Expanding capacity of the National Swine Resource and Research Center

扩大国家生猪资源研究中心的能力

• 批准号: 10596390
• 负责人: RANDALL S PRATHER
• 金额: $ 796.96万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596390
• 关键词: Anatomy; Animal Housing; Animals; Area; Arteriosclerosis; Biomedical Research; Breeding; Budgets; Cardiovascular Diseases; Characteristics; Communicable Diseases; Communities; Development; Diabetes Mellitus; Disease; Electricity; Family suidae; Foundations; Funding; Genetic; Housing; Human; Infrastructure; Institutes; Modeling; Modification; Molecular; Optics; Organ; Physiological; Physiology; Reagent; Research; Research Personnel; Research Project Grants; Resources; Study models; System; Training Activity; United States National Institutes of Health; Water; Xenograft procedure; germ free condition; human disease; interest; novel therapeutic intervention; pig genome; porcine model; prevent; square foot; tool

Project Summary The National Swine Resource and Research Center (NSRRC) has been the only NIH-funded swine resource center to develop and supply swine models for biomedical research. Swine share anatomic and physiologic characteristics with humans that make them the optimal model for the study of many human diseases, e.g., cardiovascular disease, optic diseases, arteriosclerosis, diabetes, and specific infectious diseases. The anatomy and physiology of pig organs also makes them likely candidates for xenotransplantation donors. Thus, increasingly, pigs are being used as models for human disease. With a sequenced pig genome, major advances have been made in developing swine-specific reagents and creating swine models carrying targeted genetic modifications. With these tools in place, pig models are making unprecedented contributions toward unraveling the molecular basis of human disease and developing new therapeutic strategies. With the interest in swine models, the NSRRC is responsible for supplying swine models for research projects sponsored by over ten different NIH institutes. Since its foundation in 2006, activity of NSRRC has continued to increase. Housing capacity of NSRRC, on the other hand, had few improvements throughout the years and no expansion has been made to the Specific Pathogen Free (SPF) swine facility. The limitation is now preventing development of additional models or suppling animals to a diverse group of researchers. The center can’t meet the demand to properly serve as the national resource of swine models. To resolve this limitation and excel as the main swine resource center in the U.S., we propose to increase the housing capacity of NSRRC. We propose to construct a building consisting of 8,420 gross square feet (GSF) of swine housing area connected to the existing NSRRC SPF swine facility to enhance swine housing capacity of NSRRC. Original construction of the NSRRC anticipated expansion of the center and infrastructure (water, electricity, and sewer) sufficient for this proposed expansion was installed. Utilizing the existing infrastructure will allow us to acquire more swine housing space within the budget. In addition, the proposed animal housing area will enable us to maximize the use of penning in the existing facility as the enhanced space will allow us to place all swine models under a suitable penning system. The NSRRC has been at the forefront of providing swine models to the biomedical community. Our activities have been significantly expanded since inception and swine housing is now a critical limitation for us to serve the biomedical community. The space restriction hinders us from rapidly breeding and establishing swine models to accommodate demands from the NIH community. The proposed construction is not limited to just additional animal housing but will permit more efficient use of the existing space, permitting the NSRRC to explore application of new swine models in various research fields and extend our training activity on the use of swine models.

项目摘要 国家生猪资源与研究中心(NSRRC)是美国国立卫生研究院资助的唯一生猪资源 为生物医学研究开发和提供猪模型的中心。猪的解剖和生理特征 人类的特征使它们成为研究许多人类疾病的最佳模型，例如， 心血管疾病、眼科疾病、动脉硬化、糖尿病和特定的传染病。这个 猪器官的解剖和生理学也使它们成为异种移植捐赠者的候选对象。 因此，猪越来越多地被用作人类疾病的模型。有了一个测序的猪基因组，梅杰 在开发猪特异性试剂和建立携带靶向基因的猪模型方面取得了进展 基因改造。有了这些工具，猪模型正在做出前所未有的贡献 揭开人类疾病的分子基础，开发新的治疗策略。带着利息 在猪模型方面，NSRRC负责为由 十多个不同的国立卫生研究院。自2006年成立以来，NSRRC的活动持续增加。 另一方面，NSRRC的住房能力多年来几乎没有改善，也没有 已对无特定病原体(SPF)猪设施进行了扩展。这一限制现在阻止了 开发更多的模型或向不同的研究人员提供动物。中心不能见面 做好猪模国家级资源的需求。要解决这一限制，并作为 作为美国主要的生猪资源中心，我们建议增加NSRRC的住房容量。我们 提议建造一座由8,420平方英尺(GSF)的猪舍面积组成的建筑 对现有的NSRRC SPF养猪设施进行改造，以提高NSRRC的养猪能力。原创建筑 NSRRC预计中心和基础设施(水、电和下水道)有足够的扩建 为这一拟议的扩建安装了设备。利用现有的基础设施将使我们能够获得更多 猪住房面积在预算之内。此外，拟议的动物收容所将使我们能够 最大限度地利用现有设施的围栏，因为增强的空间将允许我们放置所有的猪 在适当的围栏系统下的模型。NSRRC一直走在向 生物医学界。自成立以来，我们的业务已显著扩大，并建立了猪舍 现在是我们为生物医学社区服务的一个关键限制。空间的限制妨碍了我们 快速繁殖和建立猪模型，以适应NIH社区的需求。这个 拟议的建设不仅限于增加动物收容所，还将允许更有效地利用 现有空间，允许NSRRC探索新的猪模型在各种研究领域的应用 并扩大我们关于使用猪模型的培训活动。