Resource Core for National Swine Resource and Research Center (NSRRC) Years 21-25

摘要(资源) NSRRC成立于2003年，正在满足猪医学研究界的需求。这个 NSRRC为猪研究社区提供中央存储库服务，方法是导入、存储和 分布生猪生物资源。它不仅保证了有价值的模型被保存下来，而且 免费提供，它允许研究人员满足NIH对资源共享的要求，缓解 分配负担由个人研究人员承担，并提供遗传和健康质量控制。这个 在过去的三年半里，NSRRC通过以下方式为NIH猪群服务：创造了25头 新模型；进口12个新模型；将猪重新派生到高健康的NSRRC大楼；冷冻保存 配子、胚胎和雄性和雌性体细胞样本；将细胞、组织、器官或猪分布到73头 43个不同机构的调查人员；为本科生、毕业生提供培训机会 学生、驻院兽医和访问科学家；以及赞助工作坊，促进使用 研究中的猪。在资助期间，NSRRC将继续：进口现有的猪模型 人类健康和疾病；重新衍生猪以消除病原体，并进行健康监测以确保 保持特定的无病原体状态；超低温保存和储存配子、胚胎和雄性 和雌性体细胞，以防止未来失去有价值的模型；分发专业知识、试剂、细胞， 组织、器官和无特定病原体的猪；使用最先进的技术创造新的遗传 医学研究界所需的工程猪；并作为培训和 与利用猪模型进行研究有关的教育活动。

Abstract (Resource) Established in 2003, the NSRRC is meeting the needs of the swine medical research community. The NSRRC provides a central repository service to the swine research community by importing, storing, and distributing swine biological resources. Not only does it assure that valuable models are preserved and are freely available, it allows researchers to satisfy NIH requirements for resource sharing, relieves the distribution burden from individual investigators, and provides genetic and health quality control. The NSRRC has served the NIH swine community over the past 3 ½ years by doing the following: creating 25 new models; importing 12 new models; rederiving pigs into the high health NSRRC building; cryopreserving gamete, embryo, and male and female somatic cell samples; distributing cells, tissues, organs or pigs to 73 investigators at 43 different institutions; providing training opportunities to undergraduates, graduate students, resident veterinarians, and visiting scientists; and sponsoring workshops that promote the use of pigs in research. During the funding period, the NSRRC will continue to: import existing swine models of human health and disease; rederive pigs to eliminate pathogens and health monitoring to assure maintenance of a specific pathogen-free status; cryopreserve and store gametes, embryos, and both male and female somatic cells to prevent future loss of valuable models; distribute expertise, reagents, cells, tissues, organs, and specific pathogen-free pigs; use state of the art techniques to create new genetically engineered pigs needed by the medical research community; and serve as a site for training and educational activities related to research employing swine models.