组编辑技术的报告。这项建议的目的是测试
“第二轮”试剂,已在小鼠身上得到证实,并针对猪进行评估。在……里面
为将传递和编辑技术转换到临床做准备,我们的目标是完成安全和
猪模型的疗效研究。此外,我们将负责保存来自以下地点的样品
这些研究是对未来需求的预期。
英文摘要
Project Summary/Abstract
The role of the Genome Editing Testing Section is to validate unique reporter models created by the
Animal Model Production Section and to test novel delivery methods and reagents provided by other
members of the Somatic Cell Genome Editing (SCGE) Consortium. Additionally, the Genome Editing
Testing Section is responsible for creating standard operating procedures (SOPs) and comprehensive
reports for testing new genome editing technologies. The purpose of this proposal is to test the
"second-round" of reagents that have been proven in the mouse and targeted for evaluation in pigs. In
preparation for translating delivery and editing technologies to the clinic, we aim to complete safety and
efficacy studies in a swine model. Further we will be responsible for preservation of samples from
these studies in anticipation of future needs.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Expanding capacity of the National Swine Resource and Research Center
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批准号:10596390
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项目类别:
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资助金额:$15.85万
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批准号:10650352
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资助金额:$112.96万
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批准号:10414785
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资助金额:$229.51万
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财政年份:2019
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负责人:RANDALL S PRATHER
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High Throughput Cryopreservation of In Vivo-Derived Swine Embryos
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批准号:7876885
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资助金额:$18.96万
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财政年份:2009
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负责人:RANDALL S PRATHER
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依托单位:
Research Project for NSRRC Renewal Year 21-25
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批准号:10553793
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资助金额:$15.04万
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财政年份:2003
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负责人:RANDALL S PRATHER
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依托单位:
Resource Core for National Swine Resource and Research Center (NSRRC) Years 21-25
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批准号:10553792
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资助金额:$135.34万
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财政年份:2003
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负责人:RANDALL S PRATHER
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批准号:8306992
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批准号:10453315
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项目类别:
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资助金额:$29.15万
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财政年份:2003
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负责人:RANDALL S PRATHER
-
依托单位:
National Swine Resource and Research Center 1
-
批准号:10286993
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项目类别:
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资助金额:$30.99万
-
财政年份:2003
-
负责人:RANDALL S PRATHER
-
依托单位:
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-
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-
负责人:RANDALL S PRATHER
-
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项目类别:
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资助金额:$135.79万
-
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-
负责人:RANDALL S PRATHER
-
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批准号:9095926
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项目类别:
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资助金额:$142.94万
-
财政年份:2003
-
负责人:RANDALL S PRATHER
-
依托单位:
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项目类别:
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-
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-
负责人:RANDALL S PRATHER
-
依托单位:
National Swine Resource and Research Center 1
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批准号:10223670
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项目类别:
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资助金额:$49.99万
-
财政年份:2003
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负责人:RANDALL S PRATHER
-
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-
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负责人:RANDALL S PRATHER
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依托单位:
海外基金