Resource Core for National Swine Resource and Research Center (NSRRC) Years 21-25

国家养猪资源和研究中心 (NSRRC) 21-25 年的资源核心

• 批准号: 10553792
• 负责人: RANDALL S PRATHER
• 金额: $ 135.34万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553792
• 关键词: Anatomy; Area; Arteriosclerosis; Biological; Cardiovascular Diseases; Cells; Characteristics; Client; Communicable Diseases; Communities; Country; Cryopreservation; Dedications; Derivation procedure; Development; Diabetes Mellitus; Discipline; Disease; Educational Activities; Educational workshop; Embryo; Ensure; Equipment and supply inventories; Europe; Family suidae; Female; Funding; Future; Genes; Genetic; Genetic Engineering; Genetic Materials; Germ Cells; Health; Human; Individual; Infrastructure; Institution; Laboratories; Maintenance; Medical Research; Methods; Modeling; Modification; Monitor; Optics; Organ; Physiological; Physiology; Plasmids; Quality Control; Reagent; Research; Research Personnel; Resource Sharing; Resources; Sampling; Scientist; Seminal fluid; Services; Site; Somatic Cell; Study models; Techniques; Technology; Tissues; Training and Education; United States; United States National Institutes of Health; Veterinarians; Visit; Work; Xenograft procedure; animal care; biosecurity; experience; germ free condition; graduate student; human disease; human model; improved; male; meetings; operation; pathogen; pig genome; porcine model; preservation; prevent; recruit; repository; sperm cell; training opportunity; undergraduate student; web-accessible

Abstract (Resource) Established in 2003, the NSRRC is meeting the needs of the swine medical research community. The NSRRC provides a central repository service to the swine research community by importing, storing, and distributing swine biological resources. Not only does it assure that valuable models are preserved and are freely available, it allows researchers to satisfy NIH requirements for resource sharing, relieves the distribution burden from individual investigators, and provides genetic and health quality control. The NSRRC has served the NIH swine community over the past 3 ½ years by doing the following: creating 25 new models; importing 12 new models; rederiving pigs into the high health NSRRC building; cryopreserving gamete, embryo, and male and female somatic cell samples; distributing cells, tissues, organs or pigs to 73 investigators at 43 different institutions; providing training opportunities to undergraduates, graduate students, resident veterinarians, and visiting scientists; and sponsoring workshops that promote the use of pigs in research. During the funding period, the NSRRC will continue to: import existing swine models of human health and disease; rederive pigs to eliminate pathogens and health monitoring to assure maintenance of a specific pathogen-free status; cryopreserve and store gametes, embryos, and both male and female somatic cells to prevent future loss of valuable models; distribute expertise, reagents, cells, tissues, organs, and specific pathogen-free pigs; use state of the art techniques to create new genetically engineered pigs needed by the medical research community; and serve as a site for training and educational activities related to research employing swine models.

摘要（资源） NSRRC成立于2003年，旨在满足猪医学研究界的需求。的 NSRRC通过导入、存储和管理，为猪研究社区提供中央存储库服务。 分布猪生物资源。它不仅确保有价值的模型得到保存， 免费提供，它允许研究人员满足NIH的资源共享要求，减轻了 分配负担，从个人研究者，并提供遗传和健康质量控制。的 在过去的3年半里，NSRRC通过以下方式为NIH养猪社区服务： 新模型;引进12个新模型;转育猪进入高健康国家标准化研究中心大楼;冷冻保存 配子、胚胎和雄性和雌性体细胞样品;将细胞、组织、器官或猪分配到73个 在43个不同的机构进行调查;向本科生、研究生和 学生，驻地兽医和访问科学家;并赞助讲习班，促进使用 猪在研究在资助期间，NSRRC将继续： 人类健康和疾病;再衍生猪，以消除病原体和健康监测，以确保 保持特定的无病原体状态;冷冻保存和储存配子，胚胎和雄性 和女性体细胞，以防止未来失去有价值的模型;分发专业知识，试剂，细胞， 组织、器官和无特定病原体的猪;使用最先进的技术来创造新的基因 医学研究界所需的工程猪;并作为培训和 与使用猪模型的研究有关的教育活动。