Swine Somatic Cell Genome Editing (SCGE) Center

猪体细胞基因组编辑（SCGE）中心

• 批准号: 10650352
• 负责人: RANDALL S PRATHER
• 金额: $ 201.91万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10650352
• 关键词: Acceleration; Animal Model; Animals; Collaborations; Communities; Effectiveness; Ensure; Evaluation; Family suidae; Genes; Goals; Individual; Inflammation; Infrastructure; Methods; Modeling; Procedures; Process; Production; Public Health; Reagent; Reporter; Reporting; Research; Resources; Role; Safety; Standardization; System; Teaching Method; Technology; Testing; Therapeutic; Translations; United States National Institutes of Health; Validation; bench to bedside; clinical application; cohort; comparative; experience; genome editing; human disease; immunogenicity; in vivo; member; new technology; novel; novel therapeutic intervention; porcine model; preservation; programs; safety testing; somatic cell gene editing; tool

Project Summary – Overall The role of the Genome Editing Testing Section will be to validate unique reporter models created by the Animal Model Production Section and to test novel delivery methods and reagents provided by other members of the Somatic Cell Genome Editing (SCGE) Consortium. Additionally, the Genome Editing Testing Section will be responsible for creating detailed standard operating procedures (SOPs) and comprehensive reports for testing new genome editing technologies. It is essential to have a well- established pipeline for the validation and testing of new genome editing technology to facilitate proper refinement of the tools while ensuring the safety of the technology. The Genome Editing Testing Section will streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of new genome editing tools and delivery systems. Our group is ideally suited to provide this testing due to our unique composition of individuals that are experienced with pig production, swine biomedical models, operate successful labs that routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine Resource and Research Center (NSRRC). The Genome Editing Testing Section will have a significant impact on the overall MU Swine Testing Center for Genome Editing Technologies’ ability to accurately assess new technologies and further facilitate the ability to use genome editing in therapeutic circumstances.

项目摘要--总体 基因组编辑测试科的作用将是验证由 动物模型生产科并测试由其他机构提供的新的递送方法和试剂 体细胞基因组编辑(SCGE)联盟的成员。此外，基因组编辑 测试科将负责制定详细的标准操作程序(SOP)和 测试新的基因组编辑技术的综合报告。拥有一口井是必不可少的- 为验证和测试新的基因组编辑技术建立了渠道，以促进适当的 在保证技术安全的同时，对工具进行改进。基因组编辑测试科将 简化测试流程，同时保持全面和严格的比较分析 新的基因组编辑工具和传递系统。我们的团队非常适合提供这项测试，因为我们 在生猪生产、生猪生物医学模型、 运营成功的实验室，定期测试尖端基因组编辑技术，并与 世界知名的国家生猪资源研究中心(NSRRC)。基因组编辑测试 部分将对整个MU猪基因组编辑测试中心产生重大影响 技术准确评估新技术并进一步促进使用基因组的能力 在治疗性环境中进行编辑。