Swine Somatic Cell Genome Editing (SCGE) Center

项目概要/摘要 基因组编辑测试部分的作用是验证由基因组编辑测试部分创建的独特报告模型。 动物模型生产部门，并测试其他部门提供的新型给药方法和试剂 体细胞基因组编辑联盟（Somatic Cell Genome Editing，SCGE）此外，基因组编辑 测试科负责制定标准操作规程（SOP）和全面的 用于测试新的基因组编辑技术的报告。本提案的目的是测试 已在小鼠中得到验证并针对猪进行评估的“第二轮”试剂。在 准备翻译交付和编辑技术的诊所，我们的目标是完成安全和 在猪模型中的功效研究。此外，我们将负责保存样品， 这些研究是为了满足未来的需求。

Project Summary/Abstract The role of the Genome Editing Testing Section is to validate unique reporter models created by the Animal Model Production Section and to test novel delivery methods and reagents provided by other members of the Somatic Cell Genome Editing (SCGE) Consortium. Additionally, the Genome Editing Testing Section is responsible for creating standard operating procedures (SOPs) and comprehensive reports for testing new genome editing technologies. The purpose of this proposal is to test the "second-round" of reagents that have been proven in the mouse and targeted for evaluation in pigs. In preparation for translating delivery and editing technologies to the clinic, we aim to complete safety and efficacy studies in a swine model. Further we will be responsible for preservation of samples from these studies in anticipation of future needs.